ID   W5L917_ASTMX            Unreviewed;       777 AA.
AC   W5L917;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 55.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000016329.2, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000016329.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR   AlphaFoldDB; W5L917; -.
DR   STRING; 7994.ENSAMXP00000016329; -.
DR   Ensembl; ENSAMXT00000016329.2; ENSAMXP00000016329.2; ENSAMXG00000015875.2.
DR   eggNOG; KOG0922; Eukaryota.
DR   GeneTree; ENSGT00940000156747; -.
DR   HOGENOM; CLU_001832_5_11_1; -.
DR   InParanoid; W5L917; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000015875; Expressed in embryo and 13 other cell types or tissues.
DR   GO; GO:0006356; P:regulation of transcription by RNA polymerase I; IEA:Ensembl.
DR   CDD; cd17978; DEXHc_DHX33; 1.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF118; ATP-DEPENDENT RNA HELICASE DHX33; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022806};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT   DOMAIN          154..322
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          347..520
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   777 AA;  87138 MW;  0EB098978BE8AFD1 CRC64;
     MIFFLTVTVC NAKCMLSFFH SFIKLDTRTH AHARSSYVNS ARRQSVSHVG GASCSAEVNI
     CSQFSTSITD PFLTPQAPDR APPHRGPVPL PRRFLQIMPH DPDPPPAKKF KPGSPFSRLE
     KKPGMLLPRK GAAPLLLDSQ RKQLPIYQAR SQLLSQLRQL HNAVLIGETG SGKTTQIPQY
     LYEAGIGRQG LIGVTQPRRV AAISLAGRVA QEKNCSLGKL VGYTVRFEDV TSSETKIKFM
     TDGMLLREAI GDPLLLRYTV VILDEAHERT IHTDVLFGVV KSAQRKRKEH NKIPLKVLVM
     SATMDVDLFS QYFNKSPVLY LEGRQHPIQI YYTKQPQSDY LQAALVSIFQ IHQEAPSSHD
     ILVFMTGQEE IEALARTCRD IAKHLPDTCG PMTVIPLYAS LPPTQQLRVF QPAPKGCRKV
     ILSTNIAETS ITISGIKYVI DTGMVKAKRY NPDSGLEVLA VQRVSKAQAW QRAGRAGRED
     SGSCYRLYTE EEFDNLISMT VPEIQRCNLA GVVLQLLALG VPDVLNFDFM SKPSPESMRM
     AVEQLDLLGA VERKDDQVIL TPLGKKMAYF PLEPRYAKTI LISPEFSCTE EVLTILSLLS
     VDSVLYNPPA RRDEVLAVRK KFISSEGDHM TLLNIYRAFK KVSGNKEWCR ENFVNSRNMG
     LVAEVRSQLR DICIKLGLKL ESSQSELVNV RRCLARGMFT NAAELQPDGS YVALDTHQPV
     SIHPSSVLFQ AKPAYVVFNE LLHTSRCYMR DLCLVDSDWL QEAAPEYFRR KLRTTRS
//