ID W5M2P3_LEPOC Unreviewed; 462 AA.
AC W5M2P3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Chordin like 2 {ECO:0000313|Ensembl:ENSLOCP00000002651.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000002651.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000002651.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; AHAT01003315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5M2P3; -.
DR Ensembl; ENSLOCT00000002657.1; ENSLOCP00000002651.1; ENSLOCG00000002265.1.
DR GeneTree; ENSGT00940000166571; -.
DR HOGENOM; CLU_048288_1_0_1; -.
DR Proteomes; UP000018468; Linkage group LG3.
DR Bgee; ENSLOCG00000002265; Expressed in zone of skin and 11 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR InterPro; IPR045717; CHRDL1/2.
DR InterPro; IPR045716; CHRDL_1/2_C.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46303:SF3; CHORDIN-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR46303; VWFC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF19548; CHRDL_1_2_C; 1.
DR Pfam; PF00093; VWC; 3.
DR SMART; SM00214; VWC; 3.
DR SUPFAM; SSF57603; FnI-like domain; 3.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 3.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..462
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004867163"
FT DOMAIN 40..105
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 120..186
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 265..328
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 194..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 462 AA; 51868 MW; 54327F71C7A247E5 CRC64;
DPAQWRKIVS GMKHLFVFFS LALYIILDVE AIRTRKIPGT FCTFKEKRYS PGDSWHPYLE
PYGFVLCMRC TCAETGHVNC NAIKCPVLRC KNPVTDSQQC CPRCADEESR SPAGLRTLGK
SCQYNGILYQ PGETFSNDEL FPSRLPNQCV TCSCSNGNIF CALKTCSRVS CASPVSVQDS
CCPLCKDVNI NSASTEDSGQ QLNRGAKWKR HSKDQCSGDP GENVAGRETP SAIRSSSRAL
NLPAFRHGGA AGTTVKILLQ RKHKRACVYN GKTYSHGDLW HPELGKVLEC ILCTCKDGVQ
ECKRITCPRE YPCEHPEKTE GECCKTCPAE QKTEQNRTQC SPGKDSAEFL VYKVGSGTDS
TVRKIAIERQ GAAELEVHVW KTVEGSLHFM ETEELQRETL MEDPENYVFL TRLDEETWKK
FKEQEAHRKE NPETRTCDDG MREVLQFLYP EQLDSLCALS LS
//
