ID W5LTS6_ASTMX Unreviewed; 710 AA.
AC W5LTS6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Leucine rich repeat neuronal 1 {ECO:0000313|Ensembl:ENSAMXP00000026540.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000026540.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000026540.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5LTS6; -.
DR STRING; 7994.ENSAMXP00000026540; -.
DR Ensembl; ENSAMXT00000026561.2; ENSAMXP00000026540.2; ENSAMXG00000025835.2.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000157154; -.
DR HOGENOM; CLU_000288_18_18_1; -.
DR InParanoid; W5LTS6; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000025835; Expressed in brain and 8 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0021628; P:olfactory nerve formation; IEA:Ensembl.
DR GO; GO:0071699; P:olfactory placode morphogenesis; IEA:Ensembl.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24373:SF97; LEUCINE-RICH REPEAT NEURONAL PROTEIN 1; 1.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..710
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017356481"
FT TRANSMEM 625..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 418..511
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 519..611
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 686..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 710 AA; 80219 MW; CFFC24103026DFE3 CRC64;
MLGEANDLLF MTLLVLTLSS AEATDCPHLC VCEIRPWFTP QSTYREATTV DCNDLRLTRI
PGNLSSDTQV LLLQSNYIAK TSEELEQLLN LTELDLSQNN FSNIHDIGLT NMSQLTTLHL
EENQIVEMPD FSLQDLTNLQ ELYINHNQIS FIAPNAFAGL RNLLRLHLNS NRLKAIDSRW
FDSTPNLEIL MIGENPVVGI LDLNFKPLVN LRSLVLAGME LTDIPGNAFV GLDNLESLSF
YDNKLVRVPQ NALEKLPNLK FLDLNKNPVH KIQGGDFKNM LRLKELGINN MGELVSIDRF
ALDNLPELTK LEATNNPKLS YISRLSFRDV PSLESLMLNN NALNSLYLAT VESLPNLREI
SIHSNPLRCD CVIQWMSSNK TTIRFMEPLS MYCAMPPEVR GQRMRDVLSH ESAEQCLPMI
SHDTFPNHLN LDIGMTVDLD CRAMAEPEPE IYWVTPLGNK VMMDTVSDKY RLSSAGTLHI
SNIQVDDSGH YTCVAQNTEG ADTRVTAIRV NGTLLDSTQL MKIYVKHTES HSILVSWKVN
SNVMTSNLKW SSATMKIDNP HITYTARVPV DVHEYNLTHL QPATEYEVCL SVSNIHQQTQ
KSCVNVTTKH ATFAVEIYEQ GTNTALAAVM GTILAIISLG SITVYIAKRW KRKNYHHSLK
KYMQKTSSIP LNELYPPLIN LWEVDSEKDK DGSSEPKPSQ VDTTRSYYMW
//
