UniProt: W5MDT0

Database: UniProt
Entry: W5MDT0_LEPOC

LinkDB:  W5MDT0_LEPOC 
Original site:  W5MDT0_LEPOC

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Ontology (9)   
   GO (9)   
Gene (3)   
   ENSEMBL-UP (3)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (24)   
   InterPro (14)   
   Pfam (8)   
   PROSITE (1)   
   SMART (1)   
All databases (38)   

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ID   W5MDT0_LEPOC            Unreviewed;      2338 AA.
AC   W5MDT0;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Pre-mRNA processing factor 8 {ECO:0000313|Ensembl:ENSLOCP00000006539.1};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000006539.1, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000006539.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AHAT01005800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01005801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7918.ENSLOCP00000006539; -.
DR   Ensembl; ENSLOCT00000006547.1; ENSLOCP00000006539.1; ENSLOCG00000005409.1.
DR   eggNOG; KOG1795; Eukaryota.
DR   GeneTree; ENSGT00390000015210; -.
DR   HOGENOM; CLU_000380_3_0_1; -.
DR   InParanoid; W5MDT0; -.
DR   OMA; ANKWNTS; -.
DR   Proteomes; UP000018468; Linkage group LG22.
DR   Bgee; ENSLOCG00000005409; Expressed in camera-type eye and 13 other cell types or tissues.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005682; C:U5 snRNP; IBA:GO_Central.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   GO; GO:0097157; F:pre-mRNA intronic binding; IBA:GO_Central.
DR   GO; GO:0030619; F:U1 snRNA binding; IBA:GO_Central.
DR   GO; GO:0030620; F:U2 snRNA binding; IBA:GO_Central.
DR   GO; GO:0030623; F:U5 snRNA binding; IBA:GO_Central.
DR   GO; GO:0017070; F:U6 snRNA binding; IBA:GO_Central.
DR   GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IBA:GO_Central.
DR   CDD; cd08056; MPN_PRP8; 1.
DR   CDD; cd13838; RNase_H_like_Prp8_IV; 1.
DR   Gene3D; 1.20.80.40; -; 1.
DR   Gene3D; 3.30.420.230; -; 1.
DR   Gene3D; 3.90.1570.40; -; 1.
DR   Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR   Gene3D; 3.30.43.40; Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain; 1.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR012591; PRO8NT.
DR   InterPro; IPR012592; PROCN.
DR   InterPro; IPR012984; PROCT.
DR   InterPro; IPR027652; PRP8.
DR   InterPro; IPR021983; PRP8_domainIV.
DR   InterPro; IPR043173; Prp8_domainIV_fingers.
DR   InterPro; IPR043172; Prp8_domainIV_palm.
DR   InterPro; IPR019581; Prp8_U5-snRNA-bd.
DR   InterPro; IPR042516; Prp8_U5-snRNA-bd_sf.
DR   InterPro; IPR019580; Prp8_U6-snRNA-bd.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR019582; RRM_spliceosomal_PrP8.
DR   PANTHER; PTHR11140; PRE-MRNA SPLICING FACTOR PRP8; 1.
DR   PANTHER; PTHR11140:SF0; PRE-MRNA-PROCESSING-SPLICING FACTOR 8; 1.
DR   Pfam; PF01398; JAB; 1.
DR   Pfam; PF08082; PRO8NT; 1.
DR   Pfam; PF08083; PROCN; 1.
DR   Pfam; PF08084; PROCT; 1.
DR   Pfam; PF12134; PRP8_domainIV; 1.
DR   Pfam; PF10598; RRM_4; 1.
DR   Pfam; PF10597; U5_2-snRNA_bdg; 1.
DR   Pfam; PF10596; U6-snRNA_bdg; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR   PROSITE; PS50249; MPN; 1.
