ID W5LNW5_ASTMX Unreviewed; 630 AA.
AC W5LNW5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Pumilio RNA binding family member 3 {ECO:0000313|Ensembl:ENSAMXP00000021527.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000021527.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000021527.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 7994.ENSAMXP00000048142; -.
DR Ensembl; ENSAMXT00000021527.2; ENSAMXP00000021527.2; ENSAMXG00000020911.2.
DR Ensembl; ENSAMXT00000034633.1; ENSAMXP00000048142.1; ENSAMXG00000020911.2.
DR eggNOG; KOG2050; Eukaryota.
DR GeneTree; ENSGT00390000015757; -.
DR HOGENOM; CLU_013994_0_1_1; -.
DR OrthoDB; 5488678at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000020911; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008354; P:germ cell migration; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012959; CPL_dom.
DR InterPro; IPR033133; PUM-HD.
DR InterPro; IPR040059; PUM3.
DR InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR PANTHER; PTHR13389:SF0; PUMILIO HOMOLOG 3; 1.
DR PANTHER; PTHR13389; UNCHARACTERIZED; 1.
DR Pfam; PF08144; CPL; 1.
DR Pfam; PF00806; PUF; 2.
DR SMART; SM00025; Pumilio; 6.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50302; PUM; 1.
DR PROSITE; PS50303; PUM_HD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 121..494
FT /note="PUM-HD"
FT /evidence="ECO:0000259|PROSITE:PS50303"
FT REPEAT 185..221
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REGION 1..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..115
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 630 AA; 71087 MW; 2168CC733A71BA86 CRC64;
MEAKPRKKSF AAKDGKKPAF KGKGKFEGKP PGKRPFKPHN ADKKKPFVKP GGKGGAQKFM
KQKPTDGKFV KKRKLSDGDS TKEEGSEAKK PKWNEFKQKK KELKQNRQQN DRKDSFQTVI
RAKQVWEMIR RKDCDKDKKE KLLKELRELV RGKVKTIAFA HDSTRVLQCF IQFGNDKQRQ
EIFDELKDHM VELSKSKYAR NIVKKFLMYG SKQQVGEVML AFKGKVRQML RHSEASSVVE
YAYNDKAILS QRLMLTEELY GNTFQVCKST VCPTLEKVLE SNPEKLESIA DEMKQILTPM
AQKEAVIKHS LVHKVFLDFF LHAPDKLKSE MIESIRESVV YMAHTHDGAR VTMHCLWHGT
SKDRKVIIKT MKTYIAKFAM GEYAHLVLLA AFDCIDDTKL VKQAVLSELV SSLAEVISNK
HGKKVLLYLL SPRDPAHLLP EIIQVLEKGD GNAHSKKDVS VRRQELLEAI SPPLLTYLCE
NTRSMVMDKA CSVVVSDILG AAVGDLWPAM GAVAELAAED FVAGGVDGQL HMAEHPAGHL
VLKWLIEQDA KMKAAGREER FSRVLLEKVG LDKLKTWVSV NRGAMVLCCL LQSADEGVAE
DVRTALRSII PKLKKIQNSK GVEALLEKLA
//
