ID W5KSU5_ASTMX Unreviewed; 596 AA.
AC W5KSU5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Methyltransferase like 25 {ECO:0000313|Ensembl:ENSAMXP00000010657.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000010657.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000010657.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KSU5; -.
DR STRING; 7994.ENSAMXP00000010657; -.
DR Ensembl; ENSAMXT00000010657.2; ENSAMXP00000010657.2; ENSAMXG00000010375.2.
DR eggNOG; KOG2651; Eukaryota.
DR GeneTree; ENSGT00530000063745; -.
DR HOGENOM; CLU_016581_2_0_1; -.
DR InParanoid; W5KSU5; -.
DR OrthoDB; 3060170at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000010375; Expressed in testis and 11 other cell types or tissues.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12496; CGI-41 METHYLTRANSFERASE; 1.
DR PANTHER; PTHR12496:SF9; METHYLTRANSFERASE-LIKE PROTEIN 25-RELATED; 1.
DR Pfam; PF13679; Methyltransf_32; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 138..411
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13679"
FT REGION 200..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..338
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 596 AA; 65956 MW; 582C7477B2C48DE2 CRC64;
MAGSALSAEE LKRKIDAVRR FLSVSLSIAN AHTVDFYTRG VWGLFMAVSP EEVLRAVSSA
ADRAGESEVS EDESFGFCNI TRKLVDVEAL LRATRAHSLP GLGVFVQREA VLETLREMCA
EDETCSKPLV PDEFMNSKKA HEVPAMSEVV ASLAKCCGVK QVIDVGSGKG YLCSFLSMQY
DLQVFGIDCS SINTHGAQER NRKLKKFSRA YQRHSKAMKN QDASPKDTDI ETKEDERTNQ
PQRGPSDLDG RGVEESENER NTSVESLFAA SSELVTDSVS VSNGSDSADA DSENSFFAAL
SADIVEQASP RVPPSELSVE ERERRKRDNL ERKARNGRGN TDSSTLFSPL TSYVTAETEL
RTLITELEDA VMVGLHTCGD LAPSTLRMFV AKPELQAVCS VGCCYHLLSE QFDQDGHECE
DGVYGFPMSQ YLREQACFCG RNARMSACLA LERVSVGGGL PMESLFYRAV LHVILRDHYD
AHKSEKRVGN VYSKASSFVD YVRRALRKLD LDESKLSDSE IQSYHDLYSP RMNEMVAFNM
LKVTLAPCIE GLILLDRLCY LKEQESISYS ALVQLFNPLL SPRCYAVVGI KKHGAS
//
