ID W5LQI1_ASTMX Unreviewed; 2754 AA.
AC W5LQI1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Fibrillin 2b {ECO:0000313|Ensembl:ENSAMXP00000022278.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000022278.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000022278.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the fibrillin family.
CC {ECO:0000256|ARBA:ARBA00008972}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 7994.ENSAMXP00000022278; -.
DR Ensembl; ENSAMXT00000022278.2; ENSAMXP00000022278.2; ENSAMXG00000021616.2.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00950000183158; -.
DR HOGENOM; CLU_000233_0_0_1; -.
DR InParanoid; W5LQI1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000021616; Expressed in embryo and 6 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0001527; C:microfibril; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl.
DR GO; GO:0060958; P:endocardial cell development; IEA:Ensembl.
DR GO; GO:0003160; P:endocardium morphogenesis; IEA:Ensembl.
DR GO; GO:0003007; P:heart morphogenesis; IEA:Ensembl.
DR GO; GO:0048570; P:notochord morphogenesis; IEA:Ensembl.
DR GO; GO:0003250; P:regulation of cell proliferation involved in heart valve morphogenesis; IEA:Ensembl.
DR GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 23.
DR Gene3D; 2.10.25.10; Laminin; 45.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 9.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR049388; FBN_EGF_N.
DR InterPro; IPR040872; Fibrillin_U_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24039:SF49; FIBRILLIN 2; 1.
DR PANTHER; PTHR24039; FIBRILLIN-RELATED; 1.
DR Pfam; PF12662; cEGF; 2.
DR Pfam; PF12947; EGF_3; 2.
DR Pfam; PF07645; EGF_CA; 35.
DR Pfam; PF21364; FBN_EGF_st1; 1.
DR Pfam; PF18193; Fibrillin_U_N; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF00683; TB; 9.
DR PIRSF; PIRSF036312; Fibrillin; 3.
DR SMART; SM00181; EGF; 46.
DR SMART; SM00179; EGF_CA; 43.
DR SUPFAM; SSF57196; EGF/Laminin; 11.
DR SUPFAM; SSF57184; Growth factor receptor domain; 11.
DR SUPFAM; SSF57581; TB module/8-cys domain; 9.
DR PROSITE; PS00010; ASX_HYDROXYL; 41.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 26.
DR PROSITE; PS50026; EGF_3; 38.
DR PROSITE; PS01187; EGF_CA; 16.
DR PROSITE; PS51364; TB; 9.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 115..147
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 153..196
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 215..256
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 257..297
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 302..356
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 422..461
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 462..503
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 504..544
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 545..585
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 591..643
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 655..696
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 697..738
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 739..774
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 783..822
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 842..883
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 888..939
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 960..1001
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1002..1044
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1045..1086
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1087..1128
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1170..1211
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1212..1249
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1254..1294
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1295..1333
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1336..1377
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1378..1414
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1419..1459
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1464..1520
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1537..1578
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1579..1616
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1625..1677
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1695..1736
