ID W5M5U7_LEPOC Unreviewed; 220 AA.
AC W5M5U7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Neurturin {ECO:0000313|Ensembl:ENSLOCP00000003755.1};
GN Name=NRTN {ECO:0000313|Ensembl:ENSLOCP00000003755.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000003755.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000003755.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC {ECO:0000256|ARBA:ARBA00009832}.
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DR EMBL; AHAT01011181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5M5U7; -.
DR STRING; 7918.ENSLOCP00000003755; -.
DR Ensembl; ENSLOCT00000003762.1; ENSLOCP00000003755.1; ENSLOCG00000003179.1.
DR eggNOG; ENOG502QWH4; Eukaryota.
DR GeneTree; ENSGT00950000182993; -.
DR InParanoid; W5M5U7; -.
DR OMA; CRPTEYD; -.
DR Proteomes; UP000018468; Linkage group LG19.
DR Bgee; ENSLOCG00000003179; Expressed in camera-type eye and 5 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd19383; TGF_beta_Neurturin; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR043401; GDNF_fam.
DR InterPro; IPR001839; TGF-b_C.
DR PANTHER; PTHR12173; GDNF SUBFAMILY OF TGF-BETA FAMILY; 1.
DR PANTHER; PTHR12173:SF3; NEURTURIN; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 114..220
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 220 AA; 24565 MW; 8A56D81138D97E90 CRC64;
MLCGAALSVF LCRNMIPGGE GPGAWPSSSS STISSSWLKG HHRAVRAADK PSLFRECYGL
SDKGRKSAGN KSYRSYISYL LQSYTEGEVK QLISALVDRS GPEDSRLDLS LSKRTKRARK
GLLKPCSLKE LEVSVSQLGL GYEGDEILLF RYCSGRCQEA RRNYDLTLEH MKKQGRVKKG
KARHKPCCRP TEYDDDISFL DNGNKYHTIR EVSARKCGCV
//
