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Database: UniProt
Entry: W5LD34_ASTMX
LinkDB: W5LD34_ASTMX
Original site: W5LD34_ASTMX 
ID   W5LD34_ASTMX            Unreviewed;       488 AA.
AC   W5LD34;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 52.
DE   SubName: Full=Keratin, type II cytoskeletal 8-like {ECO:0000313|Ensembl:ENSAMXP00000017746.2};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000017746.2, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000017746.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   AlphaFoldDB; W5LD34; -.
DR   Ensembl; ENSAMXT00000017746.2; ENSAMXP00000017746.2; ENSAMXG00000017238.2.
DR   eggNOG; ENOG502QQIF; Eukaryota.
DR   GeneTree; ENSGT00940000161090; -.
DR   HOGENOM; CLU_012560_6_1_1; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000017238; Expressed in embryo and 14 other cell types or tissues.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45616:SF21; KERATIN, TYPE II CYTOSKELETAL 7; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR   SUPFAM; SSF46579; Prefoldin; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT   DOMAIN          120..431
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          124..263
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          329..409
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   488 AA;  53313 MW;  6F8147E0739FBFC4 CRC64;
     MSVRNVSYSI GGSSGSVRKS YSSHSAYGAP GGSSRISSVR RSGVGAGPGF SGGATYSFSS
     SSIGGGYGGG LGSSIGGGIG GGYGGGFVPA PITAVTVNQS LLAPLNLEID PTIQAVRTQE
     KEQIKTLNNR FASFIDKVRF LEQQNKMLET KWSLLQEQTT TRSNIDAMFE AYIANLRRQL
     DGLGNEKMKL EGELKNMQGL VEDFKRKYED EINKRAAAEN EFVLLKKDVD AAYMNKIELE
     AKVDALQDEI NFLRAVYEAE LRELQSQIKD TSVIVEMDNS RNLDMDSIVA EVRAQYEDIA
     NRSRAEAETW YKQKFEEMQT SAGQYGDDLR STKAEIAELN RMIARLQNEI ESVKGQRANL
     EAQIAEAEER GELAVKDAKL RIKDLEDALQ RAKQDMARQV REYQELMNVK LALDIEIATY
     RKLLEGEENR YLDLSNFNHS FSSASSGFGY GGGIGGGIGG GIGGGMGYGG GSTITKSSVT
     SVNRSRHF
//
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