UniProt: W5MJI1

Database: UniProt
Entry: W5MJI1_LEPOC

LinkDB:  W5MJI1_LEPOC 
Original site:  W5MJI1_LEPOC

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Ontology (13)   
   GO (13)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (30)   
   InterPro (18)   
   Pfam (11)   
   SMART (1)   
All databases (51)   

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ID   W5MJI1_LEPOC            Unreviewed;      4316 AA.
AC   W5MJI1;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=Cytoplasmic dynein 2 heavy chain 1 {ECO:0000256|ARBA:ARBA00023902};
GN   Name=DYNC2H1 {ECO:0000313|Ensembl:ENSLOCP00000008540.1};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000008540.1, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000008540.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   EMBL; AHAT01003056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01003057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_015197180.1; XM_015341694.1.
DR   Ensembl; ENSLOCT00000008550.1; ENSLOCP00000008540.1; ENSLOCG00000007034.1.
DR   GeneID; 102694862; -.
DR   KEGG; loc:102694862; -.
DR   CTD; 79659; -.
DR   GeneTree; ENSGT00940000154620; -.
DR   HOGENOM; CLU_000038_7_2_1; -.
DR   OrthoDB; 312195at2759; -.
DR   Proteomes; UP000018468; Linkage group LG3.
DR   Bgee; ENSLOCG00000007034; Expressed in muscle tissue and 9 other cell types or tissues.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.1270.280; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR049400; DYNC2H1_AAA_dom.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR013594; Dynein_heavy_tail.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45703:SF22; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR   PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08385; DHC_N1; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF21264; DYNC2H1_AAA_dom; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SMART; SM00382; AAA; 3.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT   DOMAIN          1686..1832
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          1973..2128
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2285..2433
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   COILED          1034..1107
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3114..3197
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   4316 AA;  491994 MW;  B2814298FA2047C0 CRC64;
     MPLGLEDTRK DFILTTAANY FGFKPSDPVV SSGGESRELN NFLDDGNEFV LCVQKHGTDL
     LISNKVDSGD TEDKVLVFFK LCPDVITEDN LHSNILVSSM IDSPINTLYQ AVRQVFAPVL
