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Database: UniProt
Entry: W5KSX9_ASTMX
LinkDB: W5KSX9_ASTMX
Original site: W5KSX9_ASTMX 
ID   W5KSX9_ASTMX            Unreviewed;      1728 AA.
AC   W5KSX9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   07-JUN-2017, entry version 23.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000010691, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000010691, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000010691};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000010691}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMXP00000010691}.
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DR   EMBL; APWO01111783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01111784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01111785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01111786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAMXT00000010691; ENSAMXP00000010691; ENSAMXG00000010407.
DR   GeneTree; ENSGT00830000128242; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     12     29       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     74     93       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    105    126       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    132    152       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    271    298       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    499    523       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    544    566       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    621    647       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    667    686       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    707    730       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    942    960       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    981   1000       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1058   1084       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1178   1204       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1263   1281       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1293   1311       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1323   1350       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1379   1407       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1481   1506       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       10    304       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      508    734       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      744    936       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      940   1212       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1262   1516       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      306    333       {ECO:0000256|SAM:Coils}.
FT   COILED      358    380       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1728 AA;  197187 MW;  1C3F1786B87D70BD CRC64;
     MKFSLTEAVT WFNMVIMFTI LTNCAFMTMS ESPGWAKIAE YTFTGIYTLE SVIKILARGF
     CIGKFTFLRD PWNWLDFSVI VLAYVTEFVK MGNVSALRTF RVLRALKTIS VIPGLKTIVG
     ALIQSVKKLS DVMILTVFCL SVFALIGLQL FMGHLKYKCI QLPANHTDLG NGSISYNGKA
     VPEDWLKNYT SDPSLYYNLS GKKDPLICGL VRDAGKCPNG YFCSKASRNP NYGYTSFDSF
     GWAFLSLFRL MTQDCWENLY QQTLRAAGKT YMIFFVLVIF LGSFYLVNLI LAVVAMAYDE
     QNQANLAEAQ QKEEEFQAML EQLKKQQADA QAAAAVFESG DFSGEMTDTS SETSKLSSKS
     AKERRNQKKK KKQREEARED EKADSEKTHN SVSEGSIRRP SFRFSPDLNR LPYDRTYTSP
     RQDDTEQEYS MRYDSHQPSP GYLDEQTARQ RALSVASIIT NTMEELEESR QKCHPCWYRF
     AHTFLIWECC PTWMKIKKAV HMVVMDPFVD LSITICIVMN TIFMAMEHHP MDKDFSSVLS
     MGNYVFTGIF TAEMVFKIIA LDPYYYFQEG WNIFDSVIVS LSLMELGLAN ISGMSVLRSF
     RLLRVFKLAK SWPTLNMLIK IIGNSMGALS NLTLVLAIII FIFAVVGMQL FGKSYKTSLT
     KIAPDGFLRW HMMDFLHSFL IVFRVLCGEW IETMWDCMEV HGQPLCLIVF LMVMVIGNLV
     VLNLFLALLL SSFSADNLAA TEDDNEMNNL QIALGRIHRG VAFVKASLRR FFQTVCLRVR
     RKKSSEQNGL KNSKKLPDIS NHTTVELIKD PGSMKDLAGA DSDNENFIMN SSVTVTVPIA
     TADSDAECQN MEDYSSYSSD MEEDKEKLSE VMSSSEGSTV EIRKDGADSL EFELEESMDP
     EPCFTDGCVR RCRCCQVNME KERWRTWWTV RRTCFRIVEH TWFESFIIFM ILLSSGALAF
     EDIYIEGYKT LKMILEYADK VFTYVFMLEM LLKWLAYGFA KYFTNAWCWL DFLIVDVSLI
     SLVANALDYS ELGAIKSLRT LRALRPLRAL SRFEGMRVVV NALLGAIPSI MNVLLVCLIF
     WLIFSIMGVN LFAGKFYECV NITTGIRMNE TDVANKTECD MLGEGNARWK NLKINFDNVG
     AGYLALLQVA TFKGWMDIMY AAVDSRNLNE QPKFEVNLIM YGYFVGFIIF GSFFTLNLFI
     GVIIDNFNQQ KKKFGGQDIF MTEEQKKYYN AMKKLGSKKL QKPIPRPTNK VQGFIFDIVT
     NQAFDIFIMI LICLNMVTMM VESDDPDPKM KTVLNWLNMI FVALFTTECA LKMVSLRQYF
     FTVGWNIFDF VVVILSIVAM CISDVITYFF SPTLLRVVRL ARIGRILRLI KGAKGIRTLL
     FALMMSLPAL FNIGLLLFLV MFIYAIFGMS NFAYVKKEAG IDDMFNFETF GNSMICLFQI
     TTSAGWDGLL SPILNRDIPD CNPTKDNPGS KVKGDCGSPS IGIIFFVSYI IICFLIVVNM
     YIAVILENFS VATEESAEPL SEDDFEMFYE VWEKFDPKAT QFMEYNKLSD FADALDPPLR
     MPKPNKIQLI GMDLPMVTGE RIHCLDILFA FTKRVLGEGG EMDILRGQME DRFMASNPSK
     VSYEPITSTL RRKHEDMSAL VIQRAYRKYV GKHRMKPAPS THKETVQENG KVSDKDSVVR
     NNINNHSTLE PTVCPPSYNS VTQLRKDKYE KDKREKEVKG KDNKEQKK
//
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