ID W5LHZ1_ASTMX Unreviewed; 379 AA.
AC W5LHZ1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Reticulon 4 interacting protein 1 {ECO:0000313|Ensembl:ENSAMXP00000019453.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000019453.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000019453.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. Quinone oxidoreductase subfamily.
CC {ECO:0000256|ARBA:ARBA00010371}.
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DR AlphaFoldDB; W5LHZ1; -.
DR Ensembl; ENSAMXT00000019453.2; ENSAMXP00000019453.2; ENSAMXG00000018893.2.
DR eggNOG; KOG1198; Eukaryota.
DR GeneTree; ENSGT00880000138028; -.
DR HOGENOM; CLU_026673_3_3_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000018893; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd08248; RTN4I1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR037397; RTN4I1.
DR PANTHER; PTHR11695; ALCOHOL DEHYDROGENASE RELATED; 1.
DR PANTHER; PTHR11695:SF294; RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 52..371
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 379 AA; 41050 MW; 7CB139DD7B64A04D CRC64;
MHTAVRRVAC SRWLSLCELS WSGWRAADSG RTLSTSARRS TVMPAWVIDK YGSDNSVFRF
TQNASFPIIH YPNEVIVKVH AAGLNPIDIN MRGGYGAATL AMKRDPLSIK KAGSEFPLIL
GRDLSGEIME CGLDVSYFKP GDEVSHKPKS LSHVDAASIP YVAATAWSAL VNTGGLNKDN
CAKKRILILG GSGGVGTFAT QMIKSWGGHV TVTCSQNAEQ LVRSVGADDV VDYTSGPVET
KLQALEKFDL ILDNIGGETE SWALGLLKPW CGAKYVTLVT PFLRNTDQLG IADGMMQTGV
TIATKAIKHL TKGVHYRWGF FAPSGPALDD ISEMVDAGKI RAVVEETFSF AQVPQAFEKL
EKGHARGKTV VTVTREQKE
//