     LKDEKWSQNF DPKLQNLLTE LEMGLGSAVR RTDPYYTGKR GLKDDDVLGI MTPCDEFNYW
     AELSRSAVKS NMRDRAAHFN DLFQPLEKDY SCLDNVSLDD AVSLVNATRE TVDDVWRQTE
     HDPYPQTRMQ RLMDVIGSAL GRYVQKKLDS VKLWDDPFLS VKESLQAGIS VCEQWVGACE
     HLTGQLWKRY TPHQWQGEQY YPERLGKLAK RLEEVLTVRT VHEKLLRLLP PGKQQLLSTA
     CAFEPFAGLN ALHYNPYTEQ LWRAAVSQFE RAIAPAEQEI ASKLKACIMD VQDSPQQLLQ
     AFRKYKELIK RPNISKDLIS ERETLLARLL DYTKGLRTDF ENRCHGVPGE KSGPLAGRNL
     PEVVNNIVWV RHLVLKVEDS IKIAGALLSD LSGFRSFVRY SDDLQEQLRI YEQDQFDDWS
     REVQSRLSDP KSGISLQASN RVMELDHTDG KLKIHYSDRL ATLLREVRQL SALGYAVPAK
     IQQASSTAEK FYRQALILKQ VAHFYNTIDQ QMIPSQRPMM LNYALAFEQV IKNPKAHSRD
     SGGKVQITWD NPKELEVYIT KLQTAAERLS TENRKLRKWH VDFMEKVVTL MNVDLLRHQQ
     RWKDGLQELR TGFATLESQG FRLGDMKPWR QHWNHQLYKA LEHQYQVGLE ALNKNLPEIN
     IDLTFKQGRL QFKPPFEEVR AKYFREMKRF ISIPNQFKGV SEPGEELIFS IMIDRNASGF
     ITIFSKAEDL FRRLARVQDK FKEWVVFGQV DIEALVEKHL HTAQDWERNF KALKARGKES
     ERLPSTEKVD CITINCDPVK AVIDDLIQRL FDALLMSLRK SIQAHAQDID SFLTEAMEIL
     STRPESIDEI GEANMKHGEL KAKKPEILPL FQESEDKNRL LRSVAGGGLD TISTLRAKWD
     KFELMMESHQ LMIKEQVEVM KSNAESRIKV YQNELEKFKA RWDQLKPNDD IIEFGDQETL
     QKCVQTIKDK KLEFDELENT RKKILEDCHH FDLEEPEFSL AHEIIKDIEE FVQMWSLYEE
     YHEGLQEKAK EDWISFRSKT FIFEEFLFMW HDRLRKLEEH TTMTVKLQKE IDKYKMVVPV
     LKYVRGEHLS QDHWLDLFRL LGLPRGSTLE KLVFGDLLKV ADSIVEKASE LKDLNSRAQA
     EVTIREALRE LDLWGIGAVF TLTDYMDSQN RSIKLIKDWK DIVNQVGDNR CLLQSLKDSP
     YYRSFEDKVS IWETKLADLD EYLHNLNAIQ RKWVYLEPIF GRGALPKEQA RFRRVDEDFR
     SIMADVQRDS RVTSLNARAG IRNSLINILD QLQRCQKSLN EFLEEKRSAF PRFYFIGDDD
     LLEILGQATN PAVIQTHLKK LFAGICSVDF DEGFQHITAM KSLEGEVVPL KNKIRISNDV
     EVWLSDLSVE MKETLKQLLY ECVSAGRRSG IDPSSFPSQI LCLAEQIQFT EDVENAIKNQ
     NLQQLEVELM DKLENYTNVD TSNEDSGSTY ASVLQLKLKA LILDVIHNIE VVKQLKEAQI
     HNCEAWVWKK QLRFYLKQDK RCYVQMVDAE FHYTYEYQGN APKLVHTPLT DKCYLTLTQA
     MKMGLGGNPY GPAGTGKTES VKALGGLFGR QVLVFNCDEG IDVKSMGRIF VGLVKCGAWG
     CFDEFNRLEE AVLSAVSMQI QAIQNSLKNQ RSTCELLGKE VELDPNSGIF ITLNPAGKGY
     GGRQKLPDNL KQLFRPVAMS RPDNELIAEV ILYSEGFKDG KILGRKLVAI FNLSRELLTP
     QQHYDWGLRA LKTVLRGCGS LLQQQRKNES KEKIKESHIV VQALRLNTMS KLTFADSSRF
     DALVRDVFPG VDFTDVEYEK LTAALQAVFE EAKLEIIPNQ IKKALELDEQ LRQRMGVVIV
     GPSGAGKSTL WRTLRAALGR IGRVVKQYTM NPKAMARQQL LGHIDMDTRE WSDGVLTNSA
     RQVVREAQEV SSWIICDGDI DPEWIESLNS VLDDNRLLTM PSGERIQFGP NVNFVFETHD
     LSCASPATIS RMGMIFLSDE DTDINSLVKS WLKTQTDECR SNLENWIGDY FEKGLDWVLK
     QNDFVVDTSL VGTVLNGLSH LSGVRERGQF VVNLIRGLGG NLNFKSRQEF AKQVLSWARE
