ID   W5M1C4_LEPOC            Unreviewed;       483 AA.
AC   W5M1C4;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Ubiquitin-conjugating enzyme E2 variant 3-like {ECO:0000313|Ensembl:ENSLOCP00000002181.1};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000002181.1, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000002181.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AHAT01008151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_015193802.1; XM_015338316.1.
DR   RefSeq; XP_015193803.1; XM_015338317.1.
DR   AlphaFoldDB; W5M1C4; -.
DR   STRING; 7918.ENSLOCP00000002181; -.
DR   Ensembl; ENSLOCT00000002187.1; ENSLOCP00000002181.1; ENSLOCG00000001881.1.
DR   GeneID; 102684430; -.
DR   KEGG; loc:102684430; -.
DR   CTD; 55293; -.
DR   eggNOG; KOG1495; Eukaryota.
DR   eggNOG; KOG2391; Eukaryota.
DR   GeneTree; ENSGT00940000153903; -.
DR   HOGENOM; CLU_039842_0_1_1; -.
DR   InParanoid; W5M1C4; -.
DR   OMA; CIMGANG; -.
DR   OrthoDB; 5344346at2759; -.
DR   Proteomes; UP000018468; Linkage group LG27.
DR   Bgee; ENSLOCG00000001881; Expressed in ovary and 13 other cell types or tissues.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0004459; F:L-lactate dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0006089; P:lactate metabolic process; IBA:GO_Central.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:InterPro.
DR   GO; GO:0006090; P:pyruvate metabolic process; IBA:GO_Central.
DR   Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR   InterPro; IPR001557; L-lactate/malate_DH.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   InterPro; IPR008883; UEV_N.
DR   PANTHER; PTHR43128; L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)); 1.
DR   PANTHER; PTHR43128:SF32; UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 3; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   Pfam; PF05743; UEV; 1.
DR   PRINTS; PR00086; LLDHDRGNASE.
DR   SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF54495; UBC-like; 1.
DR   PROSITE; PS51322; UEV; 1.
PE   4: Predicted;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT   DOMAIN          2..145
FT                   /note="UEV"
FT                   /evidence="ECO:0000259|PROSITE:PS51322"
FT   REGION          362..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        362..383
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   483 AA;  52279 MW;  F081D9396CF3372E CRC64;
     MDLSQESIRK TLGKYKFRDV AIEELQKVHR VNPGFKPLVD TYTFSDSSQK DLLKLVGNIP
     VSYQGRSYNL PILLWLLDSF PFTPPICLLR PTPSMMIRVG KHVDARGRIY LPYLHNWDHP
     ASSVNGLLSE MIAKFEEEPP LCTKPSADEK DPAELLAYVE KISGGMSTMN IGPPASVGRV
     YPERPVNKVT VVGGGDLGVA CLMSILAKGS VDKIVLIDFS EHSSKGGTMD LEIFSLPKVE
     VARDLSASAD SKVVVVTSNA WSDDESFVSV VQTNVDLYQG IIPCLARCSP SAVLLIASQP
     VDIMTHVAWK QSGLPPSRVI GTGCNLDSER LNYIVSTVLL SRAAGSQPWV VGELSDSKVP
     AWSSSAPATD SQPEITPGPT STKPLTDRAF EILKGRGQRS LSVGLSVADI VHSILADQRK
     THSVSTLAQG WGGVCGEVFL SLPCELGTGG VARISKLTLG QEEDLKLRNS ATSLRNFIQQ
     LRI
//