ID W5LD34_ASTMX Unreviewed; 488 AA.
AC W5LD34;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=Keratin, type II cytoskeletal 8-like {ECO:0000313|Ensembl:ENSAMXP00000017746.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000017746.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000017746.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; W5LD34; -.
DR Ensembl; ENSAMXT00000017746.2; ENSAMXP00000017746.2; ENSAMXG00000017238.2.
DR eggNOG; ENOG502QQIF; Eukaryota.
DR GeneTree; ENSGT00940000161090; -.
DR HOGENOM; CLU_012560_6_1_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000017238; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF21; KERATIN, TYPE II CYTOSKELETAL 7; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR SUPFAM; SSF46579; Prefoldin; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 120..431
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 124..263
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 329..409
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 488 AA; 53313 MW; 6F8147E0739FBFC4 CRC64;
MSVRNVSYSI GGSSGSVRKS YSSHSAYGAP GGSSRISSVR RSGVGAGPGF SGGATYSFSS
SSIGGGYGGG LGSSIGGGIG GGYGGGFVPA PITAVTVNQS LLAPLNLEID PTIQAVRTQE
KEQIKTLNNR FASFIDKVRF LEQQNKMLET KWSLLQEQTT TRSNIDAMFE AYIANLRRQL
DGLGNEKMKL EGELKNMQGL VEDFKRKYED EINKRAAAEN EFVLLKKDVD AAYMNKIELE
AKVDALQDEI NFLRAVYEAE LRELQSQIKD TSVIVEMDNS RNLDMDSIVA EVRAQYEDIA
NRSRAEAETW YKQKFEEMQT SAGQYGDDLR STKAEIAELN RMIARLQNEI ESVKGQRANL
EAQIAEAEER GELAVKDAKL RIKDLEDALQ RAKQDMARQV REYQELMNVK LALDIEIATY
RKLLEGEENR YLDLSNFNHS FSSASSGFGY GGGIGGGIGG GIGGGMGYGG GSTITKSSVT
SVNRSRHF
//