ID W5LX15_LEPOC Unreviewed; 406 AA.
AC W5LX15;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Tyrosine-protein kinase STYK1-like {ECO:0000313|Ensembl:ENSLOCP00000000672.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000000672.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000000672.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AHAT01030066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5LX15; -.
DR STRING; 7918.ENSLOCP00000000672; -.
DR Ensembl; ENSLOCT00000000675.1; ENSLOCP00000000672.1; ENSLOCG00000000592.1.
DR eggNOG; KOG0200; Eukaryota.
DR GeneTree; ENSGT00940000157871; -.
DR HOGENOM; CLU_000288_7_7_1; -.
DR InParanoid; W5LX15; -.
DR OMA; PERIMML; -.
DR Proteomes; UP000018468; Linkage group LG25.
DR Bgee; ENSLOCG00000000592; Expressed in mesonephros and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0019838; F:growth factor binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IBA:GO_Central.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR CDD; cd00192; PTKc; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR24416:SF592; SERINE_THREONINE_TYROSINE KINASE 1; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PIRSF; PIRSF000615; TyrPK_CSF1-R; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Magnesium {ECO:0000256|PIRSR:PIRSR000615-3};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000615-3};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 108..381
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 244
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
FT BINDING 249
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
SQ SEQUENCE 406 AA; 45929 MW; DB2A6EEA4A495C3E CRC64;
MDDLTPQCNS SSQEYPCRYR NPDDQGTQYA LIIIPVFLGV TTVLTITLIL WKTCCRKWEQ
ERAPIASLQD KPVSSESGYV AMAAVEHTLL PVRDPGLRQW EIPGDTAIED LEFLRSGRFG
PVCRAKLTQG GSSTAVVIKT LRDNSTTSKA KEFVNWIRFC ARVCCHDNLV KMMFCQTELW
PMYLIMEACS PGNLLHLLWE LRKSDGESVD QVHEFSETSV YCIGKQVLAG LDYLASEQKL
IHGDVAARNV LINSRLGVKI SGLSLAFEVQ QTGCVSSRSA AVVPVKWLAP ERIMKLPMTV
KSDIWSFGIL LYELITLGSP PYPELKPLDT FPKLQHYYRM KRPDHCGAPL YDLMKHCWMW
LPQDRPSFSA VIKHLDSYMY LAETKMICNK ESMNMNQYSL IAGVVL
//
