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Database: UniProt
Entry: W5L133_ASTMX
LinkDB: W5L133_ASTMX
Original site: W5L133_ASTMX 
ID   W5L133_ASTMX            Unreviewed;       884 AA.
AC   W5L133;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 54.
DE   SubName: Full=Lysine demethylase 7A {ECO:0000313|Ensembl:ENSAMXP00000013545.2};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000013545.2, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000013545.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|ARBA:ARBA00001954};
CC   -!- SIMILARITY: Belongs to the JHDM1 histone demethylase family. JHDM1D
CC       subfamily. {ECO:0000256|ARBA:ARBA00006942}.
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DR   AlphaFoldDB; W5L133; -.
DR   STRING; 7994.ENSAMXP00000013545; -.
DR   Ensembl; ENSAMXT00000013545.2; ENSAMXP00000013545.2; ENSAMXG00000013160.2.
DR   eggNOG; KOG1633; Eukaryota.
DR   eggNOG; KOG1634; Eukaryota.
DR   GeneTree; ENSGT00940000158039; -.
DR   HOGENOM; CLU_003540_2_1_1; -.
DR   InParanoid; W5L133; -.
DR   OrthoDB; 2784357at2759; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000013160; Expressed in camera-type eye and 14 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   CDD; cd15640; PHD_KDM7; 1.
DR   Gene3D; 1.20.58.1360; -; 1.
DR   Gene3D; 2.60.120.650; Cupin; 1.
DR   InterPro; IPR041070; JHD.
DR   InterPro; IPR003347; JmjC_dom.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   PANTHER; PTHR23123:SF15; LYSINE-SPECIFIC DEMETHYLASE 7A; 1.
DR   PANTHER; PTHR23123; PHD/F-BOX CONTAINING PROTEIN; 1.
DR   Pfam; PF17811; JHD; 1.
DR   Pfam; PF02373; JmjC; 1.
DR   Pfam; PF00628; PHD; 1.
DR   SMART; SM00558; JmjC; 1.
DR   SMART; SM00249; PHD; 1.
DR   SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   PROSITE; PS51184; JMJC; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00146}.
FT   DOMAIN          5..56
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50016"
FT   DOMAIN          198..354
FT                   /note="JmjC"
FT                   /evidence="ECO:0000259|PROSITE:PS51184"
FT   REGION          443..501
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          625..721
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          735..872
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        450..473
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..496
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        625..658
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        665..679
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        680..699
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        700..714
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        736..757
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        793..810
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   884 AA;  101145 MW;  7CAB22B7455A4017 CRC64;
     MATAPLYCVC RQPYDVSRFM IECDICKDWF HGSCVRVEEH HAVDIDVYHC PNCEVPHGPS
     LMKQRKNWHR HDYTEPDDGS KPVQAGTFVF VQELQNRTFA SGDELLVRMQ GSQVTQRYLE
     RHGFRYPIAV AQLDGLGLRL PPSDFSVKDV ERYVGGDKVI DVIDVARQAD SKMKLKEFVK
     YYYSPQRPKV LNVISLEFSD TKMSELVVVP DIAQKMSWVE NYWPDDSYFP KPFVQKYCLM
     GVKNSYTDFH IDFGGTSVWY HVLWGEKIFY LIKPTPTNLA LYEEWSSSPN QSEVFFGEKV
     DTCYKCVVRQ GTTLFIPTGW IHAVLTSQDC MAFGGNFLHN LNIGMQLRCY EMERRLKTPE
     LFKFPYFEAI CWYVAKNLLE ALKELREDNC LPPDYLAKGV KALITALKNW LRREVTEPAS
     EVPDHIRPNH LIKELTKEIR HLEDDQNGSG GSKPVKTQES LTCPSTRSSH ERTFQARSNA
     RRLRHHHHHH HHHHTPKAPS NLDIFEQHTQ EVLKRLEIEP FEEDDSSFGL KANSKFNKVS
     TASTAAAERN LDNHLHLVLC NGRIIKDERW HVREKNMAEH EGVDEQKRYT VKVKMEVKEE
     VLDKQRFTAG HRKLSVIREI CKQESRDLRD DESGVSSDSE SEGHGFKTKK LQSSDEDSES
     SSKEEEEEEV VRKKSVLIKN ETECSSSSPT NSSSISQQHE HSDKNLKRDL SSSPSAEEDA
     IAGMLSMAGL LYPHQSEEGA NSQGSWWSCT THPSPDYNGK EPVSGEENPD SDSNSTISQE
     EWRVRKQQRR ESQSLMDSQG SCSSSEAWGS HTHSPEREDS LPSGYQYCET SLSPPLHPSK
     RPAPNPPPIS NQATKGKRPK KGMATAKQRL GKILKLSRHK SFFV
//
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