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Database: UniProt
Entry: W5KMX7_ASTMX
LinkDB: W5KMX7_ASTMX
Original site: W5KMX7_ASTMX 
ID   W5KMX7_ASTMX            Unreviewed;      4824 AA.
AC   W5KMX7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   22-NOV-2017, entry version 29.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSAMXP00000008939};
GN   Name=RYR3 (1 of many) {ECO:0000313|Ensembl:ENSAMXP00000008939};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000008939, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000008939, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000008939};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000008939}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMXP00000008939}.
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DR   EMBL; APWO01111660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01111661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01111662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01111663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01111664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01111665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01111666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01111667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01111668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01111669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAMXT00000008939; ENSAMXP00000008939; ENSAMXG00000008666.
DR   GeneTree; ENSGT00760000119152; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 2.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 3.
DR   SMART; SM00449; SPRY; 2.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 3.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4156   4175       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4385   4405       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4447   4466       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4590   4615       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4638   4660       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4680   4697       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4703   4724       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      151    196       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      204    258       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      264    322       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      985   1182       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1228   1445       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3905   3931       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     3501   3526       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4824 AA;  548102 MW;  3BAE933F6B2A4E2E CRC64;
     QDDEVVLQCV ACIQKENRKF CLSAEGLGNR LCYLEPTSEA KNMVIYVPSD QNICIYVLKM
     IKKLKRLQEL RFSPGGESVG AAVSGGVATV SVVVAMLLLH CFSSIHTGCS EPERLNKTDK
     LDLDRVTRQV QTKSEACWWT IHPASKQRSE GEKVRIGDDL ILVSVSSERY LHLSISNGNI
     QVDASFMQTL WNVHPTCSGS NVEEGYLLGG HVMRLFHGHD EVLTIPGSDQ SEEEQRIVNY
     ETGKVGAKAR SLWRLEPLRI SWCGSHIRWG QPFRLRHLTT GHYLALTDDR GLVLQDREKS
     DTNSTAFCFR ASKKKKTQSK SASSRDCKKD GCCVAVSIHS GRAGAEGFLG PDLSSSNPGP
     DSKNPPCPGR HGAFPDQLVF HKQQEKEDFR GRTAVLMFID LDSLAGKKRV AVLLPIEEVL
     QTLNDLITYF QLPDAELEHE EKQIKLRSLK NRQNLFKQEG MLTLVSNCID RLSVYNSAAH
     FGECAGEEAG AAWKDILNLL YELLGNFLKI NMSSCVSKFI HEEHWIIRHI DDFWENASGI
     LEVLHCILIE SPEALNIIQR GHIKSIISLL YKHGRNHKIL DVLCSLCVCN GVAVRANQNL
     ICDHLLPKRD LLLQTRLVND VQSNVANNTL GILILSMSFF KRWPPEMKSF PTVLKEGRSS
     QRFCAPAHPK PQIWIGFRSG DCGGHRVGSL FFYGHYFGSG GNSWWRVDVH IEFCRDLISC
     ELALLPFRVF QHYMQSKHAS FHLSRAFVVF LGKNSYQRLF FLALQFHLIY PFYPKFQFHP
     LLKSQDLYSI QPLMLVKSPN ILCRPLISPF CIESHCHRSY TVSYTTVHTV IQMKHLGKKI
     RDHLKTGVKQ HKVIQKHNSP SCYSFLIRDD NKRQHPCLVD FSKLPETEKN YNLQMSTETL
     KTLLALGCHV VQFNVNAEED LKKVKLPKNY MMSNGYKPTP LDLSEVKLTP GQELLVDKLS
     ENAHNVWAKD RIKQGWTYGI QQDLKSKRNP RLVPYALLDE RTKKSNRDSL REAIRTLIGY
     GYNIEPPDQE GVSGLVVERL SIDKIRFFRL ERTYAVKTGK WYFEFEAVTG GDMRVGWARP
     GVRPDVELGT DDQAYVFDGY KGHRLHQGSR LFGRCWHAGD VVGCMINMED KSMIFTLNGE
     ILITNKGSEL CFADFETDDG FIPVCSLGLS QVGRMNLGKD ASTFKYYTMC GLQEGFEPFA
     VNMNREVTTW FSKRLPTFVN VPRDHGHIAV TRIDGTIDSP PCLKATHKTF GTQNSNADMV
     FFRLSMPVEF HSTFKCNPTI DMNGVHEEEP LKLKHRFIIY IYSNYYHSVR VFAGQDPSCV
     WVGWVTPDYH YYSSSFNLSK IRTVTVTLGD ERGRVHESYC VKRSNCYMVW GGDISTATHS
     SRRSNVDLEI GCLIDLSTGM VTFTVNGKEL ATSYQVEPNT KLFPAVFVRP TSPNLFQFEL
     AKIKNTMPLS SAIFKSEHKN PVPQCPPRLD VQTIKAVLWS RMPNTFLKVE TARVSERHGW
     QVQCIEPLQM LAVHIPEENR CVDIMELSEQ EDLCTFHYHT LKLYCALCAL GNTRVAHALC
     SHLDQSQLLY TIDNQYLSGM LREGFYNVLI CIHLETAKAA RLMMNNEFII PVTPETCSIK
     LFPDASKHHQ PPGVGLSTSL KPKLSFAPPC FISTKRDQHL YSPEIPLDVL REKAISMLTE
     AVQGGGHHIR DPVGGSVEYQ FVPILRLIST LLTMGVFASQ DVHMILLLIE PNVFGEQRED
     GVGEATEKEG VTGAEEKAVE AGEEEAKDNK QPIKGLLEKR LPESVKRQMC ELLHYFCDCE
     LRHRIEAIVS FSDTFVAKLQ YNQKFRYNEL MLALNMSAAV TAKKTKEFRS PPQEQINMLL
     NFSMGEDCPC PEDIQEELYD FHNELSLHCG IPMAEEEEEQ DMSIKGRLLA LVYKIKGQPH
     RAEEKPTEKE EATPSNLKEL ISQTMVSWAQ ETHIQDPELV RVMFSLLRRQ YDSIGELLRA
     MRKSYSISAA SVHDTIHLLA SLGQIRSLLS VRMGKEEEQL MIDGLGDIMN NKVFYQHPNL
     MRVLGMHETV MEVMVNVLGG GKSQEIAFPK MVASCCRFLC YFCRISRQNQ KAMFDHLSYL
     LENSSVGLAS PSMRGSTPLD VAASSVMDNN GLALALEEPD LDKVVTYLAS CGLQSCPMLL
     SKGYPDIGWN PIEGERYLSF LRFAVFVNGE SVEENSSVVV KLLIRRPECF GPALRGEGGN
     GLLAAMKEAI KISETPALDL PCTAQGLTSD TSTEDDEEEE VVHMGNAIMS FYSALIDLLG
     RCAPEMHLIN KGKGEALRIR AILRSLVPTE DLVGIISIPL KMPVANKDGS VTEPDMSACF
     CPDHKAPMVL FLDRVYGIED QSFLLHLLEV GFLPDLRAAA SMDTDALRTT ETALAMNRYI
     GSAMLPLLTR CAPHFSGTEH HAALIDSTLH TIYRLSKGSS LTKAQRDAIE ECLLAVCKYL
