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Database: UniProt
Entry: W5KMZ7_ASTMX
LinkDB: W5KMZ7_ASTMX
Original site: W5KMZ7_ASTMX 
ID   W5KMZ7_ASTMX            Unreviewed;      4972 AA.
AC   W5KMZ7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   25-OCT-2017, entry version 25.
DE   SubName: Full=Ryanodine receptor 1a (skeletal) {ECO:0000313|Ensembl:ENSAMXP00000008959};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000008959, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000008959, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000008959};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000008959}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMXP00000008959}.
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DR   EMBL; APWO01116302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01116303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01116304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01116305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01116306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01116307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01116308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01116309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01116310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01116311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAMXT00000008959; ENSAMXP00000008959; ENSAMXG00000008578.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; DIPARRN; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4302   4325       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4532   4552       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4616   4637       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4763   4794       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4853   4876       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      106    161       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      168    213       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      221    276       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      282    340       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      587    797       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1013   1209       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1343   1557       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1886   1920       {ECO:0000256|SAM:Coils}.
FT   COILED     3645   3672       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4972 AA;  563917 MW;  D00A1B753EA6411E CRC64;
     MAEGGEGEEE IQFLRTEDQV VLQCTATILK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICCFILE QSLSVRALQE MLSHTSEARP GQAVDLDKWS SQGGGHRTLL YGHAILLRHT
     HSSMYLSCLT TSRSLTDKLA FDVGLQEDST GEACWWTIHP ASKQRSEGEK VRVGDDLILV
