ID W5LE21_ASTMX Unreviewed; 422 AA.
AC W5LE21;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=PBX homeobox 4 {ECO:0000313|Ensembl:ENSAMXP00000018083.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000018083.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000018083.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/PBX homeobox family.
CC {ECO:0000256|ARBA:ARBA00007601}.
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DR RefSeq; XP_007229115.1; XM_007229053.2.
DR AlphaFoldDB; W5LE21; -.
DR Ensembl; ENSAMXT00000018083.2; ENSAMXP00000018083.2; ENSAMXG00000017567.2.
DR GeneID; 103036062; -.
DR CTD; 80714; -.
DR eggNOG; KOG0774; Eukaryota.
DR GeneTree; ENSGT00940000165175; -.
DR HOGENOM; CLU_041153_1_0_1; -.
DR OrthoDB; 3684468at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000017567; Expressed in camera-type eye and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR005542; PBX_PBC_dom.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR PANTHER; PTHR11850:SF50; PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 2; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF03792; PBC; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51978; PBC; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 35..229
FT /note="PBC"
FT /evidence="ECO:0000259|PROSITE:PS51978"
FT DOMAIN 228..291
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 230..292
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 317..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 422 AA; 46142 MW; 146070047D991185 CRC64;
MDDQTRMLGL AGLGALSQAD VGDPDAARKQ QALGQPQQDI GDILQQIMAI TDESLDEAQA
RKHALNCHRM KPALFSVLCE IKEKTVLSIR GVQEEDPPDP QIMRLDNMLL AEGVSGPEKG
GGSAAAAAAA AAAGGSPNDG SIEHSDYRAK LAQIRQIYHS ELEKYEQACS EFTNHVMNLL
REQSRTRPIS PKEIERMVAI IHRKFSSIQM QLKQSTCEAV MILRSRFLDA RRKRRNFNKQ
ATEVLNEYFY SHLSNPYPSE EAKEELAKKC GITVSQVSNW FGNKRIRYKK NIGKFQEEAN
LYAVKTAVDA ANVSAQASQA NSPATPNSGS SGSYGLSRTG DSYLSLRSLN GEGLNIAPSL
QQQVDTLHRA THLTGGYEEL SGSALYTPHH LDANSSWQDN PNPSSITPPP GHPSSVHSDT
ST
//
