ID W5LRH8_ASTMX Unreviewed; 465 AA.
AC W5LRH8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN Name=CHST2 {ECO:0000313|Ensembl:ENSAMXP00000025521.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000025521.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000025521.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc
CC subfamily. {ECO:0000256|ARBA:ARBA00005530}.
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DR AlphaFoldDB; W5LRH8; -.
DR STRING; 7994.ENSAMXP00000025521; -.
DR Ensembl; ENSAMXT00000025541.2; ENSAMXP00000025521.2; ENSAMXG00000024815.2.
DR eggNOG; ENOG502QTSD; Eukaryota.
DR GeneTree; ENSGT00940000161292; -.
DR HOGENOM; CLU_028381_1_0_1; -.
DR InParanoid; W5LRH8; -.
DR OrthoDB; 3031241at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000024815; Expressed in brain and 14 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:InterPro.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR016469; Carbohydrate_sulfotransferase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10704; CARBOHYDRATE SULFOTRANSFERASE; 1.
DR PANTHER; PTHR10704:SF3; CARBOHYDRATE SULFOTRANSFERASE 2; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR PIRSF; PIRSF005883; Carbohydrate_sulfotransferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transferase {ECO:0000256|RuleBase:RU361155};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT DOMAIN 264..439
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 465 AA; 53243 MW; 83823DAEE72FC6E3 CRC64;
MRGKQFQQQL KQAAPRETDS DYGRRLKTYQ NHTKIIAQPG IVMKVLRKKR MILFIAYFLL
LVLTMLNLAN YRWSKEPQQC SHQTRSTAYQ GRSDIRFLYR PSLAKKRQLV YVLTTWRSGS
SFFGELFNQN PDVFFLYEPM WHIWQKLYPG DAVSLQGAAR DMLSALYRCD LSVFQLYNSP
GGKNFTSLGL FGATLNKVIC SYPLCSAYRK EVVGMVDDKV CKKCPPQSLR MLEEECLKYN
TIVIKGVRIL DVNVLAPLME DPSLDLKVIH LVRDPRAVAN SRIKSRHGLI RENLQVVRSR
DPKLRRIPFV DAGHKMSKKD GADYHSIGAM EVICDRTHRS LRTALNPPAW LKGKYLTVRY
EDLVENPVKV VRNIYRFVNL SVNHDIESFA LNMTNGTNSS SKPFIVSSRN ATQAASAWRT
LLSIQQIKQV EDYCHQAMGV LGYERVRTAS EAKDLGKSLM TASKL
//
