ID W5LKC6_ASTMX Unreviewed; 2396 AA.
AC W5LKC6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Chondroitin sulfate proteoglycan 4-like {ECO:0000313|Ensembl:ENSAMXP00000020288.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000020288.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000020288.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR STRING; 7994.ENSAMXP00000020288; -.
DR Ensembl; ENSAMXT00000020288.2; ENSAMXP00000020288.2; ENSAMXG00000019699.2.
DR eggNOG; KOG3597; Eukaryota.
DR GeneTree; ENSGT00940000154091; -.
DR HOGENOM; CLU_000473_1_0_1; -.
DR InParanoid; W5LKC6; -.
DR OrthoDB; 4072625at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000019699; Expressed in muscle tissue and 9 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR45739:SF8; TNFR-CYS DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF16184; Cadherin_3; 11.
DR Pfam; PF02210; Laminin_G_2; 2.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR PROSITE; PS51854; CSPG; 11.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT DOMAIN 20..193
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 203..382
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REPEAT 428..523
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 554..647
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 897..991
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1025..1117
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1133..1223
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1245..1342
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1360..1451
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1475..1565
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1582..1681
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1706..1805
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1839..1931
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REGION 2221..2263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2304..2326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2221..2242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2396 AA; 267324 MW; 21A4E61A6F0A0421 CRC64;
MDVSVFLLEL LALCVGAVRG ASFYGDGFVQ LKAEESSRHN TLHVRFRTSS QRGVLFLAAG
QSDYLLLELT SGRLQAKLDL GSGERILHSD RGNPLNDLAW HTVDLAHDRY NVSLTVDKHF
QISERLPAPQ QELNIKDGLY VGGTGGLDKV YLPSDLTGFR GCLDEVLFNE HNLLSSLRPY
SGLKNVYEVS LGCSPQFFAN EEDPISFFSS RAYVSLPPWS AQQEWTLECS LHTSAQEGII
MYNSARQGDF VSVEIQEGLL VAAVGRDGIK TELRSLTFIN DKRWHSVKLY FTSKSLQLTI
DGENVKSIIS SRSKTLQLKG YLFLGGVDDS TRSEVRKVGL SSVAGKRIKG GSFKGCFKDI
KVNGVPTGLP NAVVTKDISV GCEPEKEPPE IATTLSPTTV PQTLVGSFTE LPPLDVSTLA
KGLVKKYGQN FLQLRNLVVP EGGRASLDSK HIKVNLDFKK LGIRQSQIMF RIEEQPVHGQ
LRFDVDPEQE ENTFSMLDLW HSRVMYIHGG SEDPRDYFMF SVFSNSRKET PSYLKGHKLY
RFNVTVTPTN DAPELSLPEG NLFILLENSK KKVTTDVLKA KDVDSNLSDL VYYVLGNLNA
DAGFLENEDN PGHAIASFPH SALEDGKINY VHTGVRNSRI VLRVSDGEKV SNTVVLRIMA
IALEHSIVNN TGLEVTQGEM ALIGTTQLAV RTNAVKQVVE IRYDVIEPAR FGELQRLHSS
GEWKFTNSFS QRVLEKDRLR YLSTFEGVQS GNVTDRFKCK VTIGAAATTE QFEFAIKIKW
VNYTVERNEM IEMDKIRRVA IDSQHLYATA QGVILAEDEL YFRIMTLTEK GMILLNNEKL
QENSTFSQMD ITNLKVEYQL VDRPYKDTSD QFEFQVFSRH AHSARHVFKI SIKADVNSIY
IRNKGLSILE GESKLIIKDD LFAESLVTKE MYYSVTKSPK HGKLARINLS NSTKDYDRLV
SFTSQDILEE RLMYVHDGSE TTQDQFTFIA SISPTQVKTS VIDDEEVGSK EGVFNISIQL
VNDEKPVRVV DKVFHVVRDG QRLLTLDDLC YHDADSNFSD GQLVYTRRGI PMGDLVLVND
TSHKLYQFTQ EDLEQKRVLF IHRGVSSGRF VLFVSDGKHY VSSLLDIIAQ DPYLRIDNNT
GLLVQKGLAK TFSPANLSVV TNLDIREDSE VTFKVKDAPQ HGGLFLKDEK VESFSQLDLK
SGLLSYRHDN SKNLADFFTI TAKAKGLRLD ARVSVKVYLE SHQKPPVILQ NKTLFVEEGK
PVKIQRSKLE VTHEANLPSE IVFTVKVAPA YGYLRGVVDD QYRGTEEKPL MNFTQQDIND
GALQYVQTTP DQVNDSLLLD ASNGVADVSD ITLSVDIIPR FIPVKVSNIT LKEGASKALT
EKTIRVSNQH FTGLHFVYYV SEGPMHGRIE NSRFPGIPTT YFTRKQVEQE FIYYVHDNSE
TLEDHFTVIA NDTELQKYST PRTVYIQIIP TNDEPPVITA NKVLRVWVGS ITEITPEDMN
AEDDDTPPDQ LNYITTQPSN GHLALKSAPT KPIMNFTQAH IDQSQLIFVH SGATAGGFNF
QVNDGVNFAP RQIFSVTARA LVLRLERNGP LKVFPGSLST ISKEDLRAVT NDDKSNTNRT
IRFTVVNPPT LGKLVSVQAD ESLTEISSFT QEMLDKGEVA YEHTVGSVEW VSLDKITFTV
SSPPASLDAQ TIDIEISYEN AGPERSSRLL KNTGAVVTEG DKVAIDKTML DSSNLLTKEP
EPRRNSYDVW YQVKSFPLHG IIVVGERNLT KEKPYFSQFI LNKYGITYHH DNSETTNDRF
VFDAFLNLKS KPAQRPLDDS EVVEEAFNIT VIPVNDQPPV LKTKTPSLKV VQGDSVAIAS
SNLNVVDLDN PPEEILYSVI SKPSNGFLAL VESLNVSVDS FSQKQINNGE VFFVQDGTPA
SGVFYFSVTD GLHRPVYKLF NLEVLEISIS LVNHTEVMLE QGRTSVDLTQ VHLAAVTNGK
NTTVHYKITV PPRHGKLLLD NEEADAFNQE DLQAHRLSYH MIDLMSSHDS FEFMVFTSEA
NLTDQIVNIT VKPLVRYAEN VGIPNGIRFK LKAAFLNASE LASISDSDPQ FEILSPPRYG
KILRKGNKAE QVRTFTFSEL QQGRLAIEVK ANLTEVQEVN DSFRFVLKAQ NLQPAIGEFP
FKIVPYDPSL MMTTTTTAII PAYTTTTLFP SQTTAISSAL LSISPTIQPT QRLTKPVTKF
KGRNRWGNSN TRSDSQGTTT IVKPDRGPEI TPGKNTPLRV ESAPQGSSSN AALIILPLLA
LVLLIIVVVL VLLLRRKQQK KQKPCIKSAS IPMSSSEGRS YQGPHSERSA TVPLVTVTPL
NPSNPGSPAL MRLQTSSGNS AYGQSMALCS FGDQDLEPSQ FCRTTNPTLQ HNQYWV
//
