ID W5LW95_LEPOC Unreviewed; 918 AA.
AC W5LW95;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000000402.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000000402.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5LW95; -.
DR STRING; 7918.ENSLOCP00000000402; -.
DR Ensembl; ENSLOCT00000000402.1; ENSLOCP00000000402.1; ENSLOCG00000000368.1.
DR eggNOG; ENOG502QS9E; Eukaryota.
DR GeneTree; ENSGT01100000263476; -.
DR InParanoid; W5LW95; -.
DR OMA; HEDTVKY; -.
DR Proteomes; UP000018468; Unassembled WGS sequence.
DR Bgee; ENSLOCG00000000368; Expressed in bone element and 10 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 4.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 127..259
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 918 AA; 104531 MW; 36DA6413DDA30BE7 CRC64;
MFTLEEQLTQ DVRRAVSDLT DELENFYTGG FQETDQGWLQ TLKDKHKEAL KIQFEVVSEG
ISKPGEQTLL KDIFTHVWIT EGSCVEVNHG HEIMQVETVS KNTKSEILSI KCSDIFKPLP
GQTRPIRTVL MKGVAGIGKT FSVQKFILDW ATGKDNQDFD FIFFLPFREL NMITSEKSLQ
ELVRCFSPEM KSYDNILEHC KVLFIFDGQD ESRHPLKFEE NEIWSDVKKP TSVDMLLTNL
IKGNFPIDSS IWITSRPAAA GLIPPELINR VTEVQGFEDQ QKEEYIRKKC KNRALADRII
SHIKTLRSLY ILCYVPVFCW IVVTVLEHTL EDKSFDNPKT LTDFYTVFLI VLLTAKEQKK
EKENVLKSNQ EAILKLGKLA FESLKKNIIV FYEKDLREYD IDLNSPIYSG VCKEIFKQNS
ALFQEKVYCF LHLTVQEYFA ALHVFGSYQN YNINPLQETM WSFSWLEQFL YPSIIPLFSL
NKGALEKAIQ SRTGHLDMFV RFLLGMGMKN NQELLKGFLS GTKDHSNDIQ ETAGYIKELI
RETSSPERCF NLFHCLSELK DKSLIEEFNV TLDKTKLSGQ SLSPSQCSAL TYYTLLSEKE
IEVFDMSEYA TSEECVRRLL PVAKITKTLR ELWFCGTSEA SPGVASGVLR RYPVHIREMF
LTKTSVGEGG SKWLSESLLE DTYCRTEKNL FLVLYNAQEG SLALRGFHES VAGNLLVENP
VHYPGCQLVC SGLQQPCCCV QVCRMLNCEL TERCCEDLAS VLLSQHSSLR GLDLSYNNLG
DSEVKLLSEA LRDPNCKLTK LEMSWCKLTE RCCENLASAL QSQCSSLREL DLSYNNLGDS
GVKLLSAALK DPNCKLTTLR MRDCELTERC CEDLASALQS QHSSLRELDL SHNNLGDSGV
KLLSATLRDP NCKLATLR
//
