ID W5KNT0_ASTMX Unreviewed; 1596 AA.
AC W5KNT0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Si:ch211-241e1.3 {ECO:0000313|Ensembl:ENSAMXP00000009242.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000009242.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000009242.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR STRING; 7994.ENSAMXP00000009242; -.
DR Ensembl; ENSAMXT00000009242.2; ENSAMXP00000009242.2; ENSAMXG00000008991.2.
DR eggNOG; KOG1836; Eukaryota.
DR GeneTree; ENSGT00940000155638; -.
DR HOGENOM; CLU_002814_0_0_1; -.
DR InParanoid; W5KNT0; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000008991; Expressed in zone of skin and 14 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 2.
DR CDD; cd00110; LamG; 3.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009254; Laminin_aI.
DR InterPro; IPR010307; Laminin_dom_II.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF406; LAMININ SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 2.
DR Pfam; PF02210; Laminin_G_2; 2.
DR Pfam; PF06008; Laminin_I; 1.
DR Pfam; PF06009; Laminin_II; 1.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00180; EGF_Lam; 2.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..1596
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017303584"
FT DOMAIN 113..159
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 160..216
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1202..1359
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1400..1571
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1366..1397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 246..280
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 315..360
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 416..698
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 132..141
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 187..196
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1596 AA; 177745 MW; EE580BFA2B4A9D2E CRC64;
MSARCLRIRA LSSGALRLLM ILQLLGLCVA GPRPFHRTPR HPWRDQYPGT QRVQFPSVSD
RESQRIQIPS LSDMDTQRVQ FPSLSDDNDN AGLVTQRCSR GFYRDRSSRC VPCVCNGLSD
DCEESTGRCL NCQYNTAGDH CERCKEGYYG SAALRTCKIC PCPLPQTSNN FAVGCTELLS
GRFQCQCKAG YTGERCERCA PGYYGDPEVF GGRCRPCNCN GNSCSPKTGA CNNGQVPKDI
DPEVGCQECD NCAQTLLNDL DRLEEELLQI KSDLDNMNSS SSAYIRLKKL EEAIADTKNV
VTDYGAAVDR LSPKVTELER DALALTGDIK LLNDKAENRS KDAQAAAENI EKTHEKAKAL
YSQTLDLLAK INELLKLMQN TDWPNGSQPS GDVNKLLAEA ERLVKEMQGR NLKPQNDAAV
KELDEAQKLL EYVKNNCTKQ YNQNLESATR IKDQLNNYEA KLKELEAALK EASSTVQRAN
NQNGLNNKTL SDVMEKMKKL QQEKDSVSKE IVLAKQQLNA TEDLLKMLSD SKKEYEQLAA
QLDGAKTDLT SKINTISQAA AKEGLVKRAE DHAAMLSKLA NDLQQAVKNS SGRTDVQNAL
SAIDAYRNIT EAVKAAEEAA RRAKEAADKA LNDITQGDVT NRAKDLKDES NRLLKDAKNA
AKDLKQATED LTNQKQRLDD AERKKDVLKK ELAAINTDLS GIKRDDIGRM IDAAKRTAAD
ASASANDTLD KLNAIKDEIS KFKATPSSSN VDGLLSDVDM TVKNLSTSIP SLLDKISQVE
KLSSEIDPNN NISNNINRIK DLIEQARAAA NRIMVPMKFN GDGYVELRAP KDLDDLRAYT
ALSILLQRPE DSRGDDLRRR RQTSPGRGNL FVLYLGNRDA TKDYIGMALK SNILIFVYKL
NGKVYEMETD SITPSKGVQS FFDRVDLQRV YQDARIKLTK AFTSTNPPEP QYFEQLGEPL
QNLLNLDPSE VVFYVGGYPD DFTPPAPLQF PKYKGCIEFS SMNEKFISLY NFKSVKPANT
TLPEPCKRYF PPSNDYFEGS GYIKANFGAS ALDRVLIFQQ TFESKAQNAL LMYISNETTS
YWITIERGHF VIRGRVNGKF LQPNITAGTY KLSGDLMVIF QNNERYISVR WKRVAVLQFQ
YTPESFNTYY IGGIPKELRE RDNISTVPLK GCVSNLEADR SSPTIVERVG VGRGCYPDLQ
IIRKAEFHSG SSLKTPAGGF DLSGDVALSL GFRSTDNDGV LLQNRQAISK FELTMQNGFV
MLDFLGSMWK SKKQYQDGEW HYLTVVKNGQ NVEFRIDEDD VGERVTSSTS SANSDLIVLG
NDLFTGCMSN LYMRRPESMY RPEDFSNFNA DGNVFLDLCD AARPPENMLT NPSQSGSQNE
KKDQKENNTS SCFTPTPVPH SLRLAGASST LSYTLPTPLS NGLSFSLDVR TKSAEGLLLY
IPAKQDSYHL ALYVSRGRIR LSMENKGEIF NRETYNDGKW HTVTLSLEKR RYRLVIDGLR
AQDRVLNPGE VQRGSTQLSS NIYLGTPPPS IHEDLKRKKL PDQAVFGCVR DFKMNDSPMP
VAAVNRGVGP CFEGHSESGA YFSQGAYVIV GESAIF
//
