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Database: UniProt
Entry: W5LUA3_ASTMX
LinkDB: W5LUA3_ASTMX
Original site: W5LUA3_ASTMX 
ID   W5LUA3_ASTMX            Unreviewed;       667 AA.
AC   W5LUA3;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 59.
DE   SubName: Full=Leucine rich repeat containing 4.2 {ECO:0000313|Ensembl:ENSAMXP00000026719.2};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000026719.2, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000026719.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Synaptic cell membrane {ECO:0000256|ARBA:ARBA00034109}.
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DR   AlphaFoldDB; W5LUA3; -.
DR   STRING; 7994.ENSAMXP00000026719; -.
DR   Ensembl; ENSAMXT00000026740.2; ENSAMXP00000026719.2; ENSAMXG00000026014.2.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000159260; -.
DR   HOGENOM; CLU_000288_18_24_1; -.
DR   InParanoid; W5LUA3; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000026014; Expressed in brain and 3 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR24369:SF9; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00369; LRR_TYP; 8.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00013; LRRNT; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS51450; LRR; 3.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           33..667
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017305720"
FT   TRANSMEM        519..539
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          347..436
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   REGION          567..588
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   667 AA;  74261 MW;  824A015923F96AB6 CRC64;
     MSLLWQVTVH RAWNAALLCA VYLMVRAWSV CAAPTEPQNC PAVCSCSNQF SKVVCTRRSL
     VRVPSGIPAN TRHLNLMENS IEIIQADTFR HLHHLEVLQL GRNSIRKIEV GAFNGLTNLN
     TLELFDNRLT VIPSGAFEYL SKLRELWLRN NPIESIPSYA FNRVPSLMRL DLGELKKLEY
     ISEGAFEGLY NLKYLNLGMC NLREMPVLSP LVGLEELEMS ENYFPEIKPG SFRGLKSLKK
     LWIMNSRITT MERNAFDDVT ALVELNLAHN NLSSLPHDLF APLSYLVELH LHHNPWRCDC
     DVVWLAWWLR EYIPTNSTCC GRCHTPAHLR GRYLVEVDQT TFQCSAPFIL DAPRDLNISA
     ERVAELKCRT APMSSVRWLL PNGTVLTHGS NHPRIYVLND GTLNFSNVLA SDTGVYTCMV
     TNMAGNSNAS AYLNVSAAEL NTSEHLSYFT TVTVEVVEPT SEEVIKPKTV TASPSVFQPV
     FISTPTVLLQ TPRQVSVPTV RGTVRPPASL DEVMKTTKII IGCFVAVTLL AAVMLIAFYK
     LRKRHQQRST VAAARTIEII QMEEDVPPAT SGTSIPGEGG MVLPSLRDRN STYKPSYSTY
     KPAHSAPWTE NNIGNSLHRS RPTTISTIPE PYLIKTHTKE KDVAAGPVDP AHSLFAEAGV
     QAGPINA
//
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