ID   W5LDA8_ASTMX            Unreviewed;       916 AA.
AC   W5LDA8;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 49.
DE   SubName: Full=Tubulin tyrosine ligase like 7 {ECO:0000313|Ensembl:ENSAMXP00000017820.2};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000017820.2, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000017820.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; W5LDA8; -.
DR   Ensembl; ENSAMXT00000017820.2; ENSAMXP00000017820.2; ENSAMXG00000017317.2.
DR   eggNOG; KOG2158; Eukaryota.
DR   GeneTree; ENSGT00940000159078; -.
DR   HOGENOM; CLU_010131_7_1_1; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000017317; Expressed in brain and 6 other cell types or tissues.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   InterPro; IPR004344; TTL/TTLL_fam.
DR   PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR   PANTHER; PTHR12241:SF147; TUBULIN POLYGLUTAMYLASE TTLL7; 1.
DR   Pfam; PF03133; TTL; 1.
DR   SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR   PROSITE; PS51221; TTL; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          516..621
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          657..699
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          375..447
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        571..599
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        605..621
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   916 AA;  104066 MW;  586805AC3978DBE1 CRC64;
     MPSLPNDGED QRTSPENVPP ALSNQNGVKR KVRTKKKKGV ITANVAGTKY EIVRIAIREI
     DFHKTRDEDE TANLIWNDSA VQHEKIAELR NYQRINHFPG MGEICRKDCL ARNMAKMIKI
     QPQEYSFSPK TWIFPAEYTQ FQNYVKELRR KRKQKTFIVK PANGAMGHGI SLIRNCEKLP
     AQDHFIVQEY LDKPFLMEGY KFDLRIYILV TSCDPLRIFL YNDGLVRMGT EKYHTPNDSN
     LSQLYMHLTN YSVNKHNENF ERDETVDKGS KRSIGWFTEF LRTNDYDVAK FWGDVSELVV
     KTLIVAEPHV LHAYRMCRPG QPPGSDSVCF EVLGFDIILD RKLKPWLLEI NRAPSFGTDQ
     KIDFDVKKGV LLNALKLLNV RASDKRRNLA QQKAEAQRRL YGQGTMKKLS AGSSEWEKQR
     LTLERRKEEL KERLAQVRKQ ISREEHEKRH LGNYRRIYPP DDKLLLEKYE GLLSAAFQTF
     LAGRAASLQK EMNNPLKRMK EEDILDLLEQ CELDDEKLMG KTSRQRGPKA LSSMPESAQV
     PRRQRDYEDT SGSCAGSSTS GSDADEEEES ANDLQEKKVS LEVGENKQKS SERSSRVHWK
     PSPKPVRSSS ASSPALSSLI RRSVSCPRSI SSLTAQSPTN EGRSPVLKSS ANIVMAQAAA
     SSPPTPTARP HTALRSHSLS RNSSAHRVPH SSSLGTIHSN MGESLLNVRT KEQEAELTRQ
     TLAALGEMRI RFPGKSEEEA EAVLNEILNN WKYHKPKVAS YWLVKLDATK QRKVLDIVRT
     NVRSVLQRIW REPDVDSLRL YRLFSRVFNR LLWSHGQGLW NCFCSSGRSS WESIFSKSSE
     VVTTQELQCC QRLVQLCRDC LLVVYKFVSD SHGSLTGLSP EWDDTSSPLA AGPVSSRGST
     PSSSTLSLLE AGICCQ
//