ID   W5KV56_ASTMX            Unreviewed;      1997 AA.
AC   W5KV56;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   28-MAR-2018, entry version 22.
DE   SubName: Full=Ryanodine receptor 2b (cardiac) {ECO:0000313|Ensembl:ENSAMXP00000011468};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000011468, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000011468, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000011468};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000011468}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
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DR   EMBL; APWO01075288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01075289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAMXT00000011468; ENSAMXP00000011468; ENSAMXG00000011163.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; ENETHEE; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   Pfam; PF02026; RyR; 2.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   PROSITE; PS50188; B302_SPRY; 3.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT   DOMAIN        1    147       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      368    562       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      686    893       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   1997 AA;  222474 MW;  D3EC9A5A9D0719DB CRC64;
     MGDDSAQHRK WYYEVVVEKA QPFVTAEPTH LRVGWACTAG YRPSPTGGHG WGSNGVGDDL
     CSYGFDGLHL WTGGTGRRVS SLNQHLLRED DVISCCLDLS ASCISFRVNG QPVQGMLENF
     TADGLLFPVV SFSAGVRVRL LFGGKQGEFK FLPPSGFSPC AEALLPGGRC RLELCEEFTR
     FQGSGQCDLL GPTVPLGPVI FTPTPVDTSQ LVLPPQLEII RERLAENLHE LWLLDKIEQG
     WTHGPVRDDS KKVHPGLAEF SKLPEQERQS NLQATENTIR TLLALGAHIG LSEDHAEENV
     KYVRLSNKYE LCNGYRPTPV DQSGISLSAG QEALVEALTE NEHNLWARER IRQGWSYATQ
     LDVKGKRSPQ LVPFSLLEER IKCCSREAAR DALGTLLGLG YAVESTEHQQ ALTGPEVKTA
     GEETFRIFCV EHSFAVWDGK WYFEFEVVTD GEMRVGWAQP GSKPDVELGS DDQAFVFDGC
     KGQWWHGSAV RLGRPWQEGD VIGCLLDLSQ KTMMVTLNGE LQLNSCGSEI AAKDFSVSGG
     FLPVCSLGVN QVGRLNLGRQ FDSLKYFSVC GLQEGYQPFG LNMSRDLPLW MSWKEPMFVS
     ILEDHTSIQV TRTDGTADCP PALRFSQKSV VAPDSTAVEF YRLSMPIECA QVFSKPAEGA
     VPASSSVICH ARELDEGEVD SDFEVLMKSV HRYTGSRDEL NNHKDHTQEK PSKLKQRFLL
     KKKPELNTSG SSARLLEEVL AIERDDCNQL TGCTKYYYSL KILNGQEPSC VWVGWITSTF
     HPPEQPFDLE KVHTVMVTLG DDWGKVLESV RRSCCYMVCA AAEGSSLSHS RSSSGLEIGC
     LVDTATGLLT FTANGKDMET FFQVEPGTKL FPAVFAKATS LDVFQFQLGR IKGVLPLSAG
     MFRSERNNAV PQCPPRLSVQ RLTRARWARL PDHSPHVQLT RLGEGHGWRA QCTDSLQVMT
     LYIPEEERCL DILELSELEH LLKFHEHTLN LYSALCAHGN LHVSHALCSY IDQSQLLFAL
     QCPRMPGTLR ESFYNLLTSA HLSAHASAQQ ATTHEYIVPM TDTTRSIALF KSDGKRHSLP
     GSDISTLLRP RMHFSSPCFI SSSNPIQAGS PPGFPLDILK GVTTAMLEEA VHAVGQSVRD
     PIGGSIELLL VPLLQLLHTL LLMGVFQGSD LRRVLSLILP SAYMGENDME RWADGDEEGN
     GEKKDEDKER WVSVPLLELQ MKLPEAVKLK LCHLLQYLCD CQVRHRVEAV LAFSDDLVDH
     LQDNQRYRYN EVMEALNMSA ALTARKTKEF RSPPQEQMNM LLNFQESQQE CPCPEEIKDL
     LWDFHIDLRR HCEVEVDDED QATKDEVDPP NRYRLKGLVD RIVRLKRRMS GIVEEDIVTK
     SVSLQQLISD TMLRWAHEGL LENPTLVRAA FSLLQWQYAG LSGQMAAPLR KAYCISQSSV
     EDTLYLQEAL GRIRSLLRAR MGREEEELMI RGLGDIMKNK VFYQHPNLMR ALGMHETVME
     VMVNVLGARE SKEIMFPKMV AHCCRFLCYF CRISRHNQKA MFDHLSYLLD HSSVGLASPS
     MRGSTPLDVA AASVMDNYEL ALSLTEADLE KVVQYLAGCG LRSCSLLVSK GYPDIGWNPV
     EGERYLDFLR FAVFCNGESV EENAYVVVRL LIRRPECFGP ALRGEGGDGL LATMEEAIRI
     SEDQNRDGSS RVYYSSSTLD TLDDEDDDII HMGHAIMTFY SALIDLLGRC APEMHLIEAG
     KGEAVRIRAI LRSLIPVKDL EGVISIPFSL PFVDTDGSVM EPDMSRLFCP DHKAAMVLFL
     DRVYGVQDQN FLLCLLKNGF LPDLKAAVTM DTSGLGGTDM ALALNRYVCV AVLPFLSKNS
     SLLCDPTPAQ TTAVDALLQE LYSLSKASGL TKAQRDSIQD CLLCVCGKLK PSLVQPLLQN
     LVLDVPQLTE NTKMPLKLLT NHYEHSWKYY CMAGAQGGSG SASEEELQLS RKLFWAVFRA
     LSKKVGLSNC SSMLLSL
//