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Database: UniProt
Entry: W5LMA3_ASTMX
LinkDB: W5LMA3_ASTMX
Original site: W5LMA3_ASTMX 
ID   W5LMA3_ASTMX            Unreviewed;      2673 AA.
AC   W5LMA3;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   22-NOV-2017, entry version 19.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor, type 2 {ECO:0000313|Ensembl:ENSAMXP00000020965};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000020965, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000020965, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000020965};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000020965}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMXP00000020965}.
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DR   EMBL; APWO01090579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01090580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01090581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007250632.1; XM_007250570.2.
DR   Ensembl; ENSAMXT00000020965; ENSAMXP00000020965; ENSAMXG00000020360.
DR   GeneID; 103025600; -.
DR   CTD; 3709; -.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; RIYNCTW; -.
DR   OrthoDB; EOG091G00T2; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   Gene3D; 1.25.10.30; -; 3.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt-bd.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2197   2230       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2242   2261       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2268   2294       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2324   2354       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2375   2397       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2495   2518       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    223       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    287       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      294    344       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      377    433       MIR. {ECO:0000259|PROSITE:PS50919}.
SQ   SEQUENCE   2673 AA;  306037 MW;  A6B1C5853C121DF7 CRC64;
     MSEHRSSFLH IGDIVSLYAE GTVNGFISTL GLVDDRCVVQ PEAGDLANPP KKFRDCLFKV
     CPMNRYSAQK QFWKAKQGKQ GGNTEGDLFK KLQHAAELEQ KQNETENKKL LGEVVKYSQV
     IQLLHIKSNK FLTVNKRLPA LLEKNAMRVS LDPSGNEGSW FYIQPFWKLR SEGDNVVVGD
     KVVLMPVNAG QPLHASNIEL LDNPGCNEVN AVNCNTSWKV TLFMKFSDYK DDILKGGDVV
     RLFHAEQEKF LTCDDYKDQQ HIFLRTTLRQ SATSATSSKA LWEVEVVHYD PCRGGAGQWN
     SLFRFKHLAT GKYLAAEVNP AYRDESLETK NETESDAVYS KKKRPVEKIT YILVSVPHGN
     DIASLFELDA TTLQRADCLV PRNSYVRLRN LCTNTWVTST NNSIDHEEER PVMLKIGTCP
