ID W5L8Z4_ASTMX Unreviewed; 1362 AA.
AC W5L8Z4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=WD repeat domain 7 {ECO:0000313|Ensembl:ENSAMXP00000016306.2};
GN Name=WDR7 {ECO:0000313|Ensembl:ENSAMXP00000016306.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000016306.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000016306.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 7994.ENSAMXP00000016306; -.
DR Ensembl; ENSAMXT00000016306.2; ENSAMXP00000016306.2; ENSAMXG00000015805.2.
DR eggNOG; KOG4155; Eukaryota.
DR GeneTree; ENSGT00940000155301; -.
DR HOGENOM; CLU_004362_1_0_1; -.
DR InParanoid; W5L8Z4; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000015805; Expressed in brain and 14 other cell types or tissues.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44099; RABCONNECTIN-3B, ISOFORM A; 1.
DR PANTHER; PTHR44099:SF3; WD REPEAT-CONTAINING PROTEIN 7; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 60..104
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 459..506
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 555..596
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1262..1298
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 900..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1013..1045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1021..1035
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1362 AA; 150007 MW; D7F48516A6EA5F7A CRC64;
MSGNSLVLPI VLWGRNAPTH CISSLLVMDD LATIISGCHD GQICIWDMTP DLKINPRALL
FGHTASVTCL SKASASSDKQ YMVSASESGE MCLWDVNDGR CIEFTKLACA HTGIQFYQFT
IGTQREGRLL CNGHYPEILV VDATSLEVLY SLVSKISPDW ISSMSIIRSH RTQEDTVVAV
SVTGILKVWI ITAEVSRMQD MDPVFEEESK PIYCQGCQSI SFCTFTQLSL LVVCSKYWRV
FDAGDFSLLC SVPSENDQSW TGGEFIAADK VIIWTEDGCS YIYKLPASCL PASESFRSNV
GKTAEGSIPP LVYSIADRAD KQLLICPPVT RFFYGRREPF HKLLVQGDSA GRLSLWSIPD
TSPLQPLSSL QVSSTISLQE AFDKLTPLPA GIIDQLSVLP GSEDPVKVTA SVYIPSQGRL
VCGREDGSIV LVPATQTAIV QLLQGEHMLR RGWPPHRTLR GHRNKVTCLL YPHQISPRYD
QRSLVSGGVD FSVIVWDIFT GEMKHIFCVH GGEITQLLVP PENCSTRVQH CVCSVASDHS
VGLLSLRERK CIMLASRHLF PIQVIKWRPC DDYLVVGCSD GSVYVWQMDT GALDRCVMGI
TAVEILNACD EAVPAAVDAL NHPAVNLKQA MTRRSLAALK NMAQHKLQTL ATNLLAADNA
DKGNLPKYSH NALMVQAMKT NLTDPDMHVL FFDVEAVIIQ LLTEEAQRPN PTLVSPETLQ
KAPGGVDKGG SFLANKIFKQ VKETIKENIK EHLLDEDEDE EEEMRRREEK SKSLSLLEYN
LTMDTAKLFM SCLHAWGLNG TLDEVCMSRL GMLRPHTPIS FGLISRGGHM SLMLPTFKDS
LLRQLYQGAA EGRKLSVSEI VGKGTYGVSR AVTTQHLLSV ISLANTLMGM TNATFVGEHM
KKAPARPPRP GTPETPRKTA PQVSNPALQG QIKQGWSQLA AMHCVMLPDL LGLDKFRPPL
LEMLARRWQD RCLEVREAAQ ALLLAELRRI GQSGRKDTID AWAPYLPQYV DVVSSPGTAP
ETAQPTPPPP EAPPAEPKAP EEEMDVTDDD ITAGKALTFL LLQPPSPKLP AHSTIRRTAI
DLIGRGFTVW EPYMDVSAVL MGLLELCADH HNGLPLNPAA DSARSARHAL SLIATARPPA
FITTIAKEVH RHTAMQSQGS QSQQNVHTTT LARAKTEILR VIEILIEKMP SDVVDLLVEV
MDIIMYCIEG SLVKKKGLSE CFPAICKFYM VAYCDRSYRV AVGARQGSVA LYDVRTGKCQ
HIHGHKGPIT AVSFAPDGRY LATYSNADSH ICFWQMNTSL LGSIGMLNSA PQLRCIKTYQ
VPPVQPASPG SQNALKLARL IWTSNRNVIL MAHDGKEHRF MV
//
