ID W5M8T5_LEPOC Unreviewed; 343 AA.
AC W5M8T5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=TGF-beta family profile domain-containing protein {ECO:0000259|PROSITE:PS51362};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000004794.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000004794.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; AHAT01012524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5M8T5; -.
DR STRING; 7918.ENSLOCP00000004794; -.
DR Ensembl; ENSLOCT00000004802.1; ENSLOCP00000004794.1; ENSLOCG00000004013.1.
DR eggNOG; ENOG502S539; Eukaryota.
DR GeneTree; ENSGT00400000024763; -.
DR HOGENOM; CLU_808827_0_0_1; -.
DR InParanoid; W5M8T5; -.
DR Proteomes; UP000018468; Linkage group LG2.
DR Bgee; ENSLOCG00000004013; Expressed in zone of skin and 8 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19379; TGF_beta_GSDF; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR PANTHER; PTHR11848:SF43; GROWTH_DIFFERENTIATION FACTOR 6; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..343
FT /note="TGF-beta family profile domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004867780"
FT DOMAIN 108..219
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 343 AA; 37295 MW; 096D82FF0ABE2766 CRC64;
MSILLFLVAF LFGCPVGKAS TLRPSRVLPS AGPVASVSDV PVVPMTSCQG EPLQTIRTKL
LEAFSLKQAP DVNPEGMSEL RDHWKAALSV FSKNSETSET ATVGNTVTLQ ESYLNNSKST
TTRVSCCKMT SQVFIKDLGW ETWILHPESF AYAQCVACAP HRDRARLRCG PAGLASRHHA
PQVSCCGPVA FRMVPFIYLD HHSTLTISNI PLVQDCSCTT DPGTGAAGEY CFPTKVRCTK
GQYLQSVFVL LPVETGTQAV DGPVALRPSS SSSLDERDLV RLHQGQTGLV DNCGLRFNVT
EAFTARQGGK AFCVEIVSEQ GTPALKCEPF LATVWWRQRR PPD
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