     SPPDLRKPLD TFYDPGTGRL AAYQLQKPEN LSAEDFSNPQ KLPVVQTPDM QRGLDYFRQW
     LCSENRQPFI LVGPEGCGKG MLLHYAFSQL RSTQVATVHC SAQTSSRHVL QKLTQTCLVI
     SSNTGRVYRP KDCERLILYL KDINLPKPDK WGTSNLIAFL QQVLTYHGFY DENLEWVGLE
     NIQIVASMSA GGTVGRHALT SRFTSIVRIC TIDYPDREQL QTIYSAYLQP VLHRSLKNHG
     AWGSAGKIHQ LAGSMVQVYE QVRAKFTVDD YSHYLFTPCI LTQWVLSLFR YDLTGEKSRN
     TTDHVLEIIA YEARRLFRDR LVTAKDISTF DNILQSVIRG DWGSDILENM SDAFYVTWGA
     AHEAGSVIAP GQSLPPHGKP LGRLNSTDLR EVIHKGVVLY GRDNRELDIL LFHEVLEYMS
     RVDRVLSYPG GSLLLAGRAG VGRRTATCVV SHMHGATLFT PKISRGYGLK QFKNDLKNVM
     QMAGIEGQQV LLLLEDYQFV HPSFLEMVNS LLSSGEVPGL YTIEELEPLL STLKDQASQD
     GFTGPIFNYF AYRIQQNLHM VLIMDCTNSN FTINCESNPA LYRKCSVQWM EGWSDSSMRK
     IPEMLLSKLS GDDEKNTSKQ GHKKKVSEHA DITKSFLMIH ESCKEYSATP SQYMSFLHIY
     SSIYSSKKME LIKRQSHLQA GVSKLNEAKA LVDELKSKAA DQSTLLRMKQ TEADAALQEI
     TVSMQNASDQ KTEMEKIQYK IAEEVSKIEE RKAKIEDELK EVQPLVDEAK QAVGNIKPES
     LSEIRSLRMP PDVIRDILEG VLRLMGIFDT SWVSMKSFLA KRGVREDIAT FDARNITHEI
     RESVEELLRR NKASFDPKNA KRASAAAAPL AAWVKANVQY SHVLERIQPL EKEQAGLVEN
     LRKTESRKNK LEDQLNSVGQ KVNELKEKFQ SRTTEAAKLE ADVSKAQETI EAAEKLIHQL
     DGEHKRWNAQ VAQITEELDT LPKRAQLAAA FITYLSAAPE DQRKASLQEW MNSSGLQKFD
     MRHFLCSESE QLIWKSQGLP SDDLSMENAL VILQINALKS RSCACPFLID PSSRATEWLR
     THLKESRLEV INQQDSNFIT ALELAVRFGK TLIIQEMDGV EPVLYPLLRR DLIAQGPRYV
     VQIGDKIIDY NEEFRMFLAT RNPNPFIPPD AASIVTEVNF TTTRAGLRGQ LLALTIQHEK
     PDLETQKTKL LQQEEDKKIQ LAKLEESLLE TLATAQGNIL ENKILIESLN KTKASSALIQ
     ESLTESHRLQ VSLDQERDAY LPLAESASKM YFIITDLSKI NNMYRFSLAA FLRLFQRALQ
     SKKESENTEV RITSLKASLK TMVYEYVCRS LFKADQLMFA LHFVKGMHPE LFQENEWDAF
     TGLIVGDTIR KTDTHKSLRE QIPSWIDQDR VGAVALFKNT FPSLYQNLCL DDADLWVTFS
     CSSACEQDFP PSVVKKISPF QQVLTVQAIR PDRLQSAMAF FASQALGMKE LSPPPLNLKR
     MYKETLEIEP VLIIISPGAD PSQELLELAS ETVGKESYHE VAMGQGQADI AIQALKECAR
     NGEWLCLKNL HLVTAWLPLL EKELNALQPK ASFRLWLTAE VHPKFTPILL QSSLKITYEA
     PPGLKKNLMR TYESWSPEQI SKKGLVPRAQ SLFCLAWFHA VCQERRNYIP QGWTKFYEFS
     LSDLRAGFDI IDRLFEGSRD VQWEFVHGLL ENAIYGGRID NLFDLRILRS YLEQFFNCRL
     ITGSQTRSKK LTAFPFQISL PSSCSIIDYR NIVENLPEDD RPSFFGLPAN IERSSQHIIS
     SQVISQLRIL SRSITAGSKF DREIWSNELS PILNLWKKLN QGSSLIHQKV APPSESQASP
     VLSFIILEQF NAIRLVQSIH QSLAALSKVI RGTSLLTSEV QKLATALLNQ ECPQSWQSKW
     EGPEDPMQYL RAVVARALAI QSWVEKAGRQ SLLSDALDLS ELFHPDTFLN ALRQETARLM
     GCSMDSLKFV ASWKSRITEA KLQVKIDGLK LEGCSFDGNR LSENQHDSPS VSPVPPCYMA
     WIPQSASGCY SPEECISLPL YTSAERTRVV TNIDVPCGGN SDQWIQCGAA LFLKQQ
//

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