ID W5LF85_ASTMX Unreviewed; 654 AA.
AC W5LF85;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Histidine ammonia-lyase {ECO:0000256|ARBA:ARBA00017271, ECO:0000256|RuleBase:RU004479};
DE EC=4.3.1.3 {ECO:0000256|ARBA:ARBA00012994, ECO:0000256|RuleBase:RU004479};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000018497.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000018497.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-histidine = NH4(+) + trans-urocanate; Xref=Rhea:RHEA:21232,
CC ChEBI:CHEBI:17771, ChEBI:CHEBI:28938, ChEBI:CHEBI:57595; EC=4.3.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00000171,
CC ECO:0000256|RuleBase:RU004479};
CC -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.
CC {ECO:0000256|ARBA:ARBA00005113, ECO:0000256|RuleBase:RU004479}.
CC -!- SIMILARITY: Belongs to the PAL/histidase family.
CC {ECO:0000256|ARBA:ARBA00007238, ECO:0000256|RuleBase:RU003954}.
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DR RefSeq; XP_007235228.1; XM_007235166.2.
DR AlphaFoldDB; W5LF85; -.
DR STRING; 7994.ENSAMXP00000018497; -.
DR Ensembl; ENSAMXT00000018497.2; ENSAMXP00000018497.2; ENSAMXG00000017914.2.
DR GeneID; 103041200; -.
DR KEGG; amex:103041200; -.
DR CTD; 3034; -.
DR eggNOG; KOG0222; Eukaryota.
DR GeneTree; ENSGT00390000009047; -.
DR HOGENOM; CLU_014801_4_0_1; -.
DR InParanoid; W5LF85; -.
DR OrthoDB; 1030318at2759; -.
DR UniPathway; UPA00379; UER00549.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000017914; Expressed in head kidney and 7 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004397; F:histidine ammonia-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0060218; P:hematopoietic stem cell differentiation; IEA:Ensembl.
DR GO; GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
DR GO; GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway.
DR CDD; cd00332; PAL-HAL; 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR InterPro; IPR001106; Aromatic_Lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR005921; HutH.
DR InterPro; IPR008948; L-Aspartase-like.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR022313; Phe/His_NH3-lyase_AS.
DR NCBIfam; TIGR01225; hutH; 1.
DR PANTHER; PTHR10362; HISTIDINE AMMONIA-LYASE; 1.
DR PANTHER; PTHR10362:SF7; HISTIDINE AMMONIA-LYASE; 1.
DR Pfam; PF00221; Lyase_aromatic; 1.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00488; PAL_HISTIDASE; 1.
PE 3: Inferred from homology;
KW Histidine metabolism {ECO:0000256|ARBA:ARBA00022808,
KW ECO:0000256|RuleBase:RU004479};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU003954};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 5..79
FT /note="Par3/HAL N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12053"
FT REGION 629..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 654 AA; 72364 MW; 4E6E79A195BF7B58 CRC64;
MPRFTVHVRD EWLTVPCKDT SYTINWLGVE ALKRYVKNKP DNGGIPQAKE VRFAARRCQG
QGLLDADDII EDVLEDNDFV ELEIEGDTMS SDFIPSQPGM SYLTRPYREP SEYIFLDGSS
LSSTDLVNLG RCRYKIKLTP EAEKKVEQSR ELLDTIVKEK KVVYGITTGF GKFARTVIPI
SKLKELQENL IRSHSAGLGR PLSPERTRML LALRINVLAK GYSGISLETL HNMIQAFNAS
CLSYVPEKGT VGASGDLAPL AHLALGLMGE GKMWSPKSGW ADAKYVLEAH GLKPVSLKPK
EGLALINGTQ MITSLGAEAV ERAESIAMQA DVIAALTLEV LKGTTKAFDS DIHELRPHPG
QKEVALRFRA LLDSDHHPSE IAESHRFCDR VQDAYTMRCC PQVHGVVNDT IAFVRNIINT
EINSATDNPM VFSERGETIS GGNFHGEYPA KALDYLAIGV HELASISERR IERLCNPSLS
ELPAFLVNEG GLNSGFMIAH CTAAALVSEN KVLCHPSSVD SLSTSAATED HVSMGGWAAR
KALRVIEHVE QVLAIELLAA CQGIEFLRPV RTTTPLEKVY DLVRSVVKPW IKDRFMSADI
EAVHRLLVDQ KVWNVAKPYI EKYCTELLPE SRPSSPTAFS LDPPTSPRKR VRHE
//
