ID W5LUA3_ASTMX Unreviewed; 667 AA.
AC W5LUA3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=Leucine rich repeat containing 4.2 {ECO:0000313|Ensembl:ENSAMXP00000026719.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000026719.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000026719.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Synaptic cell membrane {ECO:0000256|ARBA:ARBA00034109}.
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DR AlphaFoldDB; W5LUA3; -.
DR STRING; 7994.ENSAMXP00000026719; -.
DR Ensembl; ENSAMXT00000026740.2; ENSAMXP00000026719.2; ENSAMXG00000026014.2.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000159260; -.
DR HOGENOM; CLU_000288_18_24_1; -.
DR InParanoid; W5LUA3; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000026014; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF9; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..667
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017305720"
FT TRANSMEM 519..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 347..436
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 567..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 667 AA; 74261 MW; 824A015923F96AB6 CRC64;
MSLLWQVTVH RAWNAALLCA VYLMVRAWSV CAAPTEPQNC PAVCSCSNQF SKVVCTRRSL
VRVPSGIPAN TRHLNLMENS IEIIQADTFR HLHHLEVLQL GRNSIRKIEV GAFNGLTNLN
TLELFDNRLT VIPSGAFEYL SKLRELWLRN NPIESIPSYA FNRVPSLMRL DLGELKKLEY
ISEGAFEGLY NLKYLNLGMC NLREMPVLSP LVGLEELEMS ENYFPEIKPG SFRGLKSLKK
LWIMNSRITT MERNAFDDVT ALVELNLAHN NLSSLPHDLF APLSYLVELH LHHNPWRCDC
DVVWLAWWLR EYIPTNSTCC GRCHTPAHLR GRYLVEVDQT TFQCSAPFIL DAPRDLNISA
ERVAELKCRT APMSSVRWLL PNGTVLTHGS NHPRIYVLND GTLNFSNVLA SDTGVYTCMV
TNMAGNSNAS AYLNVSAAEL NTSEHLSYFT TVTVEVVEPT SEEVIKPKTV TASPSVFQPV
FISTPTVLLQ TPRQVSVPTV RGTVRPPASL DEVMKTTKII IGCFVAVTLL AAVMLIAFYK
LRKRHQQRST VAAARTIEII QMEEDVPPAT SGTSIPGEGG MVLPSLRDRN STYKPSYSTY
KPAHSAPWTE NNIGNSLHRS RPTTISTIPE PYLIKTHTKE KDVAAGPVDP AHSLFAEAGV
QAGPINA
//