ID W5LNU4_ASTMX Unreviewed; 1202 AA.
AC W5LNU4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Tight junction protein ZO-2 {ECO:0000313|Ensembl:ENSAMXP00000021506.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000021506.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000021506.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR AlphaFoldDB; W5LNU4; -.
DR Ensembl; ENSAMXT00000021506.2; ENSAMXP00000021506.2; ENSAMXG00000020891.2.
DR eggNOG; KOG3580; Eukaryota.
DR GeneTree; ENSGT00940000158634; -.
DR HOGENOM; CLU_006234_1_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000020891; Expressed in camera-type eye and 13 other cell types or tissues.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd11859; SH3_ZO; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR005417; ZO.
DR InterPro; IPR005419; ZO-2.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR PANTHER; PTHR13865:SF26; TIGHT JUNCTION PROTEIN ZO-2; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01597; ZONOCCLUDNS.
DR PRINTS; PR01599; ZONOCCLUDNS2.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 33..120
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 321..399
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 536..617
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 740..905
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 125..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 722..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 953..1091
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1119..1202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 959..973
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1168..1185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1186..1202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1202 AA; 135799 MW; 43A6B359C57166F8 CRC64;
MPVLEERRLF LSRKRNEYCR NPVMEETVWE QYTVTLQRDS KMGFGIAVSG GRDNPNEESG
EISIVVSDVL QGGPAEGLLF ENDRVIQVNT APMDNVPHSF AVQTLRKCGK VAKITVKRSR
KVPVNMLKRA PSPDDRVFSN TDYNDDYDYD QDRRSVYSRP DHEIVSERGY PDSEYDYDRG
SRGRALDRDF SPDRPYRRDG SRGRLLDRER SPDNRYRSDR TLDRDRSPDR RYRSEHTLDR
DYSPDRSYRG DRGGSPDRRY RSDHTLDRTH SPDQRYRDRE PRRYESRQEE PPKRSGSRDR
LDRSPSPPPP RDPEPLDKPV SVMLLKNRPN DEYGLRLGSQ LFIKEMTSTG LASKDGNLQE
GDIILKINGT VTENLSLSDA GKLIEKSRGK LQLVVQRDRR QILVRMPPMA DSDSELDDIS
EIESYRSYSP QDDRRGHHSD LSSHSSNERL REKPRDEPPN RLAKMGAKPT PFRTAPAPDL
DLPPPPPVEL DEPHIEEPPA PVISAAPKIS IPPKPKAVRK VPLQPSPEDL EIYGPNTVMM
RFQKGESVGL RLAGGNDVGI FIAGVQEDSP AEVEGLRMGD QIMKVNSMDF RGMVREDAVL
YLLEIPKGED VTILAQSKPE VYSDILSSGR GDNFFIRTHF DHEKDAPQGL AFTRGEVFKV
VDTLYDGKLG SWLAIRTDRD NQLLEKGIIP SKSRAEQMAN VQSAQKGGGN DRGDFWRLRG
QRAGKKKDLR KSREDLTANP GTTRFPAYER VVLREAGFRR PVVIFGPIAD AANEKLANDM
PEEFVLAKTE PKDAGSEKSS GVVRLNTIRQ IIEQNKHALL DVTPKAVDTL NYTQWYPIVV
FLNPDSKQGV KTMRNRLVPG SSRSSRKLYE QAVKLRKTCS HLFTATVDLS SAHDAWYGGL
KETIREQQSK AVWVCEGKLD GTEEDLDLHD DRMSYLSAMS ADYLSMDSRL TSDYEDTADE
GGAYTDNELD EPMDEPQVSG TSRSSEPVMP DERPAPVPRM KRAGSREVLR DPSPPPSFVP
EPPKVRSHTR SSDNRSFDSH SSSTVSSDTP VSSKPLPPPV ALKPSFSGRP APAQEPNSNA
EDPASRSFLG KVKAFEQMDH LARAQRMLEL QEAEHARLEI SQKHPDIYAV PIKPKPNQNR
PQPIGSSSNS ESHGSSSKPP YMEGRGPYRS TAEDDEEDYR RQLSDQTRRG YYNPQKYNDT
EL
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