ID W5MA41_LEPOC Unreviewed; 803 AA.
AC W5MA41;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Leucine rich repeat containing 8 VRAC subunit A {ECO:0000313|Ensembl:ENSLOCP00000005250.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000005250.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000005250.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00024167};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324,
CC ChEBI:CHEBI:16382; Evidence={ECO:0000256|ARBA:ARBA00024145};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328,
CC ChEBI:CHEBI:507393; Evidence={ECO:0000256|ARBA:ARBA00024158};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LRRC8 family.
CC {ECO:0000256|ARBA:ARBA00010471}.
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DR EMBL; AHAT01025383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006640722.1; XM_006640659.2.
DR RefSeq; XP_015222419.1; XM_015366933.1.
DR RefSeq; XP_015222420.1; XM_015366934.1.
DR RefSeq; XP_015222422.1; XM_015366936.1.
DR RefSeq; XP_015222423.1; XM_015366937.1.
DR AlphaFoldDB; W5MA41; -.
DR STRING; 7918.ENSLOCP00000005250; -.
DR Ensembl; ENSLOCT00000005258.1; ENSLOCP00000005250.1; ENSLOCG00000004397.1.
DR GeneID; 102692443; -.
DR KEGG; loc:102692443; -.
DR CTD; 327642; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000154043; -.
DR HOGENOM; CLU_019019_0_0_1; -.
DR InParanoid; W5MA41; -.
DR OMA; CKWILND; -.
DR OrthoDB; 55205at2759; -.
DR Proteomes; UP000018468; Linkage group LG21.
DR Bgee; ENSLOCG00000004397; Expressed in larva and 13 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021040; LRRC8_Pannexin-like.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF3; LEUCINE RICH REPEAT CONTAINING 8 VRAC SUBUNIT A; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF12534; Pannexin_like; 1.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 8.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 4.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 27..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..333
FT /note="LRRC8 pannexin-like TM region"
FT /evidence="ECO:0000259|Pfam:PF12534"
SQ SEQUENCE 803 AA; 93642 MW; 7DB48443F1A0B7A2 CRC64;
MIPITELRYF ADTQPAYRIL KPWWDVFTDY ISIVMLMIAV FGGTLQVTQD KMICLPCKWV
VNKTCDPFSP KKYINSSVRP SPLVYEPKGI QYDLDRHQYN YVDAVCYENK LHWFAKYFPY
LVLLHTLIFL ACSNFWFKFP RTSSKLEHFV SILLKCFDSP WTTRALSETV VEESDPKPAL
GKMNGSMDKK ASSVSEDVEA SVPMLQRTKS RIEQGIVDRS ETGVLDKKEG EQAKALFEKV
KKFRTHVEEG DIVYRLYIRQ TIIKVIKFIL IICYTGYYVN NIKFDVDCSV DIENLTGYQM
YRCAHPLATL FKILASFYIS LVVVYGLICM YTLCWMLRRS LKKYSFESIR EESSYSDIPD
VKNDFAFMLH MIDQYDPLYS KRFAVFLSEV SENKLRQLNL NNEWTLDKLR QRITKNSHDK
LELHLFMLSG IPDTVFDLLE LEVLKLELIP DVTIPPIIAQ LTNLKEMWLY HTPAKIEAPA
LAFLRENLKS LHIKFTDIKE IPLWIYSLKN LSELHLTGNL SAENNRYIVI DGLRELKRLK
VLRLKSNLTK LPQVVTDVGV HLQKLSVNNE GTKLMVLNSL KKMVNLTELE LIRCDLERIP
HSIFSLHNLQ EIDLKDNNLK TIEEIISFQH LHRLVCLKLW YNQIAYIPIQ IGTLTNLERL
YLNRNKIEKI PSQLFFCRKL RFLDLSHNNL TYIPADIGFL QNLQYFAVTA NRIENLPPEL
FQCKKLRTLN LGNNCLQSLP SRFGELTSLT QLELRGNRLE CLPVELGECR LLKRSGVIVE
EDLFNTLPSE VKEQLWRADK EQA
//
