ID   W5MBP9_LEPOC            Unreviewed;       995 AA.
AC   W5MBP9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=Pre-mRNA-processing factor 6 {ECO:0000256|ARBA:ARBA00020235};
DE   AltName: Full=PRP6 homolog {ECO:0000256|ARBA:ARBA00032140};
DE   AltName: Full=U5 snRNP-associated 102 kDa protein {ECO:0000256|ARBA:ARBA00031070};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000005808.1, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000005808.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AHAT01025249; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006639651.2; XM_006639588.2.
DR   AlphaFoldDB; W5MBP9; -.
DR   STRING; 7918.ENSLOCP00000005808; -.
DR   Ensembl; ENSLOCT00000005816.1; ENSLOCP00000005808.1; ENSLOCG00000004827.1.
DR   GeneID; 102698106; -.
DR   KEGG; loc:102698106; -.
DR   CTD; 24148; -.
DR   eggNOG; KOG0495; Eukaryota.
DR   GeneTree; ENSGT00550000075016; -.
DR   InParanoid; W5MBP9; -.
DR   OMA; DGWAWYY; -.
DR   OrthoDB; 655233at2759; -.
DR   Proteomes; UP000018468; Linkage group LG18.
DR   Bgee; ENSLOCG00000004827; Expressed in ovary and 13 other cell types or tissues.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR010491; PRP1_N.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR11246; PRE-MRNA SPLICING FACTOR; 1.
DR   PANTHER; PTHR11246:SF1; PRE-MRNA-PROCESSING FACTOR 6; 1.
DR   Pfam; PF06424; PRP1_N; 1.
DR   Pfam; PF14559; TPR_19; 2.
DR   SMART; SM00386; HAT; 14.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; TPR-like; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          68..223
FT                   /note="PRP1 splicing factor N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06424"
FT   REGION          1..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          159..209
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..57
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..123
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   995 AA;  111160 MW;  977CD0084008B3D6 CRC64;
     MASVSTTPAS RNASKMASSS AGAAGSSSGS GSGSGGGNVA SSLSGTGATS SLTGTLNKKK
     KPFLGMPAPL GYVPGLGRGA TGFTTRSDIG PARDANDPVD DRHAPPGKRT VGDQMKKNQA
     DDDDEDLNDT NYDEFNGYAG SLFSSGPYEK DDEEADAIYA ALDKRMDERR KERREQREKE
     EIEKYRMERP KIQQQFSDLK RKLAEVTEEE WLSIPEVGDA RNKRQRNPRY EKLTPVPDSF
     FAKHLQTGEN HTSVDPRQGQ FGGLNTPFSG GLNTPYPGAM TPGLMTPGTG ELDMRKIGQA
     RNTLMDMRLS QVSDSVSGQT VVDPKGYLTD LNSMIPTHGG DINDIKKARL LLKSVRETNP
     HHPPAWIASA RLEEVTGKLQ VARNLIMKGT EMCPKSEDVW LEAARLQPGD TAKAVVAQAV
     RHLPQSVRIY IRAAELETDI RAKKRVLRKA LENVSKSVRL WKAAVELEEP EDARIMLSRA
     VECCPTSVEL WLALARLETY ENARRVLNKA RENIPTDRHI WITAAKLEEA NGNTQMVEKI
     IDRAITSLRA NGVEINREQW IQDAEECDKA GSVATCQAVI RAVIGIGIEE EDCKHTWMED
     AESCIAHGAL ECARAIYAHA LQVFPSKKSV WLRAAYFEKS HGTRESLEAL LQRAVAHCPK
     AEVLWLMGAK SKWLAGDVPA ARSILALAFQ ANPNSEEIWL AAVKLESENN EYERARRLLA
     KARSSAPTAR VFMKSVKLEW VLGNISAAQE LCVEALKHYE DFPKLWMMKG QIEEQSQCMD
     KAREAYNQGL KKCPHSIPLW LLLSRLEEKA GQLTRARAIL EKSRLKNPQN PELWLESVRL
     EYRAGLKNIS NTLMAKALQE CPNSGILWAE AIFLESRPQR KTKSVDALKK CEHDPHVLLA
     VAKLFWSERK ITKAREWFLR TVKIEPDLGD AWALFYKFEI QHGTEEQQEE VKRRCENAEP
     RHGELWCAES KHIHNWQKKI GEILVLVAAK IKNTF
//