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Database: UniProt
Entry: W5MP29_LEPOC
LinkDB: W5MP29_LEPOC
Original site: W5MP29_LEPOC 
ID   W5MP29_LEPOC            Unreviewed;      1950 AA.
AC   W5MP29;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   28-MAR-2018, entry version 28.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000010138, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Ensembl:ENSLOCP00000010138, ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000010138}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AHAT01020072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSLOCT00000010150; ENSLOCP00000010138; ENSLOCG00000008347.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000018468; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018468};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    210    230       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    351    378       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    697    721       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    733    754       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    774    795       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    816    849       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    906    929       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1155   1173       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1194   1213       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1225   1251       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1271   1297       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1390   1416       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1478   1496       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1508   1526       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1538   1558       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1595   1623       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1699   1722       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       88    385       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      453    655       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      706    933       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      943   1149       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1153   1426       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1477   1732       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1736   1796       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED      375    420       {ECO:0000256|SAM:Coils}.
FT   COILED      442    463       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1950 AA;  222040 MW;  31FCE2291C5F3220 CRC64;
     KMAQLLVPPG PDSFHLFNQE SLQAIEKRIA EEKGKKPKGE RPDDDENGPK PNSDLEAGRS
     LPFIYGDTPK GMVSEPLEDL DPYYINEKMF CMLIMCTILT NCSFMTLSNP PDWAKNVEYT
     FTGIYTFESL IKILARGFCV GKFTFLRDPW NWLDFSVILM AYVTEFVDLG NVSALRTFRV
     LRALKTISVI PGLKTIVGAL IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLRHKCIKW
     PIDNVSSINT SDNMHFNSAD NSSFIWLDYI KDKNNYYFLP GRRDALLCGN GSDAGQCPEG
     YTCIKGGQNP DYGYTSFDTF SWAFLSLFRL MTQDFWENLY QQTLRAAGKT YMIFFVLVIF
     LGSFYLVNLI LAVVAMAYEE QNQATMEEAE QKEAEFQAML EQLKKQQEGA QAAAAAAAES
     GEYSGGGGLT ETSSEASKLS SKSAKERRNR RKKRRQKDEE EEKGDNEKFH KSESEDSITK
     RRVFGISIDG NRLSYEKRYS SPHQSLLSMR GSLFSPRRNS RASLFSFRGR ARDVGSENDF
     ADDEHSTFED NDSRRGSLFV PRRQERRNSN ISQNSRSSRV LLPANGKMHC TVDCNGVVSL
     VGGPSVPTSP VGLLLPEATT TTETEIKKKR SGSHQASMDY LEDPSIRQRA LSVASILTNT
     MEELEESRQK CPPCWYKFAN TYLIWDCCPQ WLKIKEIVNL VVMDPFVDLA ITICIVLNTL
     FMAMEHYPMT KEFNHVLSVG NLVFTGIFTA EMFFKVIAMD PYYYFQEGWN IFDGFIVSLS
     LMELGLANVE GLSVLRSFRL LRVFKLAKSW PTLNMLIKII GNSVGALGNL TLVLAIIVFI
     FAVVGMQLFG KSYRDCVCKI SEDCTLPRWH MFDFFHSFLI VFRVLCGEWI ETMWDCMEVA
     GQSMCLIVFM MVMVIGNLVV LNLFLALLLS SFSADNLAAT DDDSEMNNLQ IAVGRIHRGV
     DYIKGNLRES VQKLCVRRKK VLDEIKPLED LNNKKEACIS NHTTVELTKE PEYHKDGNGT
     TSGIGSSVGK YVIDESDYMS FIHNPSLTVT VPIAVGESDF ENLNTEDFSS ESDIEGSKEK
     LDQSSSSEGS TVDIRPPGEG EPIEIEPEES FEPEACFTEG CVRKFQFCQV NIEEGYWKQW
     WTLRKTCFRI VEHNWFETFI IFMILLSSGA LAFEDIYIEQ RKTIKTMLEY ADKVFTYIFI
     LEMLLKWVAY GFVKYFTNAW CWLDFLIVDV SLVSLVANAL GYSELTAIKS LRTLRALRPL
     RALSRFEGMR VVVNALIGAI PSIMNVLLVC LIFWLIFSIM GVNLFAGKYY HCVNTTTDER
     FLVNVVNNMS DCLKLGNGSR WKNVKINFDN VGAGYLALLQ VATFKGWMDI MYAAVDSRDL
     EDQPDYEVNL YMYLYFVIFI IFGSFFTLNL FIGVIIDNFN QQKKKVHYFG GQDIFMTEEQ
     KKYYNAMKKL GSKKPQKPIP RPANKFQGCV FDVVTKQAFD ITIMILICLN MVTMMVETDD
     QSKDMENILY WINLVFIVLF TGECVLKLIS LRHYYFTIGW NIFDFVVVIL SIVGMFLADI
     IEKYFVSPTL FRVIRLARIG RILRLIKGAK GIRTLLFALM MSLPALFNIG LLLFLVMFIY
     AIFGMSNFAY VKKEAGIDDM FNFETFGNSM ICLFQITTSA GWDGLLAPIL NSRAPDCDSE
     KDHPGSSVKG DCGNPSVGIF FFVSYIIISF LIVVNMYIAI ILENFSVATE ESAEPLSEDD
     FEMFYEVWEK FDPDATQFME YAKLSDFADA LEPPLRVPKP NKIQLIAMDL PMVSGERIHC
     LDILFAFTKR VLGEGGEMDA LRGQMEERFM ASNPSKVSYE PITTTLRRKQ EDVSAVIIQR
     AFRRYLMRRT VKQASFMYKE QNKVGVHILD KEEMVIDKYN ENSTTEKTDM TPSTASPPSY
     DSVTKPDKDK YEKDKREKED KGKDVREHKK
//
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