ID W5M9G0_LEPOC Unreviewed; 591 AA.
AC W5M9G0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Mitoguardin 2 {ECO:0000256|ARBA:ARBA00040959};
DE AltName: Full=Protein FAM73B {ECO:0000256|ARBA:ARBA00041863};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000005019.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000005019.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004374}.
CC -!- SIMILARITY: Belongs to the mitoguardin family.
CC {ECO:0000256|ARBA:ARBA00008969}.
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DR EMBL; AHAT01025372; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01025373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01025374; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01025375; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006640745.1; XM_006640682.2.
DR RefSeq; XP_015222365.1; XM_015366879.1.
DR RefSeq; XP_015222366.1; XM_015366880.1.
DR AlphaFoldDB; W5M9G0; -.
DR STRING; 7918.ENSLOCP00000005019; -.
DR Ensembl; ENSLOCT00000005027.1; ENSLOCP00000005019.1; ENSLOCG00000004191.1.
DR GeneID; 102696997; -.
DR KEGG; loc:102696997; -.
DR CTD; 84895; -.
DR eggNOG; KOG3831; Eukaryota.
DR GeneTree; ENSGT00390000008565; -.
DR HOGENOM; CLU_031519_2_1_1; -.
DR InParanoid; W5M9G0; -.
DR OMA; AHFYVIS; -.
DR OrthoDB; 2883389at2759; -.
DR Proteomes; UP000018468; Linkage group LG21.
DR Bgee; ENSLOCG00000004191; Expressed in liver and 13 other cell types or tissues.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008053; P:mitochondrial fusion; IBA:GO_Central.
DR InterPro; IPR019392; Miga.
DR PANTHER; PTHR21508; MITOGUARDIN; 1.
DR PANTHER; PTHR21508:SF4; MITOGUARDIN 2; 1.
DR Pfam; PF10265; Miga; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 65..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 591 AA; 65983 MW; 9D80A1687DA43E22 CRC64;
MSMRRTEGVS VIQALAMTVA EIPMFLYSTF GQSIFSQLRL SPSLKKVLFA TALGSVALAL
TAHHLKRRGH KRKKITQGKD VPKQTNVPES LLGNGRRQSS LKKAPYPGRR VTSPSSRSND
TLSGISSIAP SKHSSSSHSL ASVRIPPSPN QATNPAAPWE AEAVEEESGM AEDSNAENLY
IMGMELFEEA LQKWELALNV RHRRRSEATG SSSLVLQGAS AAEKPESEPR NNVFAEKLET
LLHRAYHLQE EFGSTIPPDS LLPDFESEGT LILPNESSHR LPMDDGASIT SDDSFFSAAE
LFDTMSFDEV YRPSRLAALY EEALALVKEG KVSCRTLRTE LLECYSDQDF LAKLHCVRQA
FEVVLLDENQ QVFFSEIGKQ MITGLMAKAN KSPKGFLESY EEMLRYTQRE ETWPTTKMEL
EGRGVVCMNF FDIVLDFILM DAFEDLESPP SSVVAVLRNR WLSDSFKETA LATACWSVLK
AKRRLLMVPD GFISHFYSIS EHVSPVLAFG FLGPRQHLSE VCSIFKQQIV QYLKDMFDHD
KVRFTTAQSL ADDILRLSRR RSEILLGYLG IDSLVEPNGS LPLSNGPSEH N
//