     TKEDKEAFAI VSVPLSEVRD LDFANDANKV LEAFVRKLEK NTFAQNDRRF VIKLLEDLVF
     FVCEVPNNGQ DVLSVVISNP NRERQKLMRE QNILAQIFGI LKAPFADRED GPILKLEDLG
     DQRYAPFKYM LQLCYRILRH SQQDYRKNQE YIAKKFSIMQ SQIGYEILAE DTITALLHNN
     RKLLEKHITA REIETFVKLL RRNREPRFLD YLSDLCVSNK TAIPVTQELI CKFMLNPTNA
     DILIQTKLIP HTENSMDSSL MHEEGDEEEV WLYWIDHNKE PHGKSIRHLA QDSKGNHKLD
     IDIITYYRCQ LNLFAKMCLD RQYLAINQIS TQLPVDLILR CMFDDCLPYN LRASFCRLML
     HMHVDRDPQE AVVPVRYARL WNEIPSKISV KDYEYEFRDT SRADMKRKFA PTMDFVDEYL
     KDVLSQPFPF GDEEKNELTL EVVNLARNLV YFGFYSFSEL LCLTRTLLAI LDIVQHPLTF
     MSKLSKGPDG GNNVLRTIHG VGEMMTQMVL SRGSMLPHSL PDSQPMMGHG KPLCVLDNQD
     VMVMDTKLRI IEILQFILSV RLDYRITYLL SIYKKEFGEQ NVTDNTLSVS DFPPAQSEPN
     VEEIAEKAEI MFTGSGVERD LVALDDEGGR TFLRVLIHLI MQDYPPLVSG SLQLIFKHFS
     QRAEVLQAFK QVQLLVSEKD VENYKQIKAD LDQLRLTVEK SELWVEKSGS YGNEDMTENQ
     NKDQIMEEAG ILSPVQDGNI KPQIDSNKAN NYIIVKEILH RLNKLCYSVK KSRVQQQRLL
     KNMGAHVVVL DLLQIPYEKG DEKMLEIMTL AHTFLQNFCN DNPQNQILLH KHLNLFLTPG
     ILEARTMHYI FQNNYHLCNE ISDRVVHHFV HCIETHGRSI HYLRFLQTIV KSDGKYVKKC
     QDKVMTELVN GGEEVLLFYN DRASFPALLQ LMNSERERHD ENSALSYHIN LVELLAACTE
     GKNVYTEIKC NSLLPLDDIV NVVTHDDCIP EVKIAYVNFV NHCYVDTEVE MKEIYTSNHI
     WKLFESFRVD MDRVCNSTTD RKHADTMMEK YVTETIMAIV KGFFASQFSV NNSNLQTHQP
     IFIQLLQAAF RVYNCSWVSS LQKSNIEACI KTLSDVAKNR NIAIPVDLDS QVNTFSLKSH
     TNMVQRAAKD WRQSARRPRK EPLGAPDYKN IIEKLQGVVS FLKEQFSPRV QAEFSVLVDV
     LHSPELLFPE AARMRCESGA FMTKLIKHTK KLMEKEEKLC IKILQTLREM LDKKETFDDR
     GNALRKTMLT HYFGNQRLHS KALDYGSSGG SSPGAGSPGQ DSEKPGTTVV EIQCLLDSVG
     ASELVIDLIV STKNDRVFEE SIQLGIALLR GGNSQTQNSF HHQLHKQKKS EKFFKVFYDR
     MQLAQKEIRS TVSVNMFEIS CRKREEEGEV SGVRQKKGRD TLHIREEMRG QLKDASCATS
     KAYSMFRKEG DPDLELVGSG SEETEEEVEE VQMSQAITIM EPILRFLQLL CENHNRHLQN
     FLRDQNNKTN YNLVCETLQF LDCICGSTTG GLGLLGLYIN ERNVDLVIQT LETITEYCQG
     PCHENQSCIA KHESNGIDII IALIVNPIEP LGKNRMDLVL KLKNNASKLL LAIMESCHDS
     ENAEQILDKM RPNELVDVIK EAFAQGVEGE VDLEAIGDEI TPKDVGHNIY ILAHQLARHR
     KQLQQSLKPC PDSDTEDSLG YYAKHTAQIE IVRHDRSMEQ IVFPVPNICE YLTEESKVRV
     FTTTERDDQG SKVNHFFQQF DDLYNEMWWQ KKMRNNVALF WVAKHISLWG SISFNLAVLV
     NMAVALFYPF GDDDDEGVLP PLLSVLLWVA VVVSTSLLFI LPRQGGILAF LVTIILRSIY
     TIGLHPTLVL LGAANLLNKI VFLVSFVGNQ GTFTRGYKAV IMDIFFLLHV FYVIVCMLGL
     FVHEFFYSIL LFDLVRREET LLNVMRSVTK NGRSIFLTAV LAIILVYLFS IVGFLFLQSD
     FLMEVDRHPA LVSEKVKAHE VADSMTCERD GCPAPSFSQV EKSDEPEMER VCETLLMCIV
     TVLNHGLRNG GGIADILRKP SKDEPMFAAR VVYDLLFFFI VIIIVLNLIF GVIIDTFADL
     RSEKQRKEEI LKTTCFICGL ERDKFDNKTV SFEEHIKVEH NMWHYLYFLV LVRVKDPTEY
     TGPESYVAQM IKEKNLDWFP RMQAMSLVTS AGESEQNEMR SLQEKLDITV TLVSQLSAQL
     AELKEQMTEQ RKNKQRMGFL GSSQANHHMP PAH
//
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