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Database: UniProt
Entry: W5LPY5_ASTMX
LinkDB: W5LPY5_ASTMX
Original site: W5LPY5_ASTMX 
ID   W5LPY5_ASTMX            Unreviewed;      1954 AA.
AC   W5LPY5;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   07-JUN-2017, entry version 31.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000022015, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000022015, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000022015};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000022015}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMXP00000022015}.
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DR   EMBL; APWO01022509; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01022510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01022511; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01022512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01022513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01022514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01022515; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007233938.1; XM_007233876.2.
DR   Ensembl; ENSAMXT00000022015; ENSAMXP00000022015; ENSAMXG00000021379.
DR   GeneID; 103037861; -.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; TMLLPRP; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF00612; IQ; 1.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    125    148       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    224    245       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    251    271       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    394    421       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    707    725       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    737    760       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    817    845       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    905    930       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1145   1164       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1185   1201       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1213   1232       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1277   1297       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1384   1407       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1466   1484       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1496   1518       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1530   1549       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1597   1619       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1687   1710       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      128    427       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      505    627       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      707    934       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      944   1140       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1144   1416       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1465   1720       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1724   1787       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED      436    459       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1954 AA;  221975 MW;  4B8F6AF00E3DD555 CRC64;
     MAAMLFPPGP DSLHRFTRES LAGIEQRIAE EQARNARRYQ EDLGDVELPK PRADLEAGKQ
     LPRIFGDIPS GLVGVPLEDI DPFYFQNQRT FIVLNKGKAI FRFSATSALY IFSPFHPIRR
     ASIKILVHSL FSLFIMCTIL TNCCFMAMSE PAPWAKYVEY TFTGIYTFES LIKILARGFC
     IGPFTFLRDP WNWLDFSVIV MAYVTEFVDL GNVSALRTFR VLRALKTISV IPGLKTIVGA
     LIQSVKKLAD VMILTVFCLS VFALIGLQLF MGNLRQKCVR SPAHCINNTV PSIYSNSSFY
     CNNRTWLSVH DFITDEDNFY KVEGAKDALI CGNSSDAGKC PDGFECMKTG RNPNYGYTSF
     DTFGWAFLSL FRLMTQDYWE NLYHQTLRSA GKTYMVFFVV VIFLGSFYLV NLILAVVAMA
     YEEQNQATIA EAWQKEKEFQ LAMEQLKKEQ QAAQKAQETE SVLVPDLSPS ALQDDKEHKG
     RKKSLRPLSE EAENDGAEKT PKLDAIEGVK QTHALLVRTL SSRTRRGSQV SIFNFRPRNK
     DSEADADDEY SVYGDSDSRA GSLVIPWHRR RTSAQSTGSH SSQVFFPSLN INGKLFVAMD
     QNGISGPGPL SPLPLPTCTM EKVKEESGTN SLNELSSMLL PQLPQEGRDR ALSAASYLTD
     AMEELEEAQQ KCHPCWYVFA HKYLVWTCNP GWLKLKEWVK FMVMDPFLDL AITICIVLNT
     LFMALEHYPM TDEFNKMLSV GNLVFTGIFT AEMVLKIIAL DPYYYFQQGW NIFDSFIVCL
     SLMELGLSNV EGLSVLRSFR LLRVFKLAKS WPTLNTLIKI IGNSVGALGN LTLVLAIIVF
     IFAVVGMQLF GKNYELCVCK ISKDCILPRW HMKDFFHSFL IVFRVLCGEW IETMWDCMEV
     AGQPLCILVF MLVMVIGNLV VLNLFLALLL SSFSADNLSA PDEDGEMNNL QIAIARIHRG
     IGWLRRALCD FFNGNFKRRR QKAKEAKAML KLKRLSQQAQ RAEGNGTAGV IARTGDKCAA
     TDDSYMTNPN LTISVPIAPG ESDVEFPEEE DDDDEASESS DEEEEAETKP SDDISLSEGS
     TVDLRKPGEE EDEYSEMAEE DMDPDNCFPE VCVRHFQCCD INTNEGLGRV WWRLRKTCYH
     IVEHSWFETF IIFMILLSSG ALAFEDIYIE QRKVVKIVLE YADKIFTYIF ILEMTLKWIA
     YGFKKYFTNY WCWLDFLIVD VSLVSLVANT LGYSDFAAIK SLRTLRALRP LRALSRFEGM
     RVVVNALIGA IPSIMNVLLV CLIFWLIFSI MGVNLFAGKF GRCLNRTGFV YNASHINNKT
     ECLAMNDTQY YWSKVKVNFD NVGAGYLALL QVATFKGWME IMYAAVDSRA VEEQPVKEVN
     LYMYLYFVIF IIFGSFFTLN LFIGVIIDNF NQQKRKLGGQ DIFMTEEQKK YYNAMKKLGS
     KKPQKPIPRP LNPLQGFFFD LVSKQAFDIM IMLLILLNMV TMMVETDEQS PRMEMILYNI
     NLAFIVIFTT ECIIKLIALR CYFFTVSWNI FDFVVVILSI VGIVLADIIE KYFVSPTLFR
     VIRLARIGRI LRLIRGAKGI RTLLFALMMS LPALFNIGLL LFLVMFIYAI FGMANFAYVK
     KQGGIDDMFN FETFGNSMIC LFQITTSAGW DSLLGPILNN SPEECDPNIP HTGTNARGNC
     GNPSVGITFF VTYIIISFLI VVNMYIAIIL ENFSVATEES TEPLSEDDFE MFYEVWEKFD
     PEATQFIEYA KLSDFADTLS EPLRIAKPNK IKLISMDLPM VSGDKIHCLD ILFAFTKRVL
     GESGEMDALK QQMEEKFMMA NPSKISYEPI TTTLRRKQEE VSAVVIQRAY RRHLVRRQLK
     QASFIYRQIN SDGAAKEDES PPEKEGLIAS LMKENYGPEV EVEVEDLSST SSPPSYDSVT
     RATSELFQAL IPDSRNSDLS KSYPEPDRDR ETFL
//
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