ID W5LFP1_ASTMX Unreviewed; 1064 AA.
AC W5LFP1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Membrane associated guanylate kinase, WW and PDZ domain containing 2a {ECO:0000313|Ensembl:ENSAMXP00000018653.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000018653.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000018653.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5LFP1; -.
DR STRING; 7994.ENSAMXP00000018653; -.
DR Ensembl; ENSAMXT00000018653.2; ENSAMXP00000018653.2; ENSAMXG00000018069.2.
DR eggNOG; KOG3209; Eukaryota.
DR GeneTree; ENSGT00940000155057; -.
DR HOGENOM; CLU_004562_1_0_1; -.
DR InParanoid; W5LFP1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000018069; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0039021; P:pronephric glomerulus development; IEA:Ensembl.
DR CDD; cd00992; PDZ_signaling; 5.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.30.42.10; -; 5.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR10316; MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR10316:SF27; MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF16663; MAGI_u1; 1.
DR Pfam; PF00595; PDZ; 5.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00228; PDZ; 5.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 5.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50106; PDZ; 5.
DR PROSITE; PS01159; WW_DOMAIN_1; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 144..177
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 190..223
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 261..330
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 431..494
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 580..662
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 716..806
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 928..1010
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..874
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1064 AA; 116521 MW; 2708C93BF97820EC CRC64;
MELERSGALL ESGTYEDNYY GTPKPPAEPS ALLLNFPGSA PNADGKRRRN KSVSNMEKAG
IDPPEEEEEE KPVVNGNGIT VTPDSSEQED KSTDASGDLL PAPPAETLLD GPKEENEAPT
TSPPKSPAKV LENAEEKVSE EELGPLPDNW EMAYTEKGEV YFIDHNTKTT SWLDPRLAKK
AKPPEECNEH ELPYGWEKID DPVYGSYYVD HINRRTQFEN PVLEAKRRLQ HPQMPLPLPG
VYREKPLFTR DPTQLKGSFL STALQKSTMG FGFTIIGGDE PDEFLQVKSV IPDGPAAQDA
KMATGDVIVY INEMCVLGTT HADVVKLFQS VPIGQSVTLV LCRGYLLPYD PEDAAASIIS
PLGLMDRPLL VNGRSSYDNY MEYISRTARF MDPMQPGLGP PHQGDTHLDA GPHEDSVSMA
SSGATGGELI TVTMVKGAEG FGFTIADSTG GQRVKQILEA QGCPGLCEGD LIVEVNQQPA
LTLSHTQVVE LLKECPVGSE AKMVVQRGHF SPWKSPTQVL DHWDPQSSLT APALPLSAPY
LHWPSAAEPP QGFDLSKPDP YDLYAKSRAM YESRQFQEVE VNLRREKSGF GFRILGGEEA
GQPILIGAII ENSPADKDGR LRPGDELLSV DGIPVAGKPH RYVIDLMHGA ARNGQVKMTI
RRRAQNTGDQ CPQNGRSPGS ISTQHSSPRS DLNSGTFSNN SAPTEMAANQ SLQASDVIIQ
RKESEGFGFV IISSLNRPET AAAAAVPHKI GRIIEGSPAD RCGKLKVGDR ILAVNNQSIV
SMAHADIVKL IKDAGLSVTL RIITQEEANS TPSAGSSEKQ SPLAQPSPMT QSSQAPPTQS
NSIPLTTTAP QPNLHIHYRS EVKARQDVKP DIRQPPFTDY RQPPVDYRHP PVADYRHPPL
LDYRQLPTDP RSFALPDYRQ QQDFDFFTVE LDKSVKGFGF SIRGGREYKM DLFVLRLAED
GPAIRNGRMR VGDQIIEING ETTREMTHAR AIELIKSGGR RVRLLLKRGT GQVPEYGMVP
SSLSMCMKSD KHGSPYFFLM GQSKDTVSPP PGMLGLQPPQ ACRK
//