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1737..1775
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1779..1816
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1821..1863
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1864..1901
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1907..1948
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1955..2008
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2024..2065
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2066..2105
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2191..2232
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2237..2290
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2302..2339
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2344..2384
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2385..2421
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2424..2466
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2507..2547
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 119..129
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 137..146
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 426..436
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 743..753
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2754 AA; 297403 MW; 6A12A47A3A810102 CRC64;
IYYSFLLPLF LPFISCFVYF ACFFCYRPNV CGSRFHSYCC PGWKTLPGGN QCIVPICRNT
CGDGFCSRPN MCTCSSGHLA PSCGAASCSV RCMNGGACND DSCVCQKGYT GNHCGQPVCE
SGCQNGGRCI GPNRCACVYG FTGPQCERDY RTGPCFTQVN NQMCQGQLSG IVCTKTLCCA
TIGRAWGHPC EVCPAQPHPC RRGFIPNIRS GACQDVDECQ AIPGLCAGGN CINTVGSYEC
KCPAGHRQSE TNQKCEDIDE CALPGLCDGG ECTNTAGSYV CTCPRGYVSS ADGSRCIDQR
IGTCFSALAN GRCAAELTGQ FSKMQCCCDL GRCWALGHIP EMCPVRGSGE LFAKACDSPQ
SYASSPSPSP YPPELLLLHS TIDVCKHFTN LCLNGRCIPT TASYRCECNM GYRQDMRGEC
IDVDECISNP CVNGDCVNTQ GSYHCKCHEG YQGTATKQAC IDIDECIVNG VMCRNGRCVN
TDGSFQCICN AGFDLSPDGK NCIDHDECAT TNMCLNGMCI NEDGSFKCIC KQGFALAPNG
RYCTDIDECQ TPGICMNGRC INSEGSFHCE CPPGLAIDVD GRVCVDTHMR TTCYGAIKMG
TCSRPFPGAV TKSECCCANP EHGFGQPCQP CPARNSAEFQ AVCSSGIGIT TDGRDINECA
LDPEICQNGM CENLLGSYRC ICNIGYESDS SGKNCVDINE CLVNRLLCDN GLCRNTPGSF
TCSCPKGFVF KADSETCEDI NECESSPCVN GICRNLAGSF TCECSHGSKL DSTNTVCVDS
MKGTCWLNIQ DNRCEVNING ATLKSECCST LGAAWGSPCE RCEVDTACPR GLARMKGLIC
EDINECEVFP GVCSNGVCVN THGSFRCECA EGLTLDEGGR TCVDVRSEHC YMKWDEDECG
EPLPGRYRVD MCCCSVGAAW GLECESCPKP GTPEYRTICP RGPGFANRGD ILTGRPFYKD
VNECKVFKGL CTHGTCRNTI GSFKCRCNNG FALTMEERNC TDIDECAISP DLCGQGTCVN
TPGSFECECF EGYESGFMMM KNCMDIDECE RDPLLCRGGT CLNTEGSYEC ECPRGHQLSP
GGSSCEDVNE CELSDNLCRN GQCVNMVGSY QCSCDTGYQV TPDRQGCVDI DECTIMNGGC
DTHCTNSEGS YECSCSEGYA LMPDLRTCAD IDECEDTPDI CDGGQCTNIP GEYRCLCFDG
FMSTMDMRTC EDVNECDLNP NICLHGDCEN TKGSFICHCQ LGYFVKKGST GCTDVDECEI
GAHNCDMHAA CVNVPGSFKC RCRDGWVGDG IKCVDLDECS TEEHSCNPNA NCVNTPGSYR
CACKEGFNGD GFSCSDMDEC AENVNLCENG QCLNTPGGYR CECEMGFTPT EDTKACQDID
ECNFQNICVF GSCQNLPGMF RCVCDDGYEL DRSGGNCTDV NECADPVNCI NGLCVNMPGS
YLCNCPADFE LNPTGVGCVD TRVGNCFLDT LDRGDGGISC SAEIGVGVTR ASCCCSLGGA
WGNPCELCPP VNSTEYKTLC PGGEGFRPNP ITVILEDIDE CQELPGLCQG GNCVNTFGSF
QCECPAGYYL NEETRICEDI DECTAHIGIC GPGTCYNTLG NYTCVCPPEY MQVNGGNNCM
DMRKSVCYRN FNDTCENELS FNMTKKMCCC AYNVGKAWNK PCEACPTPAT SEYQLLCGNQ
APGFIIDIHT GKPIDIDECR EIPGICANGV CINQIGSFRC ECPMGFSYNN ILLICEDIDE
CNSGDNLCQR NANCINIPGS YRCECSPGFK LSPSGACVDR NECKEKPNVC SHGDCIDMQG
SYRCLCHNGF KATADQTMCM DVDECTTLSG QVCRHGQCIN SLGSFQCLCQ EGYELTPDNK
NCADVNECVT FPGTCSPGTC QNLVGSFRCI CPPGYAVQND QLTCVVYIND CEVEPNICQF
GTCINTPGSF QCICQPGFVL SDNGRRCFGK FTVDIFCFTR FEAGKCSVPK ALNTTKAKCC
CSKMPGEGWG DPCELCPREN EAGFNALCPY GHGTLPGPGD GREDMNECLD NPGICVNGMC
INTDGSFRCE CPFGYNLDYT GVNCVDTDEC SIGNPCGNGT CTNVVGGFEC SCQEGFEPGP
MMTCEDINEC SLNPLLCAFR CVNTFGSYEC MCPAGYVLRD DQRMCRDQDE CTEGLDDCAS
RGMACKNLIG TFMCICPPGM TRRPDGEGCM DLNECRTKPG LCKNGRCVNT VGSYRCECSE
GFEPSATGTE CIDNRQGFCF TEVLQTMCQQ GSTNRNSVTK SECCCNGGRG WGPQCELCPL
PGTVQYKKMC PLGPGYTTDG RDINECEVLP NLCKNGQCIN SVGSFRCHCN VGYTNDFSGT
SCIDLDECSQ SPKPCNFLCK NTEGSYLCSC PRGYILQPDG KTCKDLDECS TKQHNCQFLC
VNTIGGFTCK CPSGFTQHQT ACIDNNECTN QPSVCGSRAS CLNTPGSFNC ECQKGFSLDG
TGVECEDVDE CTGNHRCQHG CQNMLGGFRC GCPQGYVQHY QWNQCVDENE CSGNQVCGSA
SCYNTLGSYK CVCPSGFDFQ AGAGGCQDIN ECSMGSNPCS FGCSNTDGGY LCGCPGGFYR
AGQGHCITGA GFQGQFSSEG DEESALSPET CYECKINGDV GKGGRHRRNA DSVSLASVDT
QTSIPMNLSL ASLQNKEPLL ELLPALEPLE HHVRYVITHG NQGEHFRLLE RRDGKSVLRL
GRKLPPPGSY RLEIASLPLF GPRKLRELED QHDSDYLLGE IGDALRIKLH IHLH
//
