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Database: UniProt
Entry: W5MDM8_LEPOC
LinkDB: W5MDM8_LEPOC
Original site: W5MDM8_LEPOC 
ID   W5MDM8_LEPOC            Unreviewed;       414 AA.
AC   W5MDM8;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=Argininosuccinate synthase {ECO:0000256|ARBA:ARBA00014810};
DE            EC=6.3.4.5 {ECO:0000256|ARBA:ARBA00012286};
DE   AltName: Full=Citrulline--aspartate ligase {ECO:0000256|ARBA:ARBA00029916};
GN   Name=ASS1 {ECO:0000313|Ensembl:ENSLOCP00000006487.1};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000006487.1, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000006487.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC       from L-ornithine and carbamoyl phosphate: step 2/3.
CC       {ECO:0000256|ARBA:ARBA00004967}.
CC   -!- PATHWAY: Nitrogen metabolism; urea cycle; (N(omega)-L-
CC       arginino)succinate from L-aspartate and L-citrulline: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00005154}.
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DR   EMBL; AHAT01024906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01024907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01024908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01024909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01024910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01024911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01024912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006640802.1; XM_006640739.2.
DR   RefSeq; XP_015222542.1; XM_015367056.1.
DR   AlphaFoldDB; W5MDM8; -.
DR   STRING; 7918.ENSLOCP00000006487; -.
DR   Ensembl; ENSLOCT00000006495.1; ENSLOCP00000006487.1; ENSLOCG00000005378.1.
DR   GeneID; 102691445; -.
DR   KEGG; loc:102691445; -.
DR   CTD; 445; -.
DR   eggNOG; KOG1706; Eukaryota.
DR   GeneTree; ENSGT00390000004524; -.
DR   InParanoid; W5MDM8; -.
DR   OMA; ACGAFHI; -.
DR   OrthoDB; 350199at2759; -.
DR   UniPathway; UPA00068; UER00113.
DR   UniPathway; UPA00158; UER00272.
DR   Proteomes; UP000018468; Linkage group LG21.
DR   Bgee; ENSLOCG00000005378; Expressed in pharyngeal gill and 13 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004055; F:argininosuccinate synthase activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006526; P:arginine biosynthetic process; IBA:GO_Central.
DR   GO; GO:0000053; P:argininosuccinate metabolic process; IBA:GO_Central.
DR   GO; GO:0000050; P:urea cycle; IBA:GO_Central.
DR   CDD; cd01999; Argininosuccinate_Synthase; 1.
DR   Gene3D; 3.90.1260.10; Argininosuccinate synthetase, chain A, domain 2; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 1.20.5.470; Single helix bin; 1.
DR   HAMAP; MF_00005; Arg_succ_synth_type1; 1.
DR   InterPro; IPR048268; Arginosuc_syn_C.
DR   InterPro; IPR048267; Arginosuc_syn_N.
DR   InterPro; IPR001518; Arginosuc_synth.
DR   InterPro; IPR018223; Arginosuc_synth_CS.
DR   InterPro; IPR023434; Arginosuc_synth_type_1_subfam.
DR   InterPro; IPR024074; AS_cat/multimer_dom_body.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   NCBIfam; TIGR00032; argG; 1.
DR   PANTHER; PTHR11587; ARGININOSUCCINATE SYNTHASE; 1.
DR   PANTHER; PTHR11587:SF2; ARGININOSUCCINATE SYNTHASE; 1.
DR   Pfam; PF20979; Arginosuc_syn_C; 1.
DR   Pfam; PF00764; Arginosuc_synth; 1.
DR   SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR   SUPFAM; SSF69864; Argininosuccinate synthetase, C-terminal domain; 1.
DR   PROSITE; PS00564; ARGININOSUCCIN_SYN_1; 1.
DR   PROSITE; PS00565; ARGININOSUCCIN_SYN_2; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW   Arginine biosynthesis {ECO:0000256|ARBA:ARBA00022571};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Urea cycle {ECO:0000256|ARBA:ARBA00022436}.
FT   DOMAIN          8..170
FT                   /note="Arginosuccinate synthase-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00764"
FT   DOMAIN          180..403
FT                   /note="Arginosuccinate synthase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF20979"
SQ   SEQUENCE   414 AA;  46711 MW;  3CB80723DB3F9303 CRC64;
     MSKSKGTVVL AYSGGLDTSC ILVWLKEQGY DVIAYLANIG QDEDFDAAQK KAQSLGAKKV
     FIEDLRAEFV EEFIWPAVQA SAIYEDRYLL GTSIARPCIA RRQVKIAQRE GAQFVSHGAT
     GKGNDQIRFE LTCYALYPEV KIIAPWRIPE FYNRFKGRKD LMDFAQKHGI SVPVTPKAPW
     SMDANLMHIS YESGILENPK NHAPDDLYQM TKNPAESPDS PDVLEIEFAK GVPVKVTNVK
     EGKCVDSALQ IFMYLNEIGG KHGVGRVDIV ENRFIGMKSR GIYETPGGTI LYHAHLDIET
     FTMDREVRKL KQGLGVKFSE LIYNGFWYSP ECEFVRHCIQ KSQENVEGKV QVSVLKGQVY
     ILGRESRKSL YNEELVSMDV QGDYDPCDAS GFIKINAVRL KEYHRLLSQA DSQH
//
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