ID W5KXH4_ASTMX Unreviewed; 393 AA.
AC W5KXH4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=Glucose-fructose oxidoreductase domain-containing protein 1 {ECO:0000313|Ensembl:ENSAMXP00000012286.2};
GN Name=GFOD1 {ECO:0000313|Ensembl:ENSAMXP00000012286.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000012286.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000012286.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family.
CC {ECO:0000256|ARBA:ARBA00010928}.
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DR AlphaFoldDB; W5KXH4; -.
DR STRING; 7994.ENSAMXP00000012286; -.
DR Ensembl; ENSAMXT00000012286.2; ENSAMXP00000012286.2; ENSAMXG00000011955.2.
DR eggNOG; KOG2742; Eukaryota.
DR GeneTree; ENSGT00940000160837; -.
DR HOGENOM; CLU_023194_8_0_1; -.
DR InParanoid; W5KXH4; -.
DR OrthoDB; 2899892at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000011955; Expressed in brain and 9 other cell types or tissues.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43818; BCDNA.GH03377; 1.
DR PANTHER; PTHR43818:SF2; GLUCOSE-FRUCTOSE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 7..117
FT /note="Gfo/Idh/MocA-like oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01408"
FT DOMAIN 134..269
FT /note="Gfo/Idh/MocA-like oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02894"
SQ SEQUENCE 393 AA; 43365 MW; 7F30EB811ED6CF6E CRC64;
MAMLPGVGVF GTSLTARVII PLLKNEGFSV KALWGRTQEE AEELAKEMNV PFYTNRIDDV
LLHQDVDLVC INLPPPLTRQ IAVKTLGIGK NVICDRTATP LDAFRMMSAA QYYPKLLSIM
GNVLRFLPAF VRMKELLEEG YVGELLVCEA QVHGGSLLGK KYNWSCDDLM GGGGLHSVGS
YIIDLLTFLT GRRAAKVHGF LKTFVKQTDH IKGIRQITSD DFCTFQMVLE GGACCTVTLN
FNVPGEFRQE VVVVGTAGRL TVSGTDLYGQ KNSGEGGREL LLKDCTPLGN ASLPDKAFSD
IPSPYLTGTI CMVQAVRQAF QDQDDRRTWD GRPLTMAATF EDCLYALCVV DTIKKSNQCG
EWQNIVVMTE EPEVSPAYLI SEAMRRSRMS LYC
//