PE   4: Predicted;
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW   mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT   DOMAIN          2106..2237
FT                   /note="MPN"
FT                   /evidence="ECO:0000259|PROSITE:PS50249"
SQ   SEQUENCE   2338 AA;  273870 MW;  ECF727BDE4309836 CRC64;
     TMAAAAFPYR AAPGTIPTPG QVPDYMSEEK LQEKAARKWQ QLQAKRYAEK RKFGFVDAQK
     EDMPPEHVRK IIRDHGDMTN RKFRHDKRVY LGALKYMPHA VLKLLENMPM PWEQIRDVPV
     LYHITGAISF VNEIPWVIEP VYIAQWGAMW IMMRREKRDR RHFKRMRFPP FDDEEPPLDY
     ADNILDVEPL EAIQMELDPE EDASVADWFY EHQPLKDNTK FVNGCTYRRW QFTLPMMSTL
     YRLANQLLTD LVDDNYFYLF DLKAFFTSKA LNMAIPGGPK FEPLVRDINL QDEDWNEFND
     INKIIIRQPI RTEYKIAFPY LYNNLPHHVH LTWYHTPNVV FIKTEDPDLP AFYFDPLINP
     ISHRHSVKSQ EPVLDDDEEF ELPEYVEPFL KDTPLYTDNT ANGIALLWAP RPFNLRSGRT
     RRAIDIPLIK NWYREHCPAG QPVKVRVSYQ KLLKYYVLNA LKHRPPKAQK KRYLFRSFKA
     TKFFQSTKLD WVEVGLQVCR QGYNMLNLLI HRKNLNYLHL DYNFNLKPVK TLTTKERKKS
     RFGNAFHLCR EVLRLSKLVV DSHVQYRLGN VDAFQLADGL QYIFAHVGQL TGMYRYKYKL
     MRQIRMCKDL KHLIYYRFNT GPVGKGPGCG FWAPGWRVWL FFMRGITPLL ERWLGNLLAR
     QFEGRHSKGV AKTVTKQRVE SHFDLELRAA VMHDILDMMP EGIKQNKART ILQHLSESWR
     CWKANIPWKV PGLPTPIENM ILRYVKAKAD WWTNTAHYNR ERIRRGATVD KTVCKKNLGR
     LTRLYLKAEQ ERQHNYLKDG PYITAEEAVA IYTTTVHWLE SRRFSPIPFP PLSYKHDTKL
     LILALERLKE AYSVKSRLNQ SQREELGLIE QAYDNPHEAL SRIKRHLLTQ RAFKEVGIEF
     MDLYSHLVPV YDVEPLEKIT DAYLDQYLWY EADKRRLFPP WIKPADTEPP PLLVYKWCQG
     INNLQDVWET TEGECNVMLE SRYEKMYEKI DLTLLNRLLR LIVDHNIADY MTAKNNVVIN
     YKDMNHTNSY GIIRGLQFAS FIVQYYGLVM DLLVLGLHRA SEMAGPPQMP NDFLSFQDIA
     TESAHPIRLY CRYIDRIHIF FRFSADEARD LIQRYLTEHP DPNNENIVGY NNKKCWPRDA
     RMRLMKHDVN LGRAVFWDIK NRLPRSVTTV QWENSFVSVY SKDNPNLLFN MCGFECRILP
     KCRTSYEEFT HKDGVWNLQN EVTKERTAQC FLRVDDESMQ RFHNRVRQIL MASGSTTFTK
     IVNKWNTALI GLMTYFREAV VNTQELLDLL VKCENKIQTR IKIGLNSKMP SRFPPVVFYT
     PKELGGLGGM LSMGHVLIPQ SDLRWSKQTD VGITHFRSGM SHEEDQLIPN LYRYIQPWES
     EFIDSQRVWA EYALKRQEAI AQNRRLTLED LEDSWDRGIP RINTLFQKDR HTLAYDKGWR
     VRTDFKQYQV LKQNPFWWTH QRHDGKLWNL NNYRTDMIQA LGGVEGILEH TLFKGTYFPT
     WEGLFWEKAS GFEESMKWKK LTNAQRSGLN QIPNRRFTLW WSPTINRANV YVGFQVQLDL
     TGIFMHGKIP TLKISLIQIF RAHLWQKIHE SIVMDLCQVF DQELDALEIE TVQKETIHPR
     KSYKMNSSCA DILLFASYKW NVSRPSLLAD SKDVMDSTTT QKYWIDIQLR WGDYDSHDIE
     RYARAKFLDY TTDNMSIYPS PTGVLIAIDL AYNLHSGYGN WFPGGKPLIQ QAMAKIMKAN
     PALYVLRERI RKGLQLYSSE PTEPYLSSQN YGELFSNQII WFVDDTNVYR VTIHKTFEGN
     LTTKPINGAI FIFNPRTGQL FLKIIHTSVW AGQKRLGQLA KWKTAEEVAA LIRSLPVEEQ
     PKQIIVTRKG MLDPLEVHLL DFPNIVIKGS ELQLPFQACL KVEKFGDLIL KATEPQMVLF
     NLYDDWLKTI SSYTAFSRLI LILRALHVNN DRAKVILKPD KTTITEPHHI WPTLTDEEWI
     KVEVQLKDLI LADYGKKNNV NVASLTQSEI RDIILGMEIS APSQQRQQIA EIEKQTKEQS
     QLTATQTRTV NKHGDEIITS TTSNYETQTF SSKTEWRVRA ISAANLHLRT NHIYVSSDDI
     KETGYTYILP KNVLKKFICI SDLRAQIAGY LYGTSPPDNP QVKEIRCIVM VPQWGTHQTV
     HLPNQLPQHE YLKEMEPLGW IHTQPNESPQ LSPQDVTTHA KVMADNPSWD GEKTIIITCS
     FTPGSCTLTA YKLTPSGYEW GRQNTDKGNN PKGYLPSHYE RVQMLLSDRF LGFFMVPGQV
     SWNYNFMGVR HDPNMKYDLQ LANPKEFYHE VHRPSHFLNF ASLQEGEIYN ADREDMYA
//

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