ID W5L0A1_ASTMX Unreviewed; 721 AA.
AC W5L0A1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000013263.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000013263.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU000633};
CC Single-pass type I membrane protein {ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR AlphaFoldDB; W5L0A1; -.
DR STRING; 7994.ENSAMXP00000013263; -.
DR Ensembl; ENSAMXT00000013263.2; ENSAMXP00000013263.2; ENSAMXG00000012901.2.
DR eggNOG; KOG1226; Eukaryota.
DR GeneTree; ENSGT01090000259987; -.
DR HOGENOM; CLU_011772_0_0_1; -.
DR InParanoid; W5L0A1; -.
DR OrthoDB; 5475862at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000012901; Expressed in mesonephros and 4 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR040622; I-EGF_1.
DR InterPro; IPR033760; Integrin_beta_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF36; INTEGRIN BETA-7; 1.
DR Pfam; PF07974; EGF_2; 2.
DR Pfam; PF18372; I-EGF_1; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR Pfam; PF17205; PSI_integrin; 1.
DR PIRSF; PIRSF002512; Integrin_B; 1.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00187; INB; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 2.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|RuleBase:RU000633};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..721
FT /note="Integrin beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017360552"
FT TRANSMEM 684..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..447
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 448..482
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 498..531
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 536..568
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 575..607
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DISULFID 30..39
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 33..69
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 42..58
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 190..196
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 244..284
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 445..449
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 467..508
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 472..481
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 483..499
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 514..519
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 516..545
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 521..530
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 532..537
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 551..556
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 553..584
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 558..567
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 590..595
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 592..633
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 597..606
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 613..622
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ SEQUENCE 721 AA; 80123 MW; F30DA890DB2B2DB4 CRC64;
MLRRQIFTVV FMFCILFQGT EGQCSSKLTC SECVQHAGCA WCKQRGFLSP GQPDRRRCDT
AEGLRRRNCS AIIDPTPDVQ SIVDTELGSS LENVVQLRPQ KLHLKLRVGV PQTFKVAFKR
AEGYPIDLYF LMDFSLSMID DLENMKKLGH KVMSALRNVT NAARIGFGAY VDKREIPFIT
SSSDSLSNPC PENKTCQPAF SFKHFLNLTD NMEDFEKEVS KQNISVNEDL PESGFDGVMQ
VSVCEEEIGW GNVTRILVYL SDGLFHSAGD GRLAGIVRPN DGKCHLNKDG LYETSESYDY
PSIAHLSEVL AKKNIKIIFA ITDDYQDTYQ ELSAVIPQSV VGILESDSSN VVQLISDAYN
DLVSKLILEH HKAPAGLDIS YSSECSDGTQ SYGQKRGECR NLDFDQQINF TVTVSTSVCF
SHARSFTIRP QGLTEELSVT VETLCDCDCR DTERRSSYCH GNGTYACGAC SCDEGYVGQT
CECEKQQNAD SILSMEALCT PFNSTNTCSG HGSCLCGRCI CHSHYRGQYC QCDDTSCNHH
KNLICGGNGR CNCGTCECYP NYEGPACECS TITDECQTGN DSICSNHGYC ECNQCICHPD
FKGKHCTMSL YPCLQYGACV RCRLSNVLEK ENCEEACSST ELIHSPDARI FSCDDEMVFF
NVESNSETVQ IFYREKHSIF QRAMFGTLVI FCSGVGGVVI LGTTMILTYL VLLNIYYQIV
P
//
