ID W5LU97_ASTMX Unreviewed; 964 AA.
AC W5LU97;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Toll-like receptor 13 {ECO:0000313|Ensembl:ENSAMXP00000026713.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000026713.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000026713.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR AlphaFoldDB; W5LU97; -.
DR STRING; 7994.ENSAMXP00000026713; -.
DR Ensembl; ENSAMXT00000026734.2; ENSAMXP00000026713.2; ENSAMXG00000026008.2.
DR eggNOG; KOG4641; Eukaryota.
DR GeneTree; ENSGT00940000163999; -.
DR HOGENOM; CLU_006000_4_0_1; -.
DR InParanoid; W5LU97; -.
DR OrthoDB; 1207361at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000026008; Expressed in bone element and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF551; LOW QUALITY PROTEIN: TOLL-LIKE RECEPTOR 13-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 8.
DR SMART; SM00369; LRR_TYP; 15.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 6.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..37
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 38..964
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030179488"
FT TRANSMEM 751..774
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 804..945
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 964 AA; 110276 MW; C1AA2BD16C5AF46F CRC64;
MNMSTILHRG HHTPLVIFCT CLLLVLSCVV QIPPSNGFFV NNCNMRGSLK EPVNLTASCN
NRELNTVPQN LPDQTRVLDF SNNKLLNIKK TDFTHLTVLR QLNVSHNLIQ DIEDGAFVSL
TSLMELNLAY NKLTTISSGC FQNLFNLTLL RLDENNITYI TASAFVPLIS LVMLNLSGNN
LIHIYQAQPA FQLLHIQELY MGRNGFSYFQ SSEVSNTSLN LKVLDLSQNL LEVFKMTADI
FPQLESLDLA FSKGSIIWDV QDTNYFRNVR TLNLSGTHEK MEPVLQTFNS SLTSLRLYQF
REQKVKPLIT KACLIKSLRT LHLQLNSMEY ISEKELKNCT DLEVLDLSEN SLTNITNMAF
GSMTKLSRLS LSRNILDSVP TAIGSVSSLK TLDLSFNSIE VLTCSDFNNL IQLQTLNIYR
NPLSSIENCT FQNLINLKTL IISFSRLISV KHCFRMCLQK LEFLDLTQNK LNSIHKGDFG
DLQSLTHLLL NDNQISNIED GAFDGLNKLK VLYLQSNKIP TDSLKASVFS GLANLKCLML
NSNFFSYSYQ HNLIDPPFAD LESLETLAIH NQGHKGMTNI PSNFLQGLTS LQEFTAGNLN
LNSLDSKTFS HTPRLQSLDL RRNELTTVSP EVFEPLQQLS RLSMSSADLQ SLDFLMQANL
TEIQYLQVSR NALAVINQTL ISSFPKLVFI DLQENTFSCD CSNSWFVDWA QKNNDTQILN
ADKLTCNYPS NLRGSKLMAL DFESCTVDQG FYYFISTTIF ILLIMLSSIL HHFLKWQVVY
AYYRLLAFLY DSKQQRQNGK SSGFQYDAFI SYNTQDELWV MSELIPQVEG EQGWRLCLHH
RDFQPGKPIM ENIVDGIYRS RKTICVISRH YLESEWCSRE IQVASFRLFD EKKDVLILVF
LENIPAHQLS PYYRMRKLIK KRTYLSWPKP GEDTRVFWEK LRVALETKGT YEEESLLLSG
IRRT
//
