ID W5KZF4_ASTMX Unreviewed; 525 AA.
AC W5KZF4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Neuralized E3 ubiquitin protein ligase 1Aa {ECO:0000313|Ensembl:ENSAMXP00000012966.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000012966.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000012966.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KZF4; -.
DR STRING; 7994.ENSAMXP00000012966; -.
DR Ensembl; ENSAMXT00000012966.2; ENSAMXP00000012966.2; ENSAMXG00000012612.2.
DR eggNOG; KOG4172; Eukaryota.
DR eggNOG; KOG4625; Eukaryota.
DR GeneTree; ENSGT00940000156696; -.
DR HOGENOM; CLU_013230_1_0_1; -.
DR InParanoid; W5KZF4; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000012612; Expressed in camera-type eye and 9 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.920; -; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR037962; Neuralized.
DR InterPro; IPR006573; NHR_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12429:SF13; E3 UBIQUITIN-PROTEIN LIGASE NEURL1; 1.
DR PANTHER; PTHR12429; NEURALIZED; 1.
DR Pfam; PF07177; Neuralized; 2.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00588; NEUZ; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51065; NHR; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 7..163
FT /note="NHR"
FT /evidence="ECO:0000259|PROSITE:PS51065"
FT DOMAIN 241..397
FT /note="NHR"
FT /evidence="ECO:0000259|PROSITE:PS51065"
FT DOMAIN 472..512
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 398..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 525 AA; 57180 MW; 6A97CC04381CB7FB CRC64;
MGLPVSPLLF HPSAKGSQIV MDLAQRTVKR QASFCNAITF SNRPIALYEQ VRLKITKKQC
CWSGALRLGF TSKDPSRINP DSLPKYACPD LVSQSGFWAK ALPEEFANEG NLVAFWVDKK
GRVFYRINDS SPMLFFSGVR TVEPLWALID VYGLTRGVQL LDSEIVPPDC LRPRSFTTVR
GGSSLRREAD ASRLSVSLCD LNLQQDEARL RLPPAPAACP IPQNSLNSQQ SSFLPPTLES
DLRFHQLRGA HIKTLDEQTV ARSEHAGQRE ERTLVFTERP LRSGETIFIK VTKSSPARSG
SLSYGVTSCD PSALRPSDLP YNPEALVDRK EFWAVCRVPA VLQTGDILGF LVTQEGEVTL
SHNGVSAGMQ VCVDNSRPLW MFFGLHGAVT QLRILGSTHH GETRGPSSPS SPSSSPHSPG
GGLCSGSSEP TLNGGCSGAF CSSVVGTNPS SPINLPKSPT FPSSSSSWPD ECSICYENAV
DTVIYACGHM CLCYTCGLRL KKMANACCPI CRRAIKDIIK TYRST
//