     RPSMLQQLLR RLVFDVPLLS EYCKMPLKLL TNHYEQNWKY YCLPSGWGSY GMASEEELLL
     TKKIFWGIFD SLSQKKYEQE LFKMAMPCLS AIAGALPPDY VDSSLSTTLE KPVSVDAQGN
     FDPRPISTSN ISLPEKLEYI ANKYSEHSHD KWSAEKVGLL HSTNITTGPR LLATLAVYTG
     FAMGCWWPND EVPAVVLAVV PAVHKVIQKQ CVRLVEENMM PRSISHFLQI NALNETIFVW
     NLGEMLSVVY RIKQQFKHKP INSKISKGGG THPLLVPYDT LTAKEKARDR EKAQELFRFL
     QINGYAITRG LKDMEQDSSS MEKRFAYKFL KKLLKYVDSA QEFIAHLVYY SEAMASSGKN
     DRSPHEQEIK FFAKVLLPLI DQYFKNHSLY FLSSPSKNLS SSGYASNKEK EMVTSLFCKL
     AALVRHRISL FGSDSATMVS CLHILAHTLD TRTVMKSGSE LVKAGLRTFF ENAAEDLEKT
     LENLKLGKFT HSRSQMKGVS QNINYTTVAL LPILTALFEH ITEHQFGVDL LLDDVQVSCY
     RILTSLYSLG TGKNIYVERQ LPALGECLAT LAGAMPVAFL EPHLNSHNPC SVFNTKTARE
     RAILGMPDSV EEMCPEVPRL DCLMKDINDM SESGARYTEM PHVIEVVLPM LCNYLSYWWE
     RGPENQPKSS ATVCSTTVTS EHLSVILGNI LKILNSNLGI DEASWMKRIA VYAQPIISKA
     RADLLKTHFL PTLEKLKKKT VKVVAEEELL KADGKGDTQE AELLILDEFA VLCRDLYAFY
     PMLIRYVDNN RSRWLKEPDP DSNELFRMVA EIFILWCKSH NFKREEQNFV VQNEINNLSF
     LTGDSKTKMA KSGIKEQAGG QDQERKHKKR RGEFYSIQTS LIVAALKKML PIGLNMCTPG
     DQELISLAKT RYSLKDTDEE VKEHLRQNMH LQEKTEDPAV RWQLNLYKDV VVRNEGPPDP
     ERTVDRLQTI SAAVFHLEQV EQPLRSKKCV WQKLLSKQRK RAVVACFRMA PLYNLPRHRS
     INLFLTGYQR IWIETETYSF EEKLVQDLAR TQRKAEEEEE EVAEEQPDPL HQLILHFSHN
     ALTERSSLEE DPLYIAYADM MAKSCAEDEE DEDEEGKEKT FEEKEMEKQK TLYQQARLHD
     RGAAEMALQM ISASKGRLGP MVTYTLKLGI SVLNGGNIIV QQKMLDYLKE KRDAGFFKSL
     SGLMQSCSVL DLNAFERQNK AEGLGMVTEE GSINVRERGS KVLQNDEFTK DLFRFLQLLC
     EGHNNDFQNF LRTQTGNTTT VNIIISTVDY LLRLQESISD FYWYYSGKDI MDEAGQRNFS
     KALAVAKQIF NSLTEYIQGP CIGNQQSLAH SRLWDAVVGF LHVFANMQMK LSQDSSQIEL
     LKELMDLQKD MIVMLLSLLE GNVVNGTIGK QMVDTLVESS SNVEMILKFF DMFLKLKDLT
     TSDSFKEHDS DSKGVISKRE FQKSMESQKQ YSQSEIEFLL SCAEADENDM FNYVEFVKRF
     HEPAKDIGFN VAVLLTNLSE HMPHDSRLAT FLSLAESVLS YFEPYLGRIE IMGGAKRIER
     VYFEISESSR TQWEKPQVKE SKRQFIFDVV NEGGESEKME LFVNFCEDTI FEMQLASLIS
     EPDAVERTEE DNEDSQSVAE EPEEEEEERT LESFSAFTMA CFSVKKNLCS LRKLLTFRSV
     KKHYKKFRKM SVREMIRGFF SFFWMIFVGV FRFLYNLVWG FFHILWTTLF GGGLVEGAKN
     MKVTDILGNM PDPTQFGIHG DVLEAEKLEA SEACLVAEMD QMVEGDQVEM DLMSELMSFQ
     QKKEGGKHGA EPGLGDVSEV VGVDSPSLAA AVRQKKAQEA ASKKADESEF KTESEKTDSE
     DGEKKDPDKG KEGSLVESSS NEGKKPLKRR LGQKKEEPEA FMGSFFAGLD IYQTKMLNYL
     ARNFYNLRFL ALFVAFAINF ILLFYKVTGE DSEEVDPWTG RGEEEDGGVE YFVLQESTGY
     MAPTLRFLAV LHTLISFLCV VGYYYLKVPL VVFKREKEIA RKLEFDGLYI TEQPSDDDIK
     GQWDRLVINT PSFPNNYWDK FVKRKVINKY GDLYGAERIA ELLGLDKSAL DFNPTEEAIA
     KEASLVSWLS SIDTKYHIWK MGVVFTDNSF LYLVWYTTMS ILGHYNNFFF AAHLLDIAMG
     FKTLRTILSS VTHNGKQLVL TVGLLAVVVY LYTVVAFNFF RKFYNKSADE DEPDMKCDDM
     MTCAYLTILY LSTKVLYLYL LQYYFYLTIL YLYICIFVST GLIIDAFGEL RDQQEQVKED
     METKCFICGI GNDYFDTTPH GFETHTLQEH NLANYLFFLM YLINKDETEH TGQESYVWKM
     YQERCWDFFP AGDCFRKQYE DQLG
//
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