ID W5MIR2_LEPOC Unreviewed; 492 AA.
AC W5MIR2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase {ECO:0000313|Ensembl:ENSLOCP00000008271.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000008271.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000008271.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
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DR EMBL; AHAT01013614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MIR2; -.
DR STRING; 7918.ENSLOCP00000008271; -.
DR Ensembl; ENSLOCT00000008281.1; ENSLOCP00000008271.1; ENSLOCG00000006836.1.
DR eggNOG; KOG2941; Eukaryota.
DR GeneTree; ENSGT00390000008647; -.
DR HOGENOM; CLU_012079_0_0_1; -.
DR InParanoid; W5MIR2; -.
DR OMA; CKLIIDW; -.
DR Proteomes; UP000018468; Linkage group LG13.
DR Bgee; ENSLOCG00000006836; Expressed in ovary and 13 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000030; F:mannosyltransferase activity; IBA:GO_Central.
DR GO; GO:0006486; P:protein glycosylation; IBA:GO_Central.
DR CDD; cd03816; GT33_ALG1-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR InterPro; IPR026051; ALG1-like.
DR InterPro; IPR001296; Glyco_trans_1.
DR PANTHER; PTHR13036; BETA1,4 MANNOSYLTRANSFERASE; 1.
DR PANTHER; PTHR13036:SF0; CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 4: Predicted;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..492
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004866146"
FT TRANSMEM 29..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 306..452
FT /note="Glycosyl transferase family 1"
FT /evidence="ECO:0000259|Pfam:PF00534"
SQ SEQUENCE 492 AA; 54753 MW; C97E95ECC3334DA9 CRC64;
PRNTIMAGVL VLLVAVGFAC SYCVTRPGSS WAVLPVIVVG CVLLIARRSR ASRARTNRSV
CVLVLGDVGR SPRMQYHCIS LSKHGYRVSF VGYLGTKPHS DVLASEKIKI VPISDLKGLT
VGPRVLQYVT KVVLQSLQLL CVLLKIDTPA HVLLQNPPGL PSIAVTWLLC AVWGSSFIID
WHNYGYTIMS LTHGEKHPIV RIAKWYERCF GRCSDYNLCV TNAMKEDLHR NWDIKATTLY
DKPPMIFKEA SLESKHSLFL KMAKDFPPFK TRAQREGDGA DRTAFTELDP VTGTVTYAVG
RPALLLSSTS WTEDEDFSVL LKALEAEYEG FIKDGATLPS LVCVITGKGP QKQYYKNLIE
GMHFKHVQIC TPWLEAEDYP VLLGSADLGV CLHKSSSGLD LPMKVVDMFG CCLPVCAIRF
QCLHELVKQG ENGLIFQDSQ ELAEQLKMLL ADFPGVQGML GTFRRTLRDC GLQRWDESWE
QTVLPLLTGD VQ
//
