ID W5L610_ASTMX Unreviewed; 2396 AA.
AC W5L610;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Myosin IXAb {ECO:0000313|Ensembl:ENSAMXP00000015272.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000015272.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000015272.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, growth cone
CC {ECO:0000256|ARBA:ARBA00004624}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 7994.ENSAMXP00000015272; -.
DR Ensembl; ENSAMXT00000015272.2; ENSAMXP00000015272.2; ENSAMXG00000014841.2.
DR eggNOG; KOG1453; Eukaryota.
DR eggNOG; KOG4229; Eukaryota.
DR GeneTree; ENSGT00940000154905; -.
DR HOGENOM; CLU_000192_2_2_1; -.
DR InParanoid; W5L610; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000014841; Expressed in brain and 14 other cell types or tissues.
DR GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0000146; F:microfilament motor activity; IEA:InterPro.
DR GO; GO:0048675; P:axon extension; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0098529; P:neuromuscular junction development, skeletal muscle fiber; IEA:Ensembl.
DR GO; GO:0036269; P:swimming behavior; IEA:Ensembl.
DR CDD; cd01385; MYSc_Myo9; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 3.
DR Gene3D; 1.20.58.530; -; 2.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR046987; Myo9.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR036023; MYSc_Myo9.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46184:SF3; UNCONVENTIONAL MYOSIN-IXA; 1.
DR PANTHER; PTHR46184; UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Zinc {ECO:0000256|ARBA:ARBA00022771};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 16..114
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 149..1018
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1933..2121
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 780..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 900..922
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1163..1184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1201..1246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1323..1385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1463..1482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1539..1569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1598..1717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2145..2199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2226..2384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..814
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1163..1180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1544..1568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1644..1660
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1697..1717
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2185..2199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2239..2264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2265..2286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2290..2320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2349..2377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 242..249
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2396 AA; 273886 MW; C71708FD714A6C0C CRC64;
IMSCHDAGGR RRFEDTEFTL HIYPGTLSEG TIYCPVSARK VTSAAEVIEQ VIERLRLDRA
RLYVLAEVKE FGGEEWILNP GDCPVQRMML WPRMALENRI SGEDYRFLLR EKNVDGSIHY
GSLQMWLRVT EERRRLVERG LLPQPPAGQL ASDLCALPDL NERTLLENLR GRFRQEKIYT
YVGGILIVVN PFKFLPIYNP KYVKMYDNHQ LGKLEPHIYA VADVAYHAML QRRRNQCIVI
SGESGSGKTQ STNFLIHHLT ALSQKGFASG VEQIILGAGP VLEAFGNAKT AHNNNSSRFG
KFIQVNYQES GTVRGAYVEK YLLEKSRLVY QEHNERNYHV FYYLLAGASE EERKAFHLLR
PEEYHYLNQM TKKAHRLHWE NYCESELDCF SVEGEDLKHD FERLQLAMEM VGFLPATRKQ
ILSLLSAILL LGNIQYKKKT YRDDSIDICN PEVLPTISEL LEVKEEMLFE ALTTRKTVTV
GERLIVPYKL AEAGTVRDSM AKSLYGALFD WIVFRTNHAL LNNKDLEDSA KILSIGVLDI
FGFEDYENNS FEQFCINFAN ERLQHYFNQH IFKLEQEEYR AEGISWHMID YIDNTSCINL
ISKKPTALLH LLDEECNFPQ ASNQTLLDKF KRQHDGNSYI EFPAVMEPAF IIHHYAGKVK
YSVKDFREKN TDHMRPDIVA LLKSSKSAFI CGLMGIDPVA TFRWAVLRAY FRAVVAFRGA
GKWHREKKSG SDSAVQCTVI KSVDSFSFLH HPVHQRSLEI LQRCKDDKYN SCITRRNPRS
PLSDLQGTNT LNEKSTRDGF SGCNGRSSRP GRLATTGSAH EEDGIFVNAM SNRLLERAQG
ILMRNKNYKA KPSLPKHLLD VKSLKHLSSL TLHDRITKSL LHLHKKKKPP SISAQFQASL
NKLMETLGQS EPYFVKCIRS NAEKLPLRFN DALVLRQLRY TGMLETVRIR QSGYSVKYTF
QDFAHHFHVL LPDGTGASQA GIREFLKRAD LDPDGYQVGK TMVFLREVQR QRLQDLLHQE
VLRRIVMLQR KFRALLERKL FINQRQAALV IQHWWRKCML CHSRDRADAS ELRHGAAVCL
QAAWRGYKER KLYLLQRDAV LLLQRGWRRC MQRRWRAAGL IQATWRAHRQ RQRYLQLCRA
IITLQAACRG HQARQRCRCL REEQKTHSEN NKEQSTTPED LQDFQKRTSA QITDLHLEEL
HQSSETSQEE HRMEFSESLS SEHCKTLDDS TLKSRAKRES RRKRELEQAT FSLELLKVRS
NNVPLSDQPV PLKTAPPYSS PQSSFDSHGS FELLIVDDAK LEELDHHHPD LVPIDQSISV
EDNKREHKTV SEVKTTPVKR LEPSSPIQPA GQRTSKALFY ISDEGSSPVS PEPQTPSRSK
AARDRKESVV VLISMQKESP VDPSSLEALE RLEQEAECKP NIAQQESTCS SIRFGQAPLN
QPTVQPSQAP LDLRLNLELS SGAATLPSGS ATREASSEAR KEEGMGLMQA QKKAVMHSIS
ISMKEKATNL AFSPKRSRLT FSKSDKDLAN QERSLALQRE RTSGFRSLKS REVARGGRPK
KARMARTRSD FLTRACSTEA DSDDEDDDDY EYRRVLSHTL PLPEPPGSPT TDQAFHSDSE
MPSQKEQKRL QKTMSSGDLG KVDSLRKSSS HTDSSRVRGK MRFWGKGKHS EKKMSTRGRS
AEGDLTKAGN DSPPRSPERS GGRDHGRDSK ENREPEVKMM MMTMRRRRSL KISSITQEPT
PWQSDSLVIL TCTADYRSMN DFLMKKINDL ETEDSKKDSP VDVVFKKALK EFRLNIFNSY
STALAMDDGR SIRYKDLYAL FEHILEKSMR LEQRDWSESP VKVWVNTFKV FLDEFMTEYK
PMDNTIGRAP KPERKKRRKK ETDIVEEHMG HIFKSTQYSI PTYCEYCSSL IWMMDRACVC
KRELLHIGMQ FGVELSRLTS DERAVPLVVE KLINYIEMHG LYTEGIYRKS GSTNKIKELK
LGLDTDANTV NLDDYNIHVI ASVLKQWLRD LPNPLMTFEL YDEFLRATGL QDKREVVKGV
YTVIDQLSRT HLGTLERLIF HLVRISLQEE TNRMSANALA IVFAPCILRC PDSTDPLQSV
QDIGKTTACV EMIICQQMNK YKARLKDINT LEFAESKAKN RLTHIRRSMG KARIRRSSHH
TPSPPMSPRS PVVAEPEVPE DEGVESSLSD QQQAAMQQEE TVLTQQIESL QKEKEELTYE
MLALEPRASD DEMLESEASI GTADSSENLM AEQEGATSET WEKNCSTLRS RKTDSKSRRA
LRRQPESLDS VDSAVASLSS TSSTPHYRFR SSSSGPLFSS ASGLDHPHLA EQEASEQPVL
NTRCASSSEK TRPRTRGNRS CPPKPRESGE GGGRRRDTEF GSVQPLVLYG SNEFMV
//
