ID W5KJS8_ASTMX Unreviewed; 653 AA.
AC W5KJS8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Zinc finger FYVE domain-containing protein 1-like {ECO:0000313|Ensembl:ENSAMXP00000007840.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000007840.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000007840.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KJS8; -.
DR STRING; 7994.ENSAMXP00000007840; -.
DR Ensembl; ENSAMXT00000007840.2; ENSAMXP00000007840.2; ENSAMXG00000007619.2.
DR eggNOG; KOG1818; Eukaryota.
DR GeneTree; ENSGT00940000165302; -.
DR HOGENOM; CLU_020922_0_0_1; -.
DR InParanoid; W5KJS8; -.
DR OrthoDB; 277036at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000007619; Expressed in intestine and 14 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15734; FYVE_ZFYV1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR042427; ZFYV1.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46624; AGAP002036-PA; 1.
DR PANTHER; PTHR46624:SF2; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1-RELATED; 1.
DR Pfam; PF01363; FYVE; 2.
DR SMART; SM00064; FYVE; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50178; ZF_FYVE; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 476..537
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 591..651
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 653 AA; 72268 MW; 4086CC9B8BEE2C3B CRC64;
MSEMLLKEME EVSLGPPSKK EEKEREGRSF LLVDGSEALQ VKDEAHFLQK LGCNGSQGVK
VLSIFGNTGD GKSHTLNHVL FDGEEVFATS PSPNSCTIGV WAAYDQRLGL VVLDTEGLLG
ASTQQNQRMR MLLKVLAVSD IAVYRTRAER LHNDLFQFLG SASAAYLKHF TPQLRALSNR
CGLDVPISNL GPAVVVFQET SRTQLLGHDS SGPADVLLQK RFHDLGQGTE AFSSVQYVGT
QTITPPTDYS QLLEVIRQQV KNTASRAPRQ PAIVYSALQA LSERFCGEIS DDKISMYSFF
PDEYFTCPSV CLSCSVRCKN GMNHQKDRVP HMADGLCQYA HQYNNKVLIC KRCYEGGREV
IVIPKTSAST DNQWLGLAKY AWSGYVLECP NCGIIYRSRQ YWMGNQDPES SVVRPEVKHV
WMGSETFQTD HQNAAQRVLD GVNYVIQSMA EYSVGPTKAV TSWITDQVAP PYWRPNAEIT
ECHGCKRVFE EAERKHHCRS CGEGFCQACS TRSMPVPEKG WGSSPVRVCD ACHREGGAAQ
SSQVAQTEPR ALVARRVTEV AQSTLDLVSN AVDYPLCFVK GVARPEYWVP DHEITTCHQC
SRDFTSTVPK HHCRACGQGV CGGCSTQNRP VPARGWDHPV RVCDGCAASL DTQ
//
