ID W5LLE9_ASTMX Unreviewed; 881 AA.
AC W5LLE9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Olfactory receptor C family, v2 {ECO:0000313|Ensembl:ENSAMXP00000020661.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000020661.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000020661.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; W5LLE9; -.
DR STRING; 7994.ENSAMXP00000020661; -.
DR Ensembl; ENSAMXT00000020661.2; ENSAMXP00000020661.2; ENSAMXG00000020066.2.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT01100000263565; -.
DR HOGENOM; CLU_005389_5_1_1; -.
DR InParanoid; W5LLE9; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000020066; Expressed in olfactory epithelium and 2 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR CDD; cd06364; PBP1_CaSR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF504; EXTRACELLULAR CALCIUM-SENSING RECEPTOR ISOFORM X2-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 615..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 653..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 685..709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 729..748
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..797
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 809..829
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 841..864
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 615..879
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 881 AA; 97379 MW; F2330454872AD4E0 CRC64;
METPDAASPT MTGEGCLRTS AQLDPCPVSG CPFTRTRDPF TDKATSAPFK CSAQGDFDQP
AFMADGDITI GGIFPLHYRV ELPTTDYTNK PSAAQCQGFD SRAFRWALAM RLAIDEINNN
TDLLPNHTLG YRIFDSCATP VTAQRAVLAV LNDQESAQSS TCSGGGPLLG IIGESGSSQS
IVVSRTMETF KIPMISYFST CSCLSDRKQF PTFFRVVPSD DYQVKAVAQL LRRFGWTWIG
VVTEDHDYGR FALQGLKREI ENTDICLAYH EMIPKDFRRE RVLEILNVMR KSTARVVVVF
SGEGEFYPFL SEFMHQNITG IQWIASEAWV TASILAETYP FLAGTIGFAV RQGYVPGLKE
YLTTVNPQRY PSNPLVQELW GALYGCSAFP SSTGTQLPLC TGQETLSNQH SAYMNTSSPR
VTYNVYKAVH AIAYSLHNLF QCVPGNGPFE NLSCPDISNI HPWQLQHYLQ EVSFSVSGEK
INFDARGDSI PSYDLINWQR HSNGDIEFVK VGLYDGARDA GRELVIQDQA IVWPGNQSKA
PLSVCSDSCT PGFRKATRNG EPLCCFDCVP CDSGKISNQT DSIDCMACPE EFWSNTNGTA
CIPKIIEFLS HRDTMGIVLM VTAIAGSCLT IAVLAIFLHH RGTPIVRINN SELSFFILLS
LTLCFLCALI FIGEPTSWSC MLRHTAFSIT FSLCISCILG KTLVVLAAFT ATRPGNNVMK
WLGPVQQRII IFSCTLVQMI ICTAWLIASP PFPYRNTQYQ HSKIILDCSV GSDLAFWCVL
GYIGLLACVC FILAFLARKL PGNFNEAKYI TFSMLIFCAV WLAFVPAYVS SPGKFTTAVE
IFAILASSFG LLFCLFAPKC YIILLKPEKN TKQHLMGKAV K
//
