ID W5M0X9_LEPOC Unreviewed; 428 AA.
AC W5M0X9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=WW domain containing transcription regulator 1 {ECO:0000313|Ensembl:ENSLOCP00000002036.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000002036.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000002036.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AHAT01022467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01022468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01022469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5M0X9; -.
DR STRING; 7918.ENSLOCP00000002036; -.
DR Ensembl; ENSLOCT00000002041.1; ENSLOCP00000002036.1; ENSLOCG00000001759.1.
DR eggNOG; KOG0940; Eukaryota.
DR GeneTree; ENSGT00510000046760; -.
DR HOGENOM; CLU_041917_0_0_1; -.
DR InParanoid; W5M0X9; -.
DR OMA; AVNTPAM; -.
DR Proteomes; UP000018468; Linkage group LG14.
DR Bgee; ENSLOCG00000001759; Expressed in zone of skin and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0034672; P:anterior/posterior pattern specification involved in pronephros development; IEA:Ensembl.
DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl.
DR GO; GO:0046844; P:chorion micropyle formation; IEA:Ensembl.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0061371; P:determination of heart left/right asymmetry; IEA:Ensembl.
DR GO; GO:0048566; P:embryonic digestive tract development; IEA:Ensembl.
DR GO; GO:0072148; P:epithelial cell fate commitment; IEA:Ensembl.
DR GO; GO:1905590; P:fibronectin fibril organization; IEA:Ensembl.
DR GO; GO:0035329; P:hippo signaling; IBA:GO_Central.
DR GO; GO:0070121; P:Kupffer's vesicle development; IEA:Ensembl.
DR GO; GO:0048387; P:negative regulation of retinoic acid receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0003406; P:retinal pigment epithelium development; IEA:Ensembl.
DR GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
DR GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; IEA:Ensembl.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 6.20.430.10; -; 1.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR17616:SF6; WW DOMAIN-CONTAINING TRANSCRIPTION REGULATOR PROTEIN 1; 1.
DR PANTHER; PTHR17616; YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER; 1.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS01159; WW_DOMAIN_1; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 112..145
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 178..211
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT REGION 47..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..239
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 428 AA; 47383 MW; 61715273A4B30EE9 CRC64;
PLQPLPGQQV IHVAQDLDTD LEALFNSVMN PKPSSWRKKV LPESFFKEPD SGSHSRQSST
DSGSQAPRLT VQHARSYSSP ASFRLETGAS ATPSPEHHAH LRQQSFDVAD ELPLPPGWEM
AFTSNGQRYF LNHVEKVTTW QDPRKAMTSA VTPMSLHAPA TPAPVQQRPM ALSQPNLGQL
PEGWEQAVTP QGEIYFIDHK TQSTSWLDPR VDTRLMLSHH PQHPQRQPPP PPQVPPSPAV
SQQSAPLMTL PHPLTTQQQH QQKMRLQRIQ LERERIRKRQ EELMRQEVAL CRQLPMESEG
MLAVPPAVGS AAMTQDMRTV PSHGSDPFLN SGPYHSREQS TDSGLGLGCY SIPTTPEDFL
GNVDEMDTGD SMGTGTMSVG PQTRFPDFLD SLPGTNVDLG TLEGADLIPI LNDVESVLNK
SEPFLTWL
//