     SVSSERYLHL SYASGDLMVD ASFMQTLWNM NPVCSGCELA EGYLTGGYVL RLFHGHMDEC
     LAIPAADQGA DQRRNAHYEG GAVCSHARSL WRLEPLRIGW SGSHIKWGQA FRIRHITTGR
     YLSLDDEKGL LLVDPEKANT KSSAFCFRAS KVRLSEIERV CTSGMTEHIC LWLKSSEPIP
     HSTLRYLTLS HSFSLCLQLS YIMGAQSAVS KARFCCCMQV IQFEFAVIHN VISAFLGQFS
     GDNLLCLYNI RRIRPFLSQD ATQVLVQSLV ISRLDYKKII DCKVLKCKLL HIAYFAFDSK
     GMITLVLDCI DRLNVYNTAA HFSEFAGEEA AESWKEIVNL LYELLASLIR GNRANCALFC
     DNLDWLVSKL DRLEASSGIL EVLYCILIES PEVLNIIQEN HIKSIIALLD KHGRNHKVLD
     VLCSLCVCNG VAVRSNQNLI TENLLPGRDL LLQTSIINYV TSMRPNIFLG TCEGSTQYKK
     WYYELIVDHV ESFLTPQAGH LRVGWALTEG YSPYPGGGEG WGSNGVGDDL YSYSFDGLHL
     WSGRVPRQVA SPSQHTLAAE DVVSCCLDLS VPSISFRVNG HPVQGMFENF NLDGLFFPVV
     SFSAGIKVRF LLGGRHGDFK FVPPPGYAPC FEAVLPKDRL RIEPIKEYKH DLNGVRNLLG
     PTQSLSHTAF TPNPVDTVQI VLPPHLERIR EKLAENSHEL WAVTRIEQGW TYGPFRDDNK
     KLHPCLVDFQ GLPDPEKNYN LAMSGETLKT LLALGCHVGM GDEKAEENLK RTKLPKTYMQ
     SNGYKPAPLD LNHVKLTPNQ NTLVERLAEN GHNVWARDRV RQGWTYSIVQ DIVNKRNPRL
     VPYNLLDEKT KKTNRDTVCA AVRTLIGYGY NIEPPDQESS GHGVGDGSGN KIRVFRAERS
     YAVTQGKWYF EFEAVTVGEM RVGWARPSVH ADKELGSDDL AYVFNGFKAQ RWHVGSEPFG
     RQWQSGDVVG CMIDLTEQNI MFTLNGEMLI SDSGSEMAFK DIEIGEGFIP VCSLGLSQVG
     RINLGQNVSS LRYFTICGLQ EGFEPFAINM KRDITMWFSK SLPQFVPVPT DHPHFEVSRV
     DGTVDSAPCL KLTHKTFGSQ NANTDLLFFR LSMPIEFHET FKVPAGQTPL TRALTIPEDE
     VLEVDPNSDY ELLKKCATRK EQEEKEKEPS VPKELPGIKE GENEKDTTTE KSKKKGFFSK
     AKKAAFIAPS PVVPTVPRLV EDVVPDDRDD VEIISSTTTY YYSVRVFAGQ EPSGVWVGWV
     TPDYHQYDLH FDLSKVRNVT VTVGDDKGNI HESMKRSNCY MVWGGEFSSS QQTRISQEDF
     VIGCLVDLDT GLMTFAANGK EVNTFYQVEP NTKLFPAVFC LPSSQNMLQV ELGKLKNIMP
     ISAAMFRSDR KNPVPQCPPR LDMQMLTPVI WSRMPNDFLA PDTGRVSEKL GWMVQCTEPL
     TMMALHIPEE NRCIDILELS ERMDLMKFHY HTLKLYGSVC ALGNNRVSHA LCSHVDESQL
     FYAIENTYLP GPIRSGYYDL LISMHLESAK RNRLMTNREF IVPMTDETRS ITLYSDAEKA
     HALPGVGLTT CLRPKLHFAP TGFVGTNADL YTLSPVIPLQ MLKDHALSML TEAVQDGGQA
     MRDPVGGSVE FHFVPILKLI STLLIMGVFE DEDVKHILKL IEPSVFNDSD PPVHEGEEGE
     QPELRREEGA QERKEEKHRE QEDELVDEGV AEEEEEEEEL EEEEEEEEEQ TEREEEGQDA
     LAEKTDREKE TDEEAGLEAE PAVGKEEPKE HEDVGEGLLH MKLPESVKLQ MCTLLQYFCD
     CELRHRVEAI VAFSDRFVNQ VQTNQRQRYN ELMQAFTMSA AETARKTREF RSPPQEQVQF
     ILTLLTSPKN TTSETTTYIL RDHHIHLREL CIRQRPPHTP QGHLHTSETT TYTSKNSAYL
     RDHHIHLDHF WDQELLHQSQ SFLNFLKEEC DQLYQKLSEM ISVGCSLEIP KFLLDMIILK
     LAYNCSIFLN IMSNKVFYQH PNLMRALGMH ETVMEVMVNV LGGGDSKEIR FPRMVTNCCR
     FLCYFCRISR QNQRSMFDHL SYLLQNSGIG LGMRGSTPLD VAAASCIDNN ELALALQEQD
     LEKVVKYLAG CGLQSCPMLL SKGYPDIGWN PCGGEKYLDF LRFAVFVNGE SVEENANVVV
     RLLIRRPECF GPALRGEGGN GLLAAIEEAI KISEDPARDG PSVKKDRRFP MFGGEEQHEE
     NRVHLGNAIM SFYAALIDLL GRCAPEMHLI QAGKGEALRI RAILRSLVPI EDLVGVISLP
     VQIPAFGKDN SIIEPKMSAS FVPDHKAPMV LFLDRVYSID NQDFLLHVLE VGFLPDMRAA
     ASLDTAAFST TEMALALNRY LCSAVLPLIT KCAPLFAGTD HRAIMIDSML HTIYRLSRGR
