ID W5M5S0_LEPOC Unreviewed; 988 AA.
AC W5M5S0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Myosin XIX {ECO:0000313|Ensembl:ENSLOCP00000003728.1};
GN Name=MYO19 {ECO:0000313|Ensembl:ENSLOCP00000003728.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000003728.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000003728.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; AHAT01005672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006641060.1; XM_006640997.2.
DR AlphaFoldDB; W5M5S0; -.
DR STRING; 7918.ENSLOCP00000003728; -.
DR Ensembl; ENSLOCT00000003735.1; ENSLOCP00000003728.1; ENSLOCG00000003147.1.
DR GeneID; 102690362; -.
DR KEGG; loc:102690362; -.
DR CTD; 80179; -.
DR eggNOG; KOG0160; Eukaryota.
DR GeneTree; ENSGT00940000157382; -.
DR InParanoid; W5M5S0; -.
DR OMA; CSLETTW; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000018468; Linkage group LG22.
DR Bgee; ENSLOCG00000003147; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0031982; C:vesicle; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR GO; GO:0030050; P:vesicle transport along actin filament; IBA:GO_Central.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF289; UNCONVENTIONAL MYOSIN-XIX; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 2.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 73..781
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..658
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 170..177
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 988 AA; 111401 MW; 9E59331EEFC90518 CRC64;
MASAKPKQRG SSRRAFPDGP EEVGAGAGSR GWEYRPARRP GSQKKTIPSP HPSLDDSLEG
DLQNFLIDES QLHTYDDLTK VNPVTTTTVL KCLQARYCAR VFYTHAGCTL VALNPFQPIP
QLYSPDVMKE YHSAARPQEF KPHIFIVAEQ AYRNVQGQVE PVNQSLVVSG ESGAGKTWTS
RCLMKYYATV AASRSSQKAQ DTVERIERRV LDSNPIMEAF GNACTLRNHN SSRFGKYIQL
QLNRSQQLVG ASVQTYLLEK TRVACQAPGE RNFHIFYQMM KGATQEERQE WKMPAAGQFL
WLPNADRTLE EDCFEETRAA MLHLGVHKEV QGQIFQVLAA LLQLGNVQFS CPPDESQPCE
LQEQSKDFLQ NAACLLRVPA EELLSCLRVR TIRAGRQQHT VMKPCSQTEC SMRRDCLAKV
IYAHIFDWIV AFINQSICAD SSSWCNFIGL LDVYGFECFH QNNLEQLCIN YANEKLQQHF
VAHYLKAQQE EYAAEGLEWS FISYQDNQSG LDLIEGPPPS VFSLLNEECR LNRPSDAKQF
ETRLEKALSG KACVSWDKLS DTPHFTVSHY AGQVSYQIEG MVEKNKDLVP PELVLVLRRS
QDALLHSLFS ENNQEQSDSK GHSKVITVVS KFKGSLESLM RVLHSTTPHY TRCIKPNTDC
RPLTFKKEEV ITQLEACGIV ETINISAAGF PVRIPYPSFV KRYGLITLSK ISSVSNGSGS
EDERDTLGSA VRHVLRFVTP GQPLDPFDPS EGRLRSTQVH CGKTKVFLTH AMLERLEIER
GRALACRAYS IQRCWRRYCH RKRERQRRAA TLIQAGVRSW LTRREILKWQ TAATVIQRAW
RTWRAVMEAL ADAELDDAVD IEEVTISLPG SPIPVTRPAQ FPQGQPVVVQ NWPIGLALAS
FAATSVAVTS SGFQKLVSLM ACLQLSFRRI DYKVETNQFD QGVASIRAHP RQSVKFHLQR
SPLLYADICP EQKADGISGF NQILLEKT
//
