ID W5KT29_ASTMX Unreviewed; 639 AA.
AC W5KT29;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=TBK1 binding protein 1 {ECO:0000313|Ensembl:ENSAMXP00000010741.2};
GN Name=TBKBP1 {ECO:0000313|Ensembl:ENSAMXP00000010741.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000010741.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000010741.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KT29; -.
DR STRING; 7994.ENSAMXP00000010741; -.
DR Ensembl; ENSAMXT00000010741.2; ENSAMXP00000010741.2; ENSAMXG00000010457.2.
DR eggNOG; ENOG502QVP4; Eukaryota.
DR GeneTree; ENSGT00940000153704; -.
DR HOGENOM; CLU_029090_0_0_1; -.
DR InParanoid; W5KT29; -.
DR OrthoDB; 4174931at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000010457; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR041641; CALCOCO1/2_Zn_UBZ1.
DR InterPro; IPR024581; TBD.
DR PANTHER; PTHR14432; PROSAPIP2 PROTEIN/5-AZACYTIDINE INDUCED GENE 2; 1.
DR PANTHER; PTHR14432:SF2; TANK-BINDING KINASE 1-BINDING PROTEIN 1; 1.
DR Pfam; PF12845; TBD; 1.
DR Pfam; PF18112; Zn-C2H2_12; 1.
DR PROSITE; PS51905; ZF_UBZ1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01253}.
FT DOMAIN 607..633
FT /note="UBZ1-type"
FT /evidence="ECO:0000259|PROSITE:PS51905"
FT REGION 321..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 48..75
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 104..162
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 224..272
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 344..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..506
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 639 AA; 72203 MW; C2C124E4FF6D88B9 CRC64;
MESLFGGELG LLGGSEGLKE DGCGVGWSGS PSPEDMYSAS HFALISAYQD IKTRLVGLER
ENTDIKRKLK IYEIKFPMIG DFGDDRNSYC SFEPKDTALL QSENGNLQQR INILTHELQK
SKEREEQLED VIQAYEKIHM EKSNLQRDLD KMTSLVEKHV ERIHSLESAL RQRESSLHKL
NTQLHSKDMQ YLQLHASPDT HRLDCPALTL QSSRSLDTLS DLKLQQLEAE LEGARHEAQG
ACQREEELKA ECERLQEELR ELQNNQRQRE VNSTCAQCDV EWIKKVGDEQ VNLALAYTEL
TEELGKLQAL SAKQTEILRK ASQEQASPVQ RHSPVPLQRH SPVPQRHSPI QQRHSPIQQR
HSPVPQRRSP VLQRLSPDMH RRSPLPEISD GPASYSCRPT IHHLRASFQG RRSYSEVADP
SAYQRPPRFT LDPVSTLPKP RPYVESYHKQ QSPQQSQQQQ QQQHGGSPHI LSQRRGSQPG
LQVVGGEGSL AESPRHSREL SFQHQELSHL HYEPQPGPAP LHSSPQPPHS SEDEEEWTCP
HPISPPRTLG ASGPASSMRG PASCSAFPIP ARPNTLSCHP PGYLHAEHAQ SWPSINLWME
TEEESDVRSC PLCQVIFPIG YPDDALIKHI DSHLENSKI
//