     SLTKAQRDVI EECLMSLCRY LRPSMLQHLL RRLVFDVPIL NEYAKMPLKL LTNHYERCWK
     YYCLPNGWAN FGVSSEEELH LTRKLFWGIF ESLAHKKYDA ELFKIAMPCI CAIAGAIPPD
     YVDASYSSKT EKKASVDAEG NFDPKPVETT NTIIPEKLDG FINRYAEYTH DKWAFERIQN
     NWTFGEMLDE NAKTHPMLRP YKTFSEKDKE IYRWPIKESV KAMIAWEWTL DKARDGDEDK
     TEKKAARKIS QTAQATYDPS HGYNPQPINI SGMTLSRELQ SMAEQLAENY HNTWGRKKKM
     ELQAKGGGTH PLLVPYDTLT AKEKARDREK AYELLRFLQL NGYAVTRGLK DMEGDVSSIE
     KRFAYGFLQK LLKWMDIAQE FIAHLEAVVS SGRVEKSPHE QEIKFFAKIL LPLVNQYFKN
     HCLYFLSTPA KILGSGGHAS NKEKEMIASI FCKMSALVRH RVFLFGTDAP AIVNCLHILA
     RSLDARTVMK SGPEIVKAGL RSFFESAADD IEKMVENLKL GKVSKGNQPV KGVSQNINYT
     TVALLPVLTS LFDHVAQHQF GDDVILDDLQ MSCYRIMCSI YSLGTVKTPH AERQRPALGE
     CLAHLAAAMP VAYLEPQLNE YNAFSVYTTK TPRERAILGL PNEVQELCLD IPELDILMKE
     IGHLAESGAR YTEMPHVIEI TLPMLCNYLP RWWERGLENF PQLEGQLCTD VTSDHLNQLL
     GSIMKIVVNN LGIDEAPWMK RLAVFSQPIV SRAKPEMLKS HFIPTMEKLR KRTAKVVAEE
     EHLRMEGKSE GDEEEGTIRD EFAVLCRDLY ALYPLLIRYV DNNRARWLTC PDPDAEELFR
     MVGEVFIFWS KSHNFKREEQ NFVVMNEINN MSFLTADSKS KMSKAGGSDV ERTKKKRRGD
     RYSVQTSLIV AALKKMLPIG LNMCSPADQE LINLAKIRYS LKDTDEEVRE FLQNNLHLQG
     KVENPSMRWQ MALYKEMAGK AEDADAPEKV VKRVQEVSAV LYHIEVTEHP FKSKKMVWHK
     LLSKQRRRAV VACFRMTPLY NLPRHRASNM FLDGYKRNWL QTEGYSFEDR MIDDLSKAME
     QEEEEEEETE TKPDPLHQLI LHFSRTALTE KSKLDLDHLY MAYADIMAKS CHMGEEDECE
     EEDQGGGAEE MSFEEKEMEK QRLLYQQSRL HNRGAAEMVL QMISACKGET GSMVSSTLKL
     GISILNGGNS EVQQKMLEYL KDKKDVGFFL SVQALMQTCS VLDLNAFERQ NKAEGLGMVS
     EEGTSKKMKL ESDFQSDDNQ YLFALFCDYY NKNFQNYLRT QTGSTTTINI IICTVDYLLR
     LQESISDFYW YYSGKEIIDE PGKRNFSKAM TVAKQVFNSL TEYIQGPCTG NQQSLAHSRL
     WDAVVGFLHV FAHMMMKLAQ DSSQIGLLKE LLDLQKDMVV MLLSLLEGNV VNGTIARQMV
     DMLVESSSNV EMILKFFDMF LKLKDIVASD AFWDYVTDPR GLISKKDFQK AMDSQKQYTP
     SEIQFLLSCS EADENEMINY EEFANRFQEP AKDIGFNIAV LLTNLSEHVP HDTRLQNFLE
     QAESVLNYFR PFLGRIEIMG ASRKIERIYF EISEVNRRQW EMPQVRESKR QFIFDVVNEG
     GESEKMELFV NFCEDTIFEM NIASQISEQE EEEKGEDDEE IGDTGEGGGG GGGNDEEIGG
     ENGQPESSSA FADFLNGVVN FFGMFTFRNL RRQYRKLRKM TVKEIIISIA TFLWTILLGI
     FHFIFSVCKG LFLLVWHTLF GGSLVEGAKN ITVTEILASM PDPTQDEVHG DLPGEPGAGE
     EQEAGGVMDS AEAAGGEEED EESAEKDVGK IPGIDTPGGL GDMGDTTPVE PPTPEGSPLT
     KRKMQPEETG GEQTTVAEEP PPEPEKADTE NVEKAEKEVE VKTEEPQETL KVEKTSKAKK
     EKKMSREEGF ELWNELDVQR NKFMNYLSRN FYNLRFLALF IAFALNFILL FYRVSDTPPG
     EEFEGSAMFE GSGIFESSGE EIEGSAAEDS MGDDDDEEGP VYYFLEESTG YMQPTLSFLA
     VLHTVISFIC IIGYNCLKIP LVIFKREKEL ARKLEFDGLY ITEQPEDDDI KGQWDRLVLN
     TPSYPNNYWD KFVKRKVLDK YGDIYGRERI AELLGMDLAS LDVSKQQTDK KPEEQDNSML
     AWYSTVSICD ANFFHLMSKA EWVVLNCCMI NLMMTVGLLA VVVYLYTVVA FNFFRKFYNK
     SEDENEPDMK CDDMMTCYLF HMYVGVRAGG GIGDEIEDPA GDEYELYRVV FDITFFFFVI
     VILLAIIQGL IIDAFGELRD QQEQVKEDME TKCFICGIGS DYFDTTPHGF ETHTLEEHNL
     ANYLFFLMYL INKDETEHTG QESYVWKMYQ ERCWDFFPAG DCFRKQYEDQ LG
//
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