GenomeNet

Database: UniProt
Entry: W5L7L9_ASTMX
LinkDB: W5L7L9_ASTMX
Original site: W5L7L9_ASTMX 
ID   W5L7L9_ASTMX            Unreviewed;       512 AA.
AC   W5L7L9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   25-OCT-2017, entry version 20.
DE   SubName: Full=Transmembrane phosphatase with tensin homology {ECO:0000313|Ensembl:ENSAMXP00000015831};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000015831, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000015831, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000015831};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000015831}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMXP00000015831}.
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DR   EMBL; APWO01095973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01095974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01095975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01095976; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAMXT00000015831; ENSAMXP00000015831; ENSAMXG00000015223.
DR   GeneTree; ENSGT00760000119113; -.
DR   OMA; YFWFNTS; -.
DR   OrthoDB; EOG091G09VG; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:Ensembl.
DR   GO; GO:0016314; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; IEA:Ensembl.
DR   GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:Ensembl.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR014020; Tensin_C2-dom.
DR   InterPro; IPR029023; Tensin_phosphatase.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF10409; PTEN_C2; 1.
DR   SMART; SM01326; PTEN_C2; 1.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS51182; C2_TENSIN; 1.
DR   PROSITE; PS51181; PPASE_TENSIN; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     56     79       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     91    110       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    122    141       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      191    363       Phosphatase tensin-type.
FT                                {ECO:0000259|PROSITE:PS51181}.
FT   DOMAIN      375    512       C2 tensin-type. {ECO:0000259|PROSITE:
FT                                PS51182}.
SQ   SEQUENCE   512 AA;  58793 MW;  338F3D8C4DE08714 CRC64;
     MTSVHFNPGL DSKDVNGNGT MEEAQVQIDD GKEGNEEPDT FYYRTRKRIA PFVMSFGFRV
     FGVVLIILDI ALVIVDLSLP DQNEVRTPLE AISLVISFFF VIDVLLRVYV EGFKVYFSSK
     LNIMDACIVF ITLIVTMIYT FSNFSGTNLI PRVVSFLRAL RIVILVRVFR LASQKKELEK
     VTRRMVSENK RRYQKDGFDL DLTYVTDRVI AMSFPSSGKQ ALYRNPIKEV ARFLDTKHPD
     HYRVYNLCSQ KGYDPLLFHY RVQRVMIDDH NVPSLDTLIK NTCSVRPWVG FGQRTNVIAI
     HCKGGKGYSK TQVYALYSSQ IQTLHLFCYF SLLSFSANKC SKVFGVEMQY SYSLYFCTFY
     REVSHGVINL KKPKPSGCRV VTLVTHLVCS LIDGRGARLK KHTSLRCELC HLFCCSMLNC
     TLFPDTENNA VVISLQEGPV VCGDVKVMFE SRAAQGLPKG YEDYPFYFWF NTSFVENNRL
     YLSREELDNP RKSKTWDIYK EDFGVTVSFS DP
//
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