ID W5LGE5_ASTMX Unreviewed; 724 AA.
AC W5LGE5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Junction plakoglobin {ECO:0000256|ARBA:ARBA00013753};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000018907.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000018907.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, desmosome
CC {ECO:0000256|ARBA:ARBA00004568}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the beta-catenin family.
CC {ECO:0000256|ARBA:ARBA00005462}.
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DR AlphaFoldDB; W5LGE5; -.
DR STRING; 7994.ENSAMXP00000018907; -.
DR Ensembl; ENSAMXT00000018907.2; ENSAMXP00000018907.2; ENSAMXG00000018337.2.
DR eggNOG; KOG4203; Eukaryota.
DR GeneTree; ENSGT00940000156395; -.
DR HOGENOM; CLU_008757_1_1_1; -.
DR InParanoid; W5LGE5; -.
DR OrthoDB; 50711at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000018337; Expressed in zone of skin and 14 other cell types or tissues.
DR GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045296; F:cadherin binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd21725; CTNNAbd_CTNNG; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR013284; Beta-catenin.
DR PANTHER; PTHR45976; ARMADILLO SEGMENT POLARITY PROTEIN; 1.
DR PANTHER; PTHR45976:SF3; JUNCTION PLAKOGLOBIN; 1.
DR Pfam; PF00514; Arm; 4.
DR PRINTS; PR01869; BCATNINFAMLY.
DR SMART; SM00185; ARM; 11.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 9.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT REPEAT 131..171
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 173..216
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 215..257
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 257..299
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 299..342
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 380..422
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 422..464
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 469..512
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 572..614
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 724 AA; 79431 MW; 0C1DF4B768F9A151 CRC64;
MAMQMGEREG VVKVTEWQKT YYAGDSGIQS GATTVRSDDD GTEYSSKKYT FTTTVTENPA
DLESQYTMTR AQRVRAAMFP ETMEGGTTIL STQLDSSQQT NVQKLAEPSQ MLKTAIIHLI
NYQDDAELAT RAVPELTKLL NDDDQVVVNK AAQIVNQLTK KEASRRALMQ SPQMVAAVVR
AMQNTGDMET ARATASILHN LSHQREGLLS IFKSGGIPAL VRMLSSPMES VLFYAITTLH
NLLLHQEGAK MAVRLADGLQ RMVPLLKKSN HKFLAITTDC LQLLSYGNQE SKLIILANGG
PEGLVQIMRN YNYEKLLWTT SRVLKVLSVC PSNKPAIVEA GGMQALGKHV TGSSQRLSQN
CLWTLRNLSD AATKQDGLDG LLQVLIGLLS TDDVNMLACV TGILSNLTCN NARNKTYVTQ
NNGVEALIHA LLRAGEKEDV AEPATCALRH LTSRHPEAEL AQNAVRTHYG IPAIVKLLNK
PYYWPVVKAV VGLIRNLALC PANQAPLRDA DAIPKLVNLL INAHQDAQKH GSASQQTYQD
GVRMEEIVEG CTGALHIMAR DPMSRGVIAD MNTIPLFVQL LYSPVDNIKR VAAGVLCELA
LDKQSAVVID NEGACAPLME LLHSSNEGIA TYAAAVLFRI SEDKNADYKK RVSVELTHSL
FKHDPAAWDM AHSNAMMDPG YAPEDLDPRF AMPAYGYDPM QQDLDMADDY PQGFDSMQRP
YDAC